The linker pivot in Ci-VSP: the key to unlock catalysis.
In the voltage-sensitive phosphatase Ci-VSP, conformational changes in the transmembrane voltage sensor domain (VSD) are transduced to the intracellular catalytic domain (CD) leading to its dephosphorylation activity against membrane-embedded phosphoinositides. The linker between both domains is pro...
Main Authors: | Kirstin Hobiger, Tillmann Utesch, Maria Andrea Mroginski, Guiscard Seebohm, Thomas Friedrich |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2013-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3726396?pdf=render |
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