MutL sliding clamps coordinate exonuclease-independent Escherichia coli mismatch repair
The mechanics of MMR strand specific excision that begins at a distant ssDNA break are not yet clear. Here the authors have used multiple single molecule imaging techniques to visualize the behavior of MMR components on mismatched DNA substrates and reveal an exonuclease-independent mechanism for E....
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2019-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-13191-5 |
| _version_ | 1818835236206673920 |
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| author | Jiaquan Liu Ryanggeun Lee Brooke M. Britton James A. London Keunsang Yang Jeungphill Hanne Jong-Bong Lee Richard Fishel |
| author_facet | Jiaquan Liu Ryanggeun Lee Brooke M. Britton James A. London Keunsang Yang Jeungphill Hanne Jong-Bong Lee Richard Fishel |
| author_sort | Jiaquan Liu |
| collection | DOAJ |
| description | The mechanics of MMR strand specific excision that begins at a distant ssDNA break are not yet clear. Here the authors have used multiple single molecule imaging techniques to visualize the behavior of MMR components on mismatched DNA substrates and reveal an exonuclease-independent mechanism for E.coli MMR. |
| first_indexed | 2024-12-19T02:47:30Z |
| format | Article |
| id | doaj.art-903ba956ff58487c9fce0df21e9181e3 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T02:47:30Z |
| publishDate | 2019-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-903ba956ff58487c9fce0df21e9181e32022-12-21T20:38:49ZengNature PortfolioNature Communications2041-17232019-11-0110111510.1038/s41467-019-13191-5MutL sliding clamps coordinate exonuclease-independent Escherichia coli mismatch repairJiaquan Liu0Ryanggeun Lee1Brooke M. Britton2James A. London3Keunsang Yang4Jeungphill Hanne5Jong-Bong Lee6Richard Fishel7Department of Cancer Biology and Genetics, The Ohio State University Wexner Medical CenterDepartment of Physics, Pohang University of Science and Technology (POSTECH)Department of Cancer Biology and Genetics, The Ohio State University Wexner Medical CenterDepartment of Cancer Biology and Genetics, The Ohio State University Wexner Medical CenterSchool of Interdisciplinary Bioscience and Bioengineering, POSTECHDepartment of Cancer Biology and Genetics, The Ohio State University Wexner Medical CenterDepartment of Physics, Pohang University of Science and Technology (POSTECH)Department of Cancer Biology and Genetics, The Ohio State University Wexner Medical CenterThe mechanics of MMR strand specific excision that begins at a distant ssDNA break are not yet clear. Here the authors have used multiple single molecule imaging techniques to visualize the behavior of MMR components on mismatched DNA substrates and reveal an exonuclease-independent mechanism for E.coli MMR.https://doi.org/10.1038/s41467-019-13191-5 |
| spellingShingle | Jiaquan Liu Ryanggeun Lee Brooke M. Britton James A. London Keunsang Yang Jeungphill Hanne Jong-Bong Lee Richard Fishel MutL sliding clamps coordinate exonuclease-independent Escherichia coli mismatch repair Nature Communications |
| title | MutL sliding clamps coordinate exonuclease-independent Escherichia coli mismatch repair |
| title_full | MutL sliding clamps coordinate exonuclease-independent Escherichia coli mismatch repair |
| title_fullStr | MutL sliding clamps coordinate exonuclease-independent Escherichia coli mismatch repair |
| title_full_unstemmed | MutL sliding clamps coordinate exonuclease-independent Escherichia coli mismatch repair |
| title_short | MutL sliding clamps coordinate exonuclease-independent Escherichia coli mismatch repair |
| title_sort | mutl sliding clamps coordinate exonuclease independent escherichia coli mismatch repair |
| url | https://doi.org/10.1038/s41467-019-13191-5 |
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