Impact of paternal age on embryology and pregnancy outcomes in the setting of a euploid single-embryo transfer with ejaculated sperm: retrospective cohort study
Objective: To evaluate the impact of paternal age on embryology and pregnancy outcomes in the setting of a euploid single-embryo transfer. Design: Retrospective cohort study. Setting: Not applicable. Patient(s): Couples undergoing a first in vitro fertilization cycle with fresh ejaculated sperm who...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2020-09-01
|
| Series: | F&S Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666334120300349 |
| _version_ | 1818620140689817600 |
|---|---|
| author | Brent M. Hanson, M.D. Julia G. Kim, M.D., M.P.H. Emily K. Osman, M.D. Ashley W. Tiegs, M.D. Ruth B. Lathi, M.D. Philip J. Cheng, M.D. Richard T. Scott, Jr., M.D., H.C.L.D. Jason M. Franasiak, M.D., H.C.L.D. |
| author_facet | Brent M. Hanson, M.D. Julia G. Kim, M.D., M.P.H. Emily K. Osman, M.D. Ashley W. Tiegs, M.D. Ruth B. Lathi, M.D. Philip J. Cheng, M.D. Richard T. Scott, Jr., M.D., H.C.L.D. Jason M. Franasiak, M.D., H.C.L.D. |
| author_sort | Brent M. Hanson, M.D. |
| collection | DOAJ |
| description | Objective: To evaluate the impact of paternal age on embryology and pregnancy outcomes in the setting of a euploid single-embryo transfer. Design: Retrospective cohort study. Setting: Not applicable. Patient(s): Couples undergoing a first in vitro fertilization cycle with fresh ejaculated sperm who used intracytoplasmic sperm injection for fertilization followed by preimplantation genetic testing for aneuploidy and single-embryo transfer of a euploid embryo between January 2012 and December 2018. Intervention(s): Not applicable. Main Outcome Measure(s): Embryology outcomes assessed were fertilization rate, blastulation rate, and euploid rate. Pregnancy outcomes assessed included positive human chorionic gonadotropin rate, delivery rate, biochemical loss rate, and clinical loss rate. Results: A total of 4,058 patients were assessed. After adjusting for female age, increased paternal age in the setting of fresh ejaculated sperm use was associated with decreased blastulation and decreased euploid rate using 40 years as an age cutoff. Conclusion(s): In this study, advancing paternal age appears to have a detrimental impact on rates of blastocyst formation and euploid status. However, if a euploid embryo is achieved, older paternal age does not appear to affect negatively pregnancy outcomes. |
| first_indexed | 2024-12-16T17:48:39Z |
| format | Article |
| id | doaj.art-90378fc3664a445f88428b922a77daaa |
| institution | Directory Open Access Journal |
| issn | 2666-3341 |
| language | English |
| last_indexed | 2024-12-16T17:48:39Z |
| publishDate | 2020-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | F&S Reports |
| spelling | doaj.art-90378fc3664a445f88428b922a77daaa2022-12-21T22:22:23ZengElsevierF&S Reports2666-33412020-09-011299105Impact of paternal age on embryology and pregnancy outcomes in the setting of a euploid single-embryo transfer with ejaculated sperm: retrospective cohort studyBrent M. Hanson, M.D.0Julia G. Kim, M.D., M.P.H.1Emily K. Osman, M.D.2Ashley W. Tiegs, M.D.3Ruth B. Lathi, M.D.4Philip J. Cheng, M.D.5Richard T. Scott, Jr., M.D., H.C.L.D.6Jason M. Franasiak, M.D., H.C.L.D.7Department of Reproductive Endocrinology & Infertility, IVI-Reproductive Medicine Associates of New Jersey, Basking Ridge, New Jersey; Division of Reproductive Endocrinology & Infertility, Department of Obstetrics & Gynecology, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, Pennsylvania; Reprint requests: Brent M. Hanson, M.D., IVI-Reproductive Medicine Associates of New Jersey, 140 Allen Rd, Basking Ridge, NJ 07920.Department of Reproductive Endocrinology & Infertility, IVI-Reproductive Medicine Associates of New Jersey, Basking Ridge, New Jersey; Division of Reproductive Endocrinology & Infertility, Department of Obstetrics & Gynecology, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PennsylvaniaDepartment of Reproductive Endocrinology & Infertility, IVI-Reproductive Medicine Associates of New Jersey, Basking Ridge, New Jersey; Division of Reproductive Endocrinology & Infertility, Department of Obstetrics & Gynecology, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PennsylvaniaDepartment of Reproductive Endocrinology & Infertility, IVI-Reproductive Medicine Associates of New Jersey, Basking Ridge, New Jersey; Division of Reproductive Endocrinology & Infertility, Department of Obstetrics & Gynecology, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PennsylvaniaDivision of Reproductive Endocrinology & Infertility, Department of Obstetrics & Gynecology, Stanford Fertility & Reproductive Health Center, Sunnyvale, CaliforniaDepartment of Reproductive Endocrinology & Infertility, IVI-Reproductive Medicine Associates of New Jersey, Basking Ridge, New JerseyDepartment of Reproductive Endocrinology & Infertility, IVI-Reproductive Medicine Associates of New Jersey, Basking Ridge, New Jersey; Division of Reproductive Endocrinology & Infertility, Department of Obstetrics & Gynecology, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PennsylvaniaDepartment of Reproductive Endocrinology & Infertility, IVI-Reproductive Medicine Associates of New Jersey, Basking Ridge, New Jersey; Division of Reproductive Endocrinology & Infertility, Department of Obstetrics & Gynecology, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PennsylvaniaObjective: To evaluate the impact of paternal age on embryology and pregnancy outcomes in the setting of a euploid single-embryo transfer. Design: Retrospective cohort study. Setting: Not applicable. Patient(s): Couples undergoing a first in vitro fertilization cycle with fresh ejaculated sperm who used intracytoplasmic sperm injection for fertilization followed by preimplantation genetic testing for aneuploidy and single-embryo transfer of a euploid embryo between January 2012 and December 2018. Intervention(s): Not applicable. Main Outcome Measure(s): Embryology outcomes assessed were fertilization rate, blastulation rate, and euploid rate. Pregnancy outcomes assessed included positive human chorionic gonadotropin rate, delivery rate, biochemical loss rate, and clinical loss rate. Results: A total of 4,058 patients were assessed. After adjusting for female age, increased paternal age in the setting of fresh ejaculated sperm use was associated with decreased blastulation and decreased euploid rate using 40 years as an age cutoff. Conclusion(s): In this study, advancing paternal age appears to have a detrimental impact on rates of blastocyst formation and euploid status. However, if a euploid embryo is achieved, older paternal age does not appear to affect negatively pregnancy outcomes.http://www.sciencedirect.com/science/article/pii/S2666334120300349AndrologyARTIVFmale factorreproductive aging |
| spellingShingle | Brent M. Hanson, M.D. Julia G. Kim, M.D., M.P.H. Emily K. Osman, M.D. Ashley W. Tiegs, M.D. Ruth B. Lathi, M.D. Philip J. Cheng, M.D. Richard T. Scott, Jr., M.D., H.C.L.D. Jason M. Franasiak, M.D., H.C.L.D. Impact of paternal age on embryology and pregnancy outcomes in the setting of a euploid single-embryo transfer with ejaculated sperm: retrospective cohort study F&S Reports Andrology ART IVF male factor reproductive aging |
| title | Impact of paternal age on embryology and pregnancy outcomes in the setting of a euploid single-embryo transfer with ejaculated sperm: retrospective cohort study |
| title_full | Impact of paternal age on embryology and pregnancy outcomes in the setting of a euploid single-embryo transfer with ejaculated sperm: retrospective cohort study |
| title_fullStr | Impact of paternal age on embryology and pregnancy outcomes in the setting of a euploid single-embryo transfer with ejaculated sperm: retrospective cohort study |
| title_full_unstemmed | Impact of paternal age on embryology and pregnancy outcomes in the setting of a euploid single-embryo transfer with ejaculated sperm: retrospective cohort study |
| title_short | Impact of paternal age on embryology and pregnancy outcomes in the setting of a euploid single-embryo transfer with ejaculated sperm: retrospective cohort study |
| title_sort | impact of paternal age on embryology and pregnancy outcomes in the setting of a euploid single embryo transfer with ejaculated sperm retrospective cohort study |
| topic | Andrology ART IVF male factor reproductive aging |
| url | http://www.sciencedirect.com/science/article/pii/S2666334120300349 |
| work_keys_str_mv | AT brentmhansonmd impactofpaternalageonembryologyandpregnancyoutcomesinthesettingofaeuploidsingleembryotransferwithejaculatedspermretrospectivecohortstudy AT juliagkimmdmph impactofpaternalageonembryologyandpregnancyoutcomesinthesettingofaeuploidsingleembryotransferwithejaculatedspermretrospectivecohortstudy AT emilykosmanmd impactofpaternalageonembryologyandpregnancyoutcomesinthesettingofaeuploidsingleembryotransferwithejaculatedspermretrospectivecohortstudy AT ashleywtiegsmd impactofpaternalageonembryologyandpregnancyoutcomesinthesettingofaeuploidsingleembryotransferwithejaculatedspermretrospectivecohortstudy AT ruthblathimd impactofpaternalageonembryologyandpregnancyoutcomesinthesettingofaeuploidsingleembryotransferwithejaculatedspermretrospectivecohortstudy AT philipjchengmd impactofpaternalageonembryologyandpregnancyoutcomesinthesettingofaeuploidsingleembryotransferwithejaculatedspermretrospectivecohortstudy AT richardtscottjrmdhcld impactofpaternalageonembryologyandpregnancyoutcomesinthesettingofaeuploidsingleembryotransferwithejaculatedspermretrospectivecohortstudy AT jasonmfranasiakmdhcld impactofpaternalageonembryologyandpregnancyoutcomesinthesettingofaeuploidsingleembryotransferwithejaculatedspermretrospectivecohortstudy |