Epigenetic loci for blood pressure are associated with hypertensive target organ damage in older African Americans from the genetic epidemiology network of Arteriopathy (GENOA) study

Epigenetic loci for blood pressure are associated with hypertensive target organ damage in older African Americans from the genetic epidemiology network of Arteriopathy (GENOA) study

Abstract Background Hypertension is a major modifiable risk factor for arteriosclerosis that can lead to target organ damage (TOD) of heart, kidneys, and peripheral arteries. A recent epigenome-wide association study for blood pressure (BP) identified 13 CpG sites, but it is not known whether DNA me...

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Bibliographic Details
Main Authors: Minjung Kho, Wei Zhao, Scott M. Ratliff, Farah Ammous, Thomas H. Mosley, Lulu Shang, Sharon L. R. Kardia, Xiang Zhou, Jennifer A. Smith
Format: Article
Language:English
Published: BMC 2020-09-01
Series:BMC Medical Genomics
Subjects:
Target organ damage
DNA methylation
Hypertension
Estimated glomerular filtration rate
Urinary albumin-creatinine ratio
Left ventricular mass
Online Access:http://link.springer.com/article/10.1186/s12920-020-00791-0

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