6-Bromo-<i>N</i>-(2-methyl-2<i>H</i>-benzo[<i>d</i>][1,2,3]triazol-5-yl)quinolin-4-amine
We describe a straightforward synthesis of the title compound, incorporating a relatively rare 2-methyl-2<i>H</i>-1,2,3-triazole heterocylic motif as a potential kinase inhibitor motif. The small molecule crystal structure has been resolved, revealing an interesting packing arrangement a...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2019-10-01
|
| Series: | Molbank |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-8599/2019/4/M1087 |
| _version_ | 1819123736718082048 |
|---|---|
| author | Christopher R. M. Asquith Graham J. Tizzard |
| author_facet | Christopher R. M. Asquith Graham J. Tizzard |
| author_sort | Christopher R. M. Asquith |
| collection | DOAJ |
| description | We describe a straightforward synthesis of the title compound, incorporating a relatively rare 2-methyl-2<i>H</i>-1,2,3-triazole heterocylic motif as a potential kinase inhibitor motif. The small molecule crystal structure has been resolved, revealing an interesting packing arrangement and overall conformation. We also performed routine characterization with <sup>1</sup>H/<sup>13</sup>C-NMR and liquid chromatography (LC) and high-resolution mass spectra (HRMS). |
| first_indexed | 2024-12-22T07:13:06Z |
| format | Article |
| id | doaj.art-90388ed5c4e043eb93aacdd15df54d39 |
| institution | Directory Open Access Journal |
| issn | 1422-8599 |
| language | English |
| last_indexed | 2024-12-22T07:13:06Z |
| publishDate | 2019-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molbank |
| spelling | doaj.art-90388ed5c4e043eb93aacdd15df54d392022-12-21T18:34:28ZengMDPI AGMolbank1422-85992019-10-0120194M108710.3390/M1087M10876-Bromo-<i>N</i>-(2-methyl-2<i>H</i>-benzo[<i>d</i>][1,2,3]triazol-5-yl)quinolin-4-amineChristopher R. M. Asquith0Graham J. Tizzard1Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USAUK National Crystallography Service, School of Chemistry, University of Southampton, Highfield Campus, Southampton SO17 1BJ, UKWe describe a straightforward synthesis of the title compound, incorporating a relatively rare 2-methyl-2<i>H</i>-1,2,3-triazole heterocylic motif as a potential kinase inhibitor motif. The small molecule crystal structure has been resolved, revealing an interesting packing arrangement and overall conformation. We also performed routine characterization with <sup>1</sup>H/<sup>13</sup>C-NMR and liquid chromatography (LC) and high-resolution mass spectra (HRMS).https://www.mdpi.com/1422-8599/2019/4/M10872-methyl-2<i>h</i>-1,2,3-triazole4-anilino-quin(az)olinesconformational flexibilityhinge binderkinase inhibitor design |
| spellingShingle | Christopher R. M. Asquith Graham J. Tizzard 6-Bromo-<i>N</i>-(2-methyl-2<i>H</i>-benzo[<i>d</i>][1,2,3]triazol-5-yl)quinolin-4-amine Molbank 2-methyl-2<i>h</i>-1,2,3-triazole 4-anilino-quin(az)olines conformational flexibility hinge binder kinase inhibitor design |
| title | 6-Bromo-<i>N</i>-(2-methyl-2<i>H</i>-benzo[<i>d</i>][1,2,3]triazol-5-yl)quinolin-4-amine |
| title_full | 6-Bromo-<i>N</i>-(2-methyl-2<i>H</i>-benzo[<i>d</i>][1,2,3]triazol-5-yl)quinolin-4-amine |
| title_fullStr | 6-Bromo-<i>N</i>-(2-methyl-2<i>H</i>-benzo[<i>d</i>][1,2,3]triazol-5-yl)quinolin-4-amine |
| title_full_unstemmed | 6-Bromo-<i>N</i>-(2-methyl-2<i>H</i>-benzo[<i>d</i>][1,2,3]triazol-5-yl)quinolin-4-amine |
| title_short | 6-Bromo-<i>N</i>-(2-methyl-2<i>H</i>-benzo[<i>d</i>][1,2,3]triazol-5-yl)quinolin-4-amine |
| title_sort | 6 bromo i n i 2 methyl 2 i h i benzo i d i 1 2 3 triazol 5 yl quinolin 4 amine |
| topic | 2-methyl-2<i>h</i>-1,2,3-triazole 4-anilino-quin(az)olines conformational flexibility hinge binder kinase inhibitor design |
| url | https://www.mdpi.com/1422-8599/2019/4/M1087 |
| work_keys_str_mv | AT christopherrmasquith 6bromoini2methyl2ihibenzoidi123triazol5ylquinolin4amine AT grahamjtizzard 6bromoini2methyl2ihibenzoidi123triazol5ylquinolin4amine |