Animal and Clinical Studies Evaluating Blood Glucose Control With Palatinose-Based Alternative Sweeteners
Animal and clinical studies were performed to determine whether Palatinose-based alternative sweeteners with increased sweetness contributed to blood glucose elevations. In the animal study, male Sprague-Dawley rats (6 weeks old) received an oral load of 2 g of glucose or Palatinose-based alternativ...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-04-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fnut.2020.00052/full |
| _version_ | 1818134105386123264 |
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| author | Jaehyi Jang Kyungae Jo Ki-Bae Hong Eun Young Jung |
| author_facet | Jaehyi Jang Kyungae Jo Ki-Bae Hong Eun Young Jung |
| author_sort | Jaehyi Jang |
| collection | DOAJ |
| description | Animal and clinical studies were performed to determine whether Palatinose-based alternative sweeteners with increased sweetness contributed to blood glucose elevations. In the animal study, male Sprague-Dawley rats (6 weeks old) received an oral load of 2 g of glucose or Palatinose-based alternative sweeteners per kilogram of body weight. Thirty minutes after the glucose load, the rat blood glucose levels in the Palatinose-based alternative sweetener groups were significantly lower than those in the glucose groups (p < 0.05). Palatinose-based alternative sweeteners significantly improved glucose tolerance in rats. However, significant differences in the blood glucose levels were not observed among the Palatinose-based alternative sweeteners. In the clinical study, 14 healthy volunteers (21.4 ± 1.3 years) consumed glucose or Palatinose-based alternative sweeteners (50 g). At 60 min, when Palatinose-based alternative sweeteners were ingested, blood glucose was significantly lower compared to when glucose was ingested (Palatinose-L, 123.1 mg/dL; Palatinose-IS, 125.9 mg/dL; Palatinose-FOS. 129.1 mg/dL vs. glucose, 154.8 mg/dL, p < 0.05). The glycaemic index of Palatinose-L, Palatinose-IS and Palatinose-FOS was 43.9, 58.1, and 49.2, respectively. Palatinose-based alternative sweeteners could help maintain health as the postprandial blood glucose levels are constantly maintained owing to slow hydrolysis. |
| first_indexed | 2024-12-11T09:03:20Z |
| format | Article |
| id | doaj.art-903d53cbae23405fae15494c5b893ee3 |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-12-11T09:03:20Z |
| publishDate | 2020-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-903d53cbae23405fae15494c5b893ee32022-12-22T01:13:42ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2020-04-01710.3389/fnut.2020.00052531823Animal and Clinical Studies Evaluating Blood Glucose Control With Palatinose-Based Alternative SweetenersJaehyi Jang0Kyungae Jo1Ki-Bae Hong2Eun Young Jung3Department of Integrated Biomedical and Life Sciences, Graduate School, Korea University, Seoul, South KoreaBK21 Plus, College of Health Science, Korea University, Seoul, South KoreaDepartment of Food and Nutrition, Dongduk Women's University, Seoul, South KoreaDepartment of Home Economic Education, Jeonju University, Jeonju, South KoreaAnimal and clinical studies were performed to determine whether Palatinose-based alternative sweeteners with increased sweetness contributed to blood glucose elevations. In the animal study, male Sprague-Dawley rats (6 weeks old) received an oral load of 2 g of glucose or Palatinose-based alternative sweeteners per kilogram of body weight. Thirty minutes after the glucose load, the rat blood glucose levels in the Palatinose-based alternative sweetener groups were significantly lower than those in the glucose groups (p < 0.05). Palatinose-based alternative sweeteners significantly improved glucose tolerance in rats. However, significant differences in the blood glucose levels were not observed among the Palatinose-based alternative sweeteners. In the clinical study, 14 healthy volunteers (21.4 ± 1.3 years) consumed glucose or Palatinose-based alternative sweeteners (50 g). At 60 min, when Palatinose-based alternative sweeteners were ingested, blood glucose was significantly lower compared to when glucose was ingested (Palatinose-L, 123.1 mg/dL; Palatinose-IS, 125.9 mg/dL; Palatinose-FOS. 129.1 mg/dL vs. glucose, 154.8 mg/dL, p < 0.05). The glycaemic index of Palatinose-L, Palatinose-IS and Palatinose-FOS was 43.9, 58.1, and 49.2, respectively. Palatinose-based alternative sweeteners could help maintain health as the postprandial blood glucose levels are constantly maintained owing to slow hydrolysis.https://www.frontiersin.org/article/10.3389/fnut.2020.00052/fullpalatinoseisomaltulosealternative sweetenerblood glucoseglycaemic index |
| spellingShingle | Jaehyi Jang Kyungae Jo Ki-Bae Hong Eun Young Jung Animal and Clinical Studies Evaluating Blood Glucose Control With Palatinose-Based Alternative Sweeteners Frontiers in Nutrition palatinose isomaltulose alternative sweetener blood glucose glycaemic index |
| title | Animal and Clinical Studies Evaluating Blood Glucose Control With Palatinose-Based Alternative Sweeteners |
| title_full | Animal and Clinical Studies Evaluating Blood Glucose Control With Palatinose-Based Alternative Sweeteners |
| title_fullStr | Animal and Clinical Studies Evaluating Blood Glucose Control With Palatinose-Based Alternative Sweeteners |
| title_full_unstemmed | Animal and Clinical Studies Evaluating Blood Glucose Control With Palatinose-Based Alternative Sweeteners |
| title_short | Animal and Clinical Studies Evaluating Blood Glucose Control With Palatinose-Based Alternative Sweeteners |
| title_sort | animal and clinical studies evaluating blood glucose control with palatinose based alternative sweeteners |
| topic | palatinose isomaltulose alternative sweetener blood glucose glycaemic index |
| url | https://www.frontiersin.org/article/10.3389/fnut.2020.00052/full |
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