<a name="home"></a>Effect of topical dorzolamide on rabbit central corneal thickness
Our objective was to study the effect of dorzolamide on corneal hydration in an 18-week controlled experiment using ultrasonic pachymetry. Twenty-eight male rabbits were divided randomly into four groups. The 7 rabbits in each group received eye drops containing either 2% (w/v) dorzolamide or placeb...
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| Format: | Article |
| Language: | English |
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Associação Brasileira de Divulgação Científica
2006-02-01
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| Series: | Brazilian Journal of Medical and Biological Research |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000200015&lng=en&tlng=en |
| _version_ | 1818174761794011136 |
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| author | G.C. Almeida Jr. S.J. Faria e Souza |
| author_facet | G.C. Almeida Jr. S.J. Faria e Souza |
| author_sort | G.C. Almeida Jr. |
| collection | DOAJ |
| description | Our objective was to study the effect of dorzolamide on corneal hydration in an 18-week controlled experiment using ultrasonic pachymetry. Twenty-eight male rabbits were divided randomly into four groups. The 7 rabbits in each group received eye drops containing either 2% (w/v) dorzolamide or placebo in their right eye, or in their left eye. The 2% dorzolamide rabbits were treated every 8 h. Fellow eyes are defined as eyes which did not receive either dorzolamide or placebo. The study was blind for both the person who applied the drug and the one who performed the pachymetry. The effect of treatments is reported on the basis of the percentage of pachymetric variation compared to the measurement made before drug application. There was no significant difference (P = 0.061) in pachymetric variation between dorzolamide (-4.42 ± 11.71%) and placebo (2.48 ± 9.63%). However, there was a significant difference (P = 0.0034) in pachymetric variation between the dorzolamide fellow eyes (-7.56 ± 10.50%) and the placebo (-4.42 ± 11.71%). In conclusion, dorzolamide did not increase the corneal thickness in rabbits. |
| first_indexed | 2024-12-11T19:49:33Z |
| format | Article |
| id | doaj.art-90325bca238c426d9a030b03958ff976 |
| institution | Directory Open Access Journal |
| issn | 1414-431X |
| language | English |
| last_indexed | 2024-12-11T19:49:33Z |
| publishDate | 2006-02-01 |
| publisher | Associação Brasileira de Divulgação Científica |
| record_format | Article |
| series | Brazilian Journal of Medical and Biological Research |
| spelling | doaj.art-90325bca238c426d9a030b03958ff9762022-12-22T00:52:49ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research1414-431X2006-02-0139227728110.1590/S0100-879X2006000200015S0100-879X2006000200015<a name="home"></a>Effect of topical dorzolamide on rabbit central corneal thicknessG.C. Almeida Jr.0S.J. Faria e Souza1Universidade de São PauloUniversidade de São PauloOur objective was to study the effect of dorzolamide on corneal hydration in an 18-week controlled experiment using ultrasonic pachymetry. Twenty-eight male rabbits were divided randomly into four groups. The 7 rabbits in each group received eye drops containing either 2% (w/v) dorzolamide or placebo in their right eye, or in their left eye. The 2% dorzolamide rabbits were treated every 8 h. Fellow eyes are defined as eyes which did not receive either dorzolamide or placebo. The study was blind for both the person who applied the drug and the one who performed the pachymetry. The effect of treatments is reported on the basis of the percentage of pachymetric variation compared to the measurement made before drug application. There was no significant difference (P = 0.061) in pachymetric variation between dorzolamide (-4.42 ± 11.71%) and placebo (2.48 ± 9.63%). However, there was a significant difference (P = 0.0034) in pachymetric variation between the dorzolamide fellow eyes (-7.56 ± 10.50%) and the placebo (-4.42 ± 11.71%). In conclusion, dorzolamide did not increase the corneal thickness in rabbits.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000200015&lng=en&tlng=enDorzolamideCorneal thicknessCarbonic anhydrase inhibitionUltrasonic pachymetry |
| spellingShingle | G.C. Almeida Jr. S.J. Faria e Souza <a name="home"></a>Effect of topical dorzolamide on rabbit central corneal thickness Brazilian Journal of Medical and Biological Research Dorzolamide Corneal thickness Carbonic anhydrase inhibition Ultrasonic pachymetry |
| title | <a name="home"></a>Effect of topical dorzolamide on rabbit central corneal thickness |
| title_full | <a name="home"></a>Effect of topical dorzolamide on rabbit central corneal thickness |
| title_fullStr | <a name="home"></a>Effect of topical dorzolamide on rabbit central corneal thickness |
| title_full_unstemmed | <a name="home"></a>Effect of topical dorzolamide on rabbit central corneal thickness |
| title_short | <a name="home"></a>Effect of topical dorzolamide on rabbit central corneal thickness |
| title_sort | a name home a effect of topical dorzolamide on rabbit central corneal thickness |
| topic | Dorzolamide Corneal thickness Carbonic anhydrase inhibition Ultrasonic pachymetry |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000200015&lng=en&tlng=en |
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