Genetic analysis of potential biomarkers and therapeutic targets in ferroptosis from psoriasis
IntroductionFerroptosis is associated with multiple pathophysiological processes. Inhibition of ferroptosis has received much concern for some diseases. Nonetheless, there is no study comprehensively illustrating functions of ferroptosis-related genes (FRGs) in psoriasis.MethodsIn this study, FRGs t...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1104462/full |
| _version_ | 1797961488857563136 |
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| author | Man-Ning Wu Dong-Mei Zhou Chun-Yan Jiang Wei-Wen Chen Jia-Chi Chen Yue-Min Zou Tao Han Li-Jia-Ming Zhou |
| author_facet | Man-Ning Wu Dong-Mei Zhou Chun-Yan Jiang Wei-Wen Chen Jia-Chi Chen Yue-Min Zou Tao Han Li-Jia-Ming Zhou |
| author_sort | Man-Ning Wu |
| collection | DOAJ |
| description | IntroductionFerroptosis is associated with multiple pathophysiological processes. Inhibition of ferroptosis has received much concern for some diseases. Nonetheless, there is no study comprehensively illustrating functions of ferroptosis-related genes (FRGs) in psoriasis.MethodsIn this study, FRGs together with psoriasis-associated data were obtained in Ferroptosis Database (FerrDb) and gene expression omnibus (GEO) database separately. This work identified altogether 199 psoriasis-associated DE-FRGs, and they were tightly associated with immunity and autophagy modulation. Thereafter, the present study utilized SVM-RFE and LASSO algorithms to identify NR5A2, CISD1, GCLC, PRKAA2, TRIB2, ABCC5, ACSF2, TIMM9, DCAF7, PEBP1, and MDM2 from those 199 DE-FRGs to be marker genes. As revealed by later functional annotation, the marker genes possibly had important effects on psoriasis through being involved in diverse psoriasis pathogenesis-related pathways such as cell cycle, toll-like receptor (TLR), chemokine, and nod-like receptor (NLR) pathways. Moreover, altogether 37 drugs that targeted 11 marker genes were acquired. Besides, based on CIBERSORT analysis, alterations of immune microenvironment in psoriasis cases were possibly associated with PRKAA2, PEBP1, CISD1, and ACSF2.DiscussionTaken together, this work established the diagnostic potency and shed more lights on psoriasis-related mechanism. More investigations are warranted to validate its value in diagnosing psoriasis before it is applied in clinic. |
| first_indexed | 2024-04-11T00:59:01Z |
| format | Article |
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| institution | Directory Open Access Journal |
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| language | English |
| last_indexed | 2024-04-11T00:59:01Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-9032eea36a42445286ddf58d68c39bca2023-01-04T19:33:51ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-01-011310.3389/fimmu.2022.11044621104462Genetic analysis of potential biomarkers and therapeutic targets in ferroptosis from psoriasisMan-Ning WuDong-Mei ZhouChun-Yan JiangWei-Wen ChenJia-Chi ChenYue-Min ZouTao HanLi-Jia-Ming ZhouIntroductionFerroptosis is associated with multiple pathophysiological processes. Inhibition of ferroptosis has received much concern for some diseases. Nonetheless, there is no study comprehensively illustrating functions of ferroptosis-related genes (FRGs) in psoriasis.MethodsIn this study, FRGs together with psoriasis-associated data were obtained in Ferroptosis Database (FerrDb) and gene expression omnibus (GEO) database separately. This work identified altogether 199 psoriasis-associated DE-FRGs, and they were tightly associated with immunity and autophagy modulation. Thereafter, the present study utilized SVM-RFE and LASSO algorithms to identify NR5A2, CISD1, GCLC, PRKAA2, TRIB2, ABCC5, ACSF2, TIMM9, DCAF7, PEBP1, and MDM2 from those 199 DE-FRGs to be marker genes. As revealed by later functional annotation, the marker genes possibly had important effects on psoriasis through being involved in diverse psoriasis pathogenesis-related pathways such as cell cycle, toll-like receptor (TLR), chemokine, and nod-like receptor (NLR) pathways. Moreover, altogether 37 drugs that targeted 11 marker genes were acquired. Besides, based on CIBERSORT analysis, alterations of immune microenvironment in psoriasis cases were possibly associated with PRKAA2, PEBP1, CISD1, and ACSF2.DiscussionTaken together, this work established the diagnostic potency and shed more lights on psoriasis-related mechanism. More investigations are warranted to validate its value in diagnosing psoriasis before it is applied in clinic.https://www.frontiersin.org/articles/10.3389/fimmu.2022.1104462/fullbioinformaticspsoriasisdiagnosticferroptosisimmune microenvironment |
| spellingShingle | Man-Ning Wu Dong-Mei Zhou Chun-Yan Jiang Wei-Wen Chen Jia-Chi Chen Yue-Min Zou Tao Han Li-Jia-Ming Zhou Genetic analysis of potential biomarkers and therapeutic targets in ferroptosis from psoriasis Frontiers in Immunology bioinformatics psoriasis diagnostic ferroptosis immune microenvironment |
| title | Genetic analysis of potential biomarkers and therapeutic targets in ferroptosis from psoriasis |
| title_full | Genetic analysis of potential biomarkers and therapeutic targets in ferroptosis from psoriasis |
| title_fullStr | Genetic analysis of potential biomarkers and therapeutic targets in ferroptosis from psoriasis |
| title_full_unstemmed | Genetic analysis of potential biomarkers and therapeutic targets in ferroptosis from psoriasis |
| title_short | Genetic analysis of potential biomarkers and therapeutic targets in ferroptosis from psoriasis |
| title_sort | genetic analysis of potential biomarkers and therapeutic targets in ferroptosis from psoriasis |
| topic | bioinformatics psoriasis diagnostic ferroptosis immune microenvironment |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1104462/full |
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