Aerobic exercise training in heart failure: impact on sympathetic hyperactivity and cardiac and skeletal muscle function
Heart failure is a common endpoint for many forms of cardiovascular disease and a significant cause of morbidity and mortality. Chronic neurohumoral excitation (i.e., sympathetic hyperactivity) has been considered to be a hallmark of heart failure and is associated with a poor prognosis, cardiac dys...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Associação Brasileira de Divulgação Científica
2011-09-01
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| Series: | Brazilian Journal of Medical and Biological Research |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000900002 |
| _version_ | 1818648037268914176 |
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| author | P.C. Brum A.V.N. Bacurau A. Medeiros J.C.B. Ferreira A.S. Vanzelli C.E. Negrão |
| author_facet | P.C. Brum A.V.N. Bacurau A. Medeiros J.C.B. Ferreira A.S. Vanzelli C.E. Negrão |
| author_sort | P.C. Brum |
| collection | DOAJ |
| description | Heart failure is a common endpoint for many forms of cardiovascular disease and a significant cause of morbidity and mortality. Chronic neurohumoral excitation (i.e., sympathetic hyperactivity) has been considered to be a hallmark of heart failure and is associated with a poor prognosis, cardiac dysfunction and remodeling, and skeletal myopathy. Aerobic exercise training is efficient in counteracting sympathetic hyperactivity and its toxic effects on cardiac and skeletal muscles. In this review, we describe the effects of aerobic exercise training on sympathetic hyperactivity, skeletal myopathy, as well as cardiac function and remodeling in human and animal heart failure. We also discuss the mechanisms underlying the effects of aerobic exercise training. |
| first_indexed | 2024-12-17T01:12:03Z |
| format | Article |
| id | doaj.art-9031962da54b4f07aef293b57fd424c3 |
| institution | Directory Open Access Journal |
| issn | 0100-879X 1414-431X |
| language | English |
| last_indexed | 2024-12-17T01:12:03Z |
| publishDate | 2011-09-01 |
| publisher | Associação Brasileira de Divulgação Científica |
| record_format | Article |
| series | Brazilian Journal of Medical and Biological Research |
| spelling | doaj.art-9031962da54b4f07aef293b57fd424c32022-12-21T22:09:07ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research0100-879X1414-431X2011-09-01449827835Aerobic exercise training in heart failure: impact on sympathetic hyperactivity and cardiac and skeletal muscle functionP.C. BrumA.V.N. BacurauA. MedeirosJ.C.B. FerreiraA.S. VanzelliC.E. NegrãoHeart failure is a common endpoint for many forms of cardiovascular disease and a significant cause of morbidity and mortality. Chronic neurohumoral excitation (i.e., sympathetic hyperactivity) has been considered to be a hallmark of heart failure and is associated with a poor prognosis, cardiac dysfunction and remodeling, and skeletal myopathy. Aerobic exercise training is efficient in counteracting sympathetic hyperactivity and its toxic effects on cardiac and skeletal muscles. In this review, we describe the effects of aerobic exercise training on sympathetic hyperactivity, skeletal myopathy, as well as cardiac function and remodeling in human and animal heart failure. We also discuss the mechanisms underlying the effects of aerobic exercise training.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000900002Heart failureExercise trainingSympathetic hyperactivityVentricular functionCardiac remodelingSkeletal myopathy |
| spellingShingle | P.C. Brum A.V.N. Bacurau A. Medeiros J.C.B. Ferreira A.S. Vanzelli C.E. Negrão Aerobic exercise training in heart failure: impact on sympathetic hyperactivity and cardiac and skeletal muscle function Brazilian Journal of Medical and Biological Research Heart failure Exercise training Sympathetic hyperactivity Ventricular function Cardiac remodeling Skeletal myopathy |
| title | Aerobic exercise training in heart failure: impact on sympathetic hyperactivity and cardiac and skeletal muscle function |
| title_full | Aerobic exercise training in heart failure: impact on sympathetic hyperactivity and cardiac and skeletal muscle function |
| title_fullStr | Aerobic exercise training in heart failure: impact on sympathetic hyperactivity and cardiac and skeletal muscle function |
| title_full_unstemmed | Aerobic exercise training in heart failure: impact on sympathetic hyperactivity and cardiac and skeletal muscle function |
| title_short | Aerobic exercise training in heart failure: impact on sympathetic hyperactivity and cardiac and skeletal muscle function |
| title_sort | aerobic exercise training in heart failure impact on sympathetic hyperactivity and cardiac and skeletal muscle function |
| topic | Heart failure Exercise training Sympathetic hyperactivity Ventricular function Cardiac remodeling Skeletal myopathy |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000900002 |
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