Redox Electrochemistry to Interrogate and Control Biomolecular Communication
Summary: Cells often communicate by the secretion, transport, and perception of molecules. Information conveyed by molecules is encoded, transmitted, and decoded by cells within the context of the prevailing microenvironments. Conversely, in electronics, transmission reliability and message validati...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-09-01
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| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004220307379 |
| _version_ | 1819227221380825088 |
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| author | Eric VanArsdale Juliana Pitzer Gregory F. Payne William E. Bentley |
| author_facet | Eric VanArsdale Juliana Pitzer Gregory F. Payne William E. Bentley |
| author_sort | Eric VanArsdale |
| collection | DOAJ |
| description | Summary: Cells often communicate by the secretion, transport, and perception of molecules. Information conveyed by molecules is encoded, transmitted, and decoded by cells within the context of the prevailing microenvironments. Conversely, in electronics, transmission reliability and message validation are predictable, robust, and less context dependent. In turn, many transformative advances have resulted by the formal consideration of information transfer. One way to explore this potential for biological systems is to create bio-device interfaces that facilitate bidirectional information transfer between biology and electronics. Redox reactions enable this linkage because reduction and oxidation mediate communication within biology and can be coupled with electronics. By manipulating redox reactions, one is able to combine the programmable features of electronics with the ability to interrogate and modulate biological function. In this review, we examine methods to electrochemically interrogate the various components of molecular communication using redox chemistry and to electronically control cell communication using redox electrogenetics. |
| first_indexed | 2024-12-23T10:37:56Z |
| format | Article |
| id | doaj.art-90306d5f44564f0bb1b24d3d96216cf1 |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-12-23T10:37:56Z |
| publishDate | 2020-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-90306d5f44564f0bb1b24d3d96216cf12022-12-21T17:50:14ZengElsevieriScience2589-00422020-09-01239101545Redox Electrochemistry to Interrogate and Control Biomolecular CommunicationEric VanArsdale0Juliana Pitzer1Gregory F. Payne2William E. Bentley3Fischell Department of Bioengineering, University of Maryland, 3102 A. James Clark Hall 8278 Paint Branch Drive, College Park, MD 20742, USA; Institute of Bioscience and Biotechnology Research, University of Maryland, 5115 Plant Sciences Building, College Park, MD 20742, USA; Robert E. Fischell Institute for Biomedical Devices, University of Maryland, Room 5102, A. James Clark Hall, College Park, MD 20742, USAFischell Department of Bioengineering, University of Maryland, 3102 A. James Clark Hall 8278 Paint Branch Drive, College Park, MD 20742, USAInstitute of Bioscience and Biotechnology Research, University of Maryland, 5115 Plant Sciences Building, College Park, MD 20742, USA; Robert E. Fischell Institute for Biomedical Devices, University of Maryland, Room 5102, A. James Clark Hall, College Park, MD 20742, USAFischell Department of Bioengineering, University of Maryland, 3102 A. James Clark Hall 8278 Paint Branch Drive, College Park, MD 20742, USA; Institute of Bioscience and Biotechnology Research, University of Maryland, 5115 Plant Sciences Building, College Park, MD 20742, USA; Robert E. Fischell Institute for Biomedical Devices, University of Maryland, Room 5102, A. James Clark Hall, College Park, MD 20742, USA; Corresponding authorSummary: Cells often communicate by the secretion, transport, and perception of molecules. Information conveyed by molecules is encoded, transmitted, and decoded by cells within the context of the prevailing microenvironments. Conversely, in electronics, transmission reliability and message validation are predictable, robust, and less context dependent. In turn, many transformative advances have resulted by the formal consideration of information transfer. One way to explore this potential for biological systems is to create bio-device interfaces that facilitate bidirectional information transfer between biology and electronics. Redox reactions enable this linkage because reduction and oxidation mediate communication within biology and can be coupled with electronics. By manipulating redox reactions, one is able to combine the programmable features of electronics with the ability to interrogate and modulate biological function. In this review, we examine methods to electrochemically interrogate the various components of molecular communication using redox chemistry and to electronically control cell communication using redox electrogenetics.http://www.sciencedirect.com/science/article/pii/S2589004220307379Bio-ElectrochemistryBioelectronicsCell Biology |
| spellingShingle | Eric VanArsdale Juliana Pitzer Gregory F. Payne William E. Bentley Redox Electrochemistry to Interrogate and Control Biomolecular Communication iScience Bio-Electrochemistry Bioelectronics Cell Biology |
| title | Redox Electrochemistry to Interrogate and Control Biomolecular Communication |
| title_full | Redox Electrochemistry to Interrogate and Control Biomolecular Communication |
| title_fullStr | Redox Electrochemistry to Interrogate and Control Biomolecular Communication |
| title_full_unstemmed | Redox Electrochemistry to Interrogate and Control Biomolecular Communication |
| title_short | Redox Electrochemistry to Interrogate and Control Biomolecular Communication |
| title_sort | redox electrochemistry to interrogate and control biomolecular communication |
| topic | Bio-Electrochemistry Bioelectronics Cell Biology |
| url | http://www.sciencedirect.com/science/article/pii/S2589004220307379 |
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