The Synapse as a Central Target for Neurodevelopmental Susceptibility to Pesticides
The developmental period of the nervous system is carefully orchestrated and highly vulnerable to alterations. One crucial factor of a properly-functioning nervous system is the synapse, as synaptic signaling is critical for the formation and maturation of neural circuits. Studies show that genetic...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2016-08-01
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| Series: | Toxics |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2305-6304/4/3/18 |
| _version_ | 1818288687131131904 |
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| author | Aimee Vester W. Michael Caudle |
| author_facet | Aimee Vester W. Michael Caudle |
| author_sort | Aimee Vester |
| collection | DOAJ |
| description | The developmental period of the nervous system is carefully orchestrated and highly vulnerable to alterations. One crucial factor of a properly-functioning nervous system is the synapse, as synaptic signaling is critical for the formation and maturation of neural circuits. Studies show that genetic and environmental impacts can affect diverse components of synaptic function. Importantly, synaptic dysfunction is known to be associated with neurologic and psychiatric disorders, as well as more subtle cognitive, psychomotor, and sensory defects. Given the importance of the synapse in numerous domains, we wanted to delineate the effects of pesticide exposure on synaptic function. In this review, we summarize current epidemiologic and molecular studies that demonstrate organochlorine, organophosphate, and pyrethroid pesticide exposures target the developing synapse. We postulate that the synapse plays a central role in synaptic vulnerability to pesticide exposure during neurodevelopment, and the synapse is a worthy candidate for investigating more subtle effects of chronic pesticide exposure in future studies. |
| first_indexed | 2024-12-13T02:00:20Z |
| format | Article |
| id | doaj.art-90318297552b419f9f9761bbdc862cf0 |
| institution | Directory Open Access Journal |
| issn | 2305-6304 |
| language | English |
| last_indexed | 2024-12-13T02:00:20Z |
| publishDate | 2016-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxics |
| spelling | doaj.art-90318297552b419f9f9761bbdc862cf02022-12-22T00:03:17ZengMDPI AGToxics2305-63042016-08-01431810.3390/toxics4030018toxics4030018The Synapse as a Central Target for Neurodevelopmental Susceptibility to PesticidesAimee Vester0W. Michael Caudle1Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USADepartment of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USAThe developmental period of the nervous system is carefully orchestrated and highly vulnerable to alterations. One crucial factor of a properly-functioning nervous system is the synapse, as synaptic signaling is critical for the formation and maturation of neural circuits. Studies show that genetic and environmental impacts can affect diverse components of synaptic function. Importantly, synaptic dysfunction is known to be associated with neurologic and psychiatric disorders, as well as more subtle cognitive, psychomotor, and sensory defects. Given the importance of the synapse in numerous domains, we wanted to delineate the effects of pesticide exposure on synaptic function. In this review, we summarize current epidemiologic and molecular studies that demonstrate organochlorine, organophosphate, and pyrethroid pesticide exposures target the developing synapse. We postulate that the synapse plays a central role in synaptic vulnerability to pesticide exposure during neurodevelopment, and the synapse is a worthy candidate for investigating more subtle effects of chronic pesticide exposure in future studies.http://www.mdpi.com/2305-6304/4/3/18dopamineGABAglutamateneurodevelopmentneurotoxicityorganochlorineorganophosphatepesticidepyrethroidsynapse |
| spellingShingle | Aimee Vester W. Michael Caudle The Synapse as a Central Target for Neurodevelopmental Susceptibility to Pesticides Toxics dopamine GABA glutamate neurodevelopment neurotoxicity organochlorine organophosphate pesticide pyrethroid synapse |
| title | The Synapse as a Central Target for Neurodevelopmental Susceptibility to Pesticides |
| title_full | The Synapse as a Central Target for Neurodevelopmental Susceptibility to Pesticides |
| title_fullStr | The Synapse as a Central Target for Neurodevelopmental Susceptibility to Pesticides |
| title_full_unstemmed | The Synapse as a Central Target for Neurodevelopmental Susceptibility to Pesticides |
| title_short | The Synapse as a Central Target for Neurodevelopmental Susceptibility to Pesticides |
| title_sort | synapse as a central target for neurodevelopmental susceptibility to pesticides |
| topic | dopamine GABA glutamate neurodevelopment neurotoxicity organochlorine organophosphate pesticide pyrethroid synapse |
| url | http://www.mdpi.com/2305-6304/4/3/18 |
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