Body size throughout the life-course and incident benign prostatic hyperplasia-related outcomes and nocturia
Abstract Background Existing evidence suggests that there is an association between body size and prevalent Benign Prostatic Hyperplasia (BPH)-related outcomes and nocturia. However, there is limited evidence on the association between body size throughout the life-course and incident BPH-related ou...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-03-01
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| Series: | BMC Urology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12894-021-00816-5 |
| _version_ | 1830089027874717696 |
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| author | Saira Khan K. Y. Wolin R. Pakpahan R. L. Grubb G. A. Colditz L. Ragard J. Mabie B. N. Breyer G. L. Andriole S. Sutcliffe |
| author_facet | Saira Khan K. Y. Wolin R. Pakpahan R. L. Grubb G. A. Colditz L. Ragard J. Mabie B. N. Breyer G. L. Andriole S. Sutcliffe |
| author_sort | Saira Khan |
| collection | DOAJ |
| description | Abstract Background Existing evidence suggests that there is an association between body size and prevalent Benign Prostatic Hyperplasia (BPH)-related outcomes and nocturia. However, there is limited evidence on the association between body size throughout the life-course and incident BPH-related outcomes. Methods Our study population consisted of men without histories of prostate cancer, BPH-related outcomes, or nocturia in the intervention arm of the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO) (n = 4710). Associations for body size in early- (age 20), mid- (age 50) and late-life (age ≥ 55, mean age 60.7 years) and weight change with incident BPH-related outcomes (including self-reported nocturia and physician diagnosis of BPH, digital rectal examination-estimated prostate volume ≥ 30 cc, and prostate-specific antigen [PSA] concentration > 1.4 ng/mL) were examined using Poisson regression with robust variance estimation. Results Men who were obese in late-life were 25% more likely to report nocturia (Relative Risk (RR): 1.25, 95% Confidence Interval (CI): 1.11–1.40; p-trendfor continuous BMI < 0.0001) and men who were either overweight or obese in late-life were more likely to report a prostate volume ≥ 30 cc (RRoverweight: 1.13, 95% CI 1.07–1.21; RRobese: 1.10, 95% CI 1.02–1.19; p-trendfor continuous BMI = 0.017) as compared to normal weight men. Obesity at ages 20 and 50 was similarly associated with both nocturia and prostate volume ≥ 30 cc. Considering trajectories of body size, men who were normal weight at age 20 and became overweight or obese by later-life had increased risks of nocturia (RRnormal to overweight: 1.09, 95% CI 0.98–1.22; RRnormal to obese: 1.28, 95% CI 1.10–1.47) and a prostate volume ≥ 30 cc (RRnormal to overweight: 1.12, 95% CI 1.05–1.20). Too few men were obese early in life to examine the independent effect of early-life body size. Later-life body size modified the association between physical activity and nocturia. Conclusions We found that later-life body size, independent of early-life body size, was associated with adverse BPH outcomes, suggesting that interventions to reduce body size even late in life can potentially reduce the burden of BPH-related outcomes and nocturia. |
| first_indexed | 2024-12-16T16:37:29Z |
| format | Article |
| id | doaj.art-90311d12af694ab79ff35b9802c6496e |
| institution | Directory Open Access Journal |
| issn | 1471-2490 |
| language | English |
| last_indexed | 2024-12-16T16:37:29Z |
| publishDate | 2021-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Urology |
| spelling | doaj.art-90311d12af694ab79ff35b9802c6496e2022-12-21T22:24:26ZengBMCBMC Urology1471-24902021-03-0121111310.1186/s12894-021-00816-5Body size throughout the life-course and incident benign prostatic hyperplasia-related outcomes and nocturiaSaira Khan0K. Y. Wolin1R. Pakpahan2R. L. Grubb3G. A. Colditz4L. Ragard5J. Mabie6B. N. Breyer7G. L. Andriole8S. Sutcliffe9Epidemiology Program, College of Health Sciences, University of DelawareCoeus HealthDivision of Public Health Sciences, Department of Surgery, Washington University in St. Louis School of MedicineDepartment of Urology, Medical University of South CarolinaDivision of Public Health Sciences, Department of Surgery, Washington University in St. Louis School of MedicineWestatInformation Management Services, Inc.Departments of Urology and Epidemiology and Biostatistics, University of California - San FranciscoDivision of Urologic Surgery, Department of Surgery, Washington University in St. Louis School of MedicineDivision of Public Health Sciences, Department of Surgery, Washington University in St. Louis School of MedicineAbstract Background Existing evidence suggests that there is an association between body size and prevalent Benign Prostatic Hyperplasia (BPH)-related outcomes and nocturia. However, there is limited evidence on the association between body size throughout the life-course and incident BPH-related outcomes. Methods Our study population consisted of men without histories of prostate cancer, BPH-related outcomes, or nocturia in the intervention arm of the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO) (n = 4710). Associations for body size in early- (age 20), mid- (age 50) and late-life (age ≥ 55, mean age 60.7 years) and weight change with incident BPH-related outcomes (including self-reported nocturia and physician diagnosis of BPH, digital rectal examination-estimated prostate volume ≥ 30 cc, and prostate-specific antigen [PSA] concentration > 1.4 ng/mL) were examined using Poisson regression with robust variance estimation. Results Men who were obese in late-life were 25% more likely to report nocturia (Relative Risk (RR): 1.25, 95% Confidence Interval (CI): 1.11–1.40; p-trendfor continuous BMI < 0.0001) and men who were either overweight or obese in late-life were more likely to report a prostate volume ≥ 30 cc (RRoverweight: 1.13, 95% CI 1.07–1.21; RRobese: 1.10, 95% CI 1.02–1.19; p-trendfor continuous BMI = 0.017) as compared to normal weight men. Obesity at ages 20 and 50 was similarly associated with both nocturia and prostate volume ≥ 30 cc. Considering trajectories of body size, men who were normal weight at age 20 and became overweight or obese by later-life had increased risks of nocturia (RRnormal to overweight: 1.09, 95% CI 0.98–1.22; RRnormal to obese: 1.28, 95% CI 1.10–1.47) and a prostate volume ≥ 30 cc (RRnormal to overweight: 1.12, 95% CI 1.05–1.20). Too few men were obese early in life to examine the independent effect of early-life body size. Later-life body size modified the association between physical activity and nocturia. Conclusions We found that later-life body size, independent of early-life body size, was associated with adverse BPH outcomes, suggesting that interventions to reduce body size even late in life can potentially reduce the burden of BPH-related outcomes and nocturia.https://doi.org/10.1186/s12894-021-00816-5Benign Prostatic Hyperplasia (BPH)Body sizeObesityNocturiaProstate volumePLCO |
| spellingShingle | Saira Khan K. Y. Wolin R. Pakpahan R. L. Grubb G. A. Colditz L. Ragard J. Mabie B. N. Breyer G. L. Andriole S. Sutcliffe Body size throughout the life-course and incident benign prostatic hyperplasia-related outcomes and nocturia BMC Urology Benign Prostatic Hyperplasia (BPH) Body size Obesity Nocturia Prostate volume PLCO |
| title | Body size throughout the life-course and incident benign prostatic hyperplasia-related outcomes and nocturia |
| title_full | Body size throughout the life-course and incident benign prostatic hyperplasia-related outcomes and nocturia |
| title_fullStr | Body size throughout the life-course and incident benign prostatic hyperplasia-related outcomes and nocturia |
| title_full_unstemmed | Body size throughout the life-course and incident benign prostatic hyperplasia-related outcomes and nocturia |
| title_short | Body size throughout the life-course and incident benign prostatic hyperplasia-related outcomes and nocturia |
| title_sort | body size throughout the life course and incident benign prostatic hyperplasia related outcomes and nocturia |
| topic | Benign Prostatic Hyperplasia (BPH) Body size Obesity Nocturia Prostate volume PLCO |
| url | https://doi.org/10.1186/s12894-021-00816-5 |
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