Heat Shock Proteins: Connectors between Heart and Kidney
Over the development of eukaryotic cells, intrinsic mechanisms have been developed in order to provide the ability to defend against aggressive agents. In this sense, a group of proteins plays a crucial role in controlling the production of several proteins, guaranteeing cell survival. The heat shoc...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-07-01
|
| Series: | Cells |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4409/10/8/1939 |
| _version_ | 1797524317676765184 |
|---|---|
| author | Carolina Victória Cruz Junho Carolina Amaral Bueno Azevedo Regiane Stafim da Cunha Ainhoa Rodriguez de Yurre Emiliano Medei Andréa Emilia Marques Stinghen Marcela Sorelli Carneiro-Ramos |
| author_facet | Carolina Victória Cruz Junho Carolina Amaral Bueno Azevedo Regiane Stafim da Cunha Ainhoa Rodriguez de Yurre Emiliano Medei Andréa Emilia Marques Stinghen Marcela Sorelli Carneiro-Ramos |
| author_sort | Carolina Victória Cruz Junho |
| collection | DOAJ |
| description | Over the development of eukaryotic cells, intrinsic mechanisms have been developed in order to provide the ability to defend against aggressive agents. In this sense, a group of proteins plays a crucial role in controlling the production of several proteins, guaranteeing cell survival. The heat shock proteins (HSPs), are a family of proteins that have been linked to different cellular functions, being activated under conditions of cellular stress, not only imposed by thermal variation but also toxins, radiation, infectious agents, hypoxia, etc. Regarding pathological situations as seen in cardiorenal syndrome (CRS), HSPs have been shown to be important mediators involved in the control of gene transcription and intracellular signaling, in addition to be an important connector with the immune system. CRS is classified as acute or chronic and according to the first organ to suffer the injury, which can be the heart (CRS type 1 and type 2), kidneys (CRS type 3 and 4) or both (CRS type 5). In all types of CRS, the immune system, redox balance, mitochondrial dysfunction, and tissue remodeling have been the subject of numerous studies in the literature in order to elucidate mechanisms and propose new therapeutic strategies. In this sense, HSPs have been targeted by researchers as important connectors between kidney and heart. Thus, the present review has a focus to present the state of the art regarding the role of HSPs in the pathophysiology of cardiac and renal alterations, as well their role in the kidney–heart axis. |
| first_indexed | 2024-03-10T08:55:39Z |
| format | Article |
| id | doaj.art-9038657efb4d46e099cccab074e0c877 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T08:55:39Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-9038657efb4d46e099cccab074e0c8772023-11-22T07:09:28ZengMDPI AGCells2073-44092021-07-01108193910.3390/cells10081939Heat Shock Proteins: Connectors between Heart and KidneyCarolina Victória Cruz Junho0Carolina Amaral Bueno Azevedo1Regiane Stafim da Cunha2Ainhoa Rodriguez de Yurre3Emiliano Medei4Andréa Emilia Marques Stinghen5Marcela Sorelli Carneiro-Ramos6Center of Natural and Human Sciences (CCNH), Laboratory of Cardiovascular Immunology, Federal University of ABC, Santo André 09210-580, BrazilExperimental Nephrology Laboratory, Basic Pathology Department, Universidade Federal do Paraná, Curitiba 81531-980, BrazilExperimental Nephrology Laboratory, Basic Pathology Department, Universidade Federal do Paraná, Curitiba 81531-980, BrazilLaboratory of Cardioimmunology, Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro 21941-902, BrazilLaboratory of Cardioimmunology, Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro 21941-902, BrazilExperimental Nephrology Laboratory, Basic Pathology Department, Universidade Federal do Paraná, Curitiba 81531-980, BrazilCenter of Natural and Human Sciences (CCNH), Laboratory of Cardiovascular Immunology, Federal University of ABC, Santo André 09210-580, BrazilOver the development of eukaryotic cells, intrinsic mechanisms have been developed in order to provide the ability to defend against aggressive agents. In this sense, a group of proteins plays a crucial role in controlling the production of several proteins, guaranteeing cell survival. The heat shock proteins (HSPs), are a family of proteins that have been linked to different cellular functions, being activated under conditions of cellular stress, not only imposed by thermal variation but also toxins, radiation, infectious agents, hypoxia, etc. Regarding pathological situations as seen in cardiorenal syndrome (CRS), HSPs have been shown to be important mediators involved in the control of gene transcription and intracellular signaling, in addition to be an important connector with the immune system. CRS is classified as acute or chronic and according to the first organ to suffer the injury, which can be the heart (CRS type 1 and type 2), kidneys (CRS type 3 and 4) or both (CRS type 5). In all types of CRS, the immune system, redox balance, mitochondrial dysfunction, and tissue remodeling have been the subject of numerous studies in the literature in order to elucidate mechanisms and propose new therapeutic strategies. In this sense, HSPs have been targeted by researchers as important connectors between kidney and heart. Thus, the present review has a focus to present the state of the art regarding the role of HSPs in the pathophysiology of cardiac and renal alterations, as well their role in the kidney–heart axis.https://www.mdpi.com/2073-4409/10/8/1939heat shock proteinsrenal diseasescardiac diseasesimmune systemcardiorenal syndrome |
| spellingShingle | Carolina Victória Cruz Junho Carolina Amaral Bueno Azevedo Regiane Stafim da Cunha Ainhoa Rodriguez de Yurre Emiliano Medei Andréa Emilia Marques Stinghen Marcela Sorelli Carneiro-Ramos Heat Shock Proteins: Connectors between Heart and Kidney Cells heat shock proteins renal diseases cardiac diseases immune system cardiorenal syndrome |
| title | Heat Shock Proteins: Connectors between Heart and Kidney |
| title_full | Heat Shock Proteins: Connectors between Heart and Kidney |
| title_fullStr | Heat Shock Proteins: Connectors between Heart and Kidney |
| title_full_unstemmed | Heat Shock Proteins: Connectors between Heart and Kidney |
| title_short | Heat Shock Proteins: Connectors between Heart and Kidney |
| title_sort | heat shock proteins connectors between heart and kidney |
| topic | heat shock proteins renal diseases cardiac diseases immune system cardiorenal syndrome |
| url | https://www.mdpi.com/2073-4409/10/8/1939 |
| work_keys_str_mv | AT carolinavictoriacruzjunho heatshockproteinsconnectorsbetweenheartandkidney AT carolinaamaralbuenoazevedo heatshockproteinsconnectorsbetweenheartandkidney AT regianestafimdacunha heatshockproteinsconnectorsbetweenheartandkidney AT ainhoarodriguezdeyurre heatshockproteinsconnectorsbetweenheartandkidney AT emilianomedei heatshockproteinsconnectorsbetweenheartandkidney AT andreaemiliamarquesstinghen heatshockproteinsconnectorsbetweenheartandkidney AT marcelasorellicarneiroramos heatshockproteinsconnectorsbetweenheartandkidney |