[18F]KS1, a novel ascorbate-based ligand images ROS in tumor models of rodents and nonhuman primates

[18F]KS1, a novel ascorbate-based ligand images ROS in tumor models of rodents and nonhuman primates

Over production of reactive oxygen species (ROS) caused by altered redox regulation of signaling pathways is common in many types of cancers. While PET imaging is recognized as the standard tool for cancer imaging, there are no clinically-approved PET radiotracers for ROS-imaging in cancer diagnosis...

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Bibliographic Details
Main Authors: Naresh Damuka, Nagaraju Bashetti, Akiva Mintz, Avinash H. Bansode, Mack Miller, Ivan Krizan, Cristina Furdui, Bhuvanachandra Bhoopal, Krishna Kumar Gollapelli, JV Shanmukha Kumar, Gagan Deep, Greg Dugan, Mark Cline, Kiran Kumar Solingapuram Sai
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Positron emission tomography imaging
Reactive oxygen species
Ascorbate
Biodistribution, Radioligands
Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332222013269

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http://www.sciencedirect.com/science/article/pii/S0753332222013269

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