COVID‐19 and sarcopenia-related traits: a bidirectional Mendelian randomization study
BackgroundEmerging evidence suggested that coronavirus disease 2019 (COVID-19) patients were more prone to acute skeletal muscle loss and suffer sequelae, including weakness, arthromyalgia, depression and anxiety. Meanwhile, it was observed that sarcopenia (SP) was associated with susceptibility, ho...
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| Format: | Article |
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Frontiers Media S.A.
2023-05-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1162936/full |
| _version_ | 1797829973248049152 |
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| author | Chao Liu Chao Liu Ningyuan Liu Yi Zeng Yi Zeng Bo Xiao Bo Xiao Pingxiao Wang Pingxiao Wang Chuqiao Zhou Chuqiao Zhou Yu Xia Yu Xia Ziyue Zhao Ziyue Zhao Tao Xiao Tao Xiao Hui Li Hui Li |
| author_facet | Chao Liu Chao Liu Ningyuan Liu Yi Zeng Yi Zeng Bo Xiao Bo Xiao Pingxiao Wang Pingxiao Wang Chuqiao Zhou Chuqiao Zhou Yu Xia Yu Xia Ziyue Zhao Ziyue Zhao Tao Xiao Tao Xiao Hui Li Hui Li |
| author_sort | Chao Liu |
| collection | DOAJ |
| description | BackgroundEmerging evidence suggested that coronavirus disease 2019 (COVID-19) patients were more prone to acute skeletal muscle loss and suffer sequelae, including weakness, arthromyalgia, depression and anxiety. Meanwhile, it was observed that sarcopenia (SP) was associated with susceptibility, hospitalization and severity of COVID-19. However, it is not known whether there is causal relationship between COVID‐19 and SP-related traits. Mendelian randomization (MR) was a valid method for inferring causality.MethodsData was extracted from the COVID‐19 Host Genetic Initiative and the UK Biobank without sample overlapping. The MR analysis was performed with inverse variance weighted, weighted median, MR-Egger, RAPS and CAUSE, MR-APSS. Sensitivity analysis was conducted with MR-Egger intercept test, Cochran’s Q test, MR-PRESSO to eliminate pleiotropy.ResultsThere was insufficient result in the MR-APSS method to support a direct causal relationship after the Bonferroni correction. Most other MR results were also nominally consistent with the MR-APSS result.ConclusionsOur study first explored the causal relationship between COVID-19 and SP-related traits, but the result indicated that they may indirectly interact with each other. We highlighted that older people had better absorb enough nutrition and strengthen exercise to directly cope with SP during the COVID-19 pandemic. |
| first_indexed | 2024-04-09T13:28:44Z |
| format | Article |
| id | doaj.art-90308c13a2fe47f09db9fd55c4ee602f |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-09T13:28:44Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-90308c13a2fe47f09db9fd55c4ee602f2023-05-10T05:15:56ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-05-011410.3389/fendo.2023.11629361162936COVID‐19 and sarcopenia-related traits: a bidirectional Mendelian randomization studyChao Liu0Chao Liu1Ningyuan Liu2Yi Zeng3Yi Zeng4Bo Xiao5Bo Xiao6Pingxiao Wang7Pingxiao Wang8Chuqiao Zhou9Chuqiao Zhou10Yu Xia11Yu Xia12Ziyue Zhao13Ziyue Zhao14Tao Xiao15Tao Xiao16Hui Li17Hui Li18Department of Orthopedics, the Second Xiangya Hospital of Central South University, Changsha, ChinaOrthopedic Biomedical Materials Engineering Laboratory of Hunan Province, Changsha, ChinaDepartment of Orthopedics, the Second Xiangya Hospital of Central South University, Changsha, ChinaDepartment of Orthopedics, the Second Xiangya Hospital of Central South University, Changsha, ChinaOrthopedic Biomedical Materials Engineering Laboratory of Hunan Province, Changsha, ChinaDepartment of Orthopedics, the Second Xiangya Hospital of Central South University, Changsha, ChinaOrthopedic Biomedical Materials Engineering Laboratory of Hunan Province, Changsha, ChinaDepartment of Orthopedics, the Second Xiangya Hospital of Central South University, Changsha, ChinaOrthopedic Biomedical Materials Engineering Laboratory of Hunan Province, Changsha, ChinaDepartment of Orthopedics, the Second Xiangya Hospital of Central South University, Changsha, ChinaOrthopedic Biomedical Materials Engineering Laboratory of Hunan Province, Changsha, ChinaDepartment of Orthopedics, the Second Xiangya Hospital of Central South University, Changsha, ChinaOrthopedic Biomedical Materials Engineering Laboratory of Hunan Province, Changsha, ChinaDepartment of Orthopedics, the Second Xiangya Hospital of Central South University, Changsha, ChinaOrthopedic Biomedical Materials Engineering Laboratory of Hunan Province, Changsha, ChinaDepartment of Orthopedics, the Second Xiangya Hospital of Central South University, Changsha, ChinaOrthopedic Biomedical Materials Engineering Laboratory of Hunan Province, Changsha, ChinaDepartment of Orthopedics, the Second Xiangya Hospital of Central South University, Changsha, ChinaOrthopedic Biomedical Materials Engineering Laboratory of Hunan Province, Changsha, ChinaBackgroundEmerging evidence suggested that coronavirus disease 2019 (COVID-19) patients were more prone to acute skeletal muscle loss and suffer sequelae, including weakness, arthromyalgia, depression and anxiety. Meanwhile, it was observed that sarcopenia (SP) was associated with susceptibility, hospitalization and severity of COVID-19. However, it is not known whether there is causal relationship between COVID‐19 and SP-related traits. Mendelian randomization (MR) was a valid method for inferring causality.MethodsData was extracted from the COVID‐19 Host Genetic Initiative and the UK Biobank without sample overlapping. The MR analysis was performed with inverse variance weighted, weighted median, MR-Egger, RAPS and CAUSE, MR-APSS. Sensitivity analysis was conducted with MR-Egger intercept test, Cochran’s Q test, MR-PRESSO to eliminate pleiotropy.ResultsThere was insufficient result in the MR-APSS method to support a direct causal relationship after the Bonferroni correction. Most other MR results were also nominally consistent with the MR-APSS result.ConclusionsOur study first explored the causal relationship between COVID-19 and SP-related traits, but the result indicated that they may indirectly interact with each other. We highlighted that older people had better absorb enough nutrition and strengthen exercise to directly cope with SP during the COVID-19 pandemic.https://www.frontiersin.org/articles/10.3389/fendo.2023.1162936/fullCOVID-19sarcopeniamendelian randomizationlong COVID-19aging |
| spellingShingle | Chao Liu Chao Liu Ningyuan Liu Yi Zeng Yi Zeng Bo Xiao Bo Xiao Pingxiao Wang Pingxiao Wang Chuqiao Zhou Chuqiao Zhou Yu Xia Yu Xia Ziyue Zhao Ziyue Zhao Tao Xiao Tao Xiao Hui Li Hui Li COVID‐19 and sarcopenia-related traits: a bidirectional Mendelian randomization study Frontiers in Endocrinology COVID-19 sarcopenia mendelian randomization long COVID-19 aging |
| title | COVID‐19 and sarcopenia-related traits: a bidirectional Mendelian randomization study |
| title_full | COVID‐19 and sarcopenia-related traits: a bidirectional Mendelian randomization study |
| title_fullStr | COVID‐19 and sarcopenia-related traits: a bidirectional Mendelian randomization study |
| title_full_unstemmed | COVID‐19 and sarcopenia-related traits: a bidirectional Mendelian randomization study |
| title_short | COVID‐19 and sarcopenia-related traits: a bidirectional Mendelian randomization study |
| title_sort | covid 19 and sarcopenia related traits a bidirectional mendelian randomization study |
| topic | COVID-19 sarcopenia mendelian randomization long COVID-19 aging |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1162936/full |
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