Structural and Dynamics Perspectives on the Binding of Substrate and Inhibitors in Mycobacterium tuberculosis DHFR

Structural and Dynamics Perspectives on the Binding of Substrate and Inhibitors in Mycobacterium tuberculosis DHFR

Dihydrofolate reductase (DHFR), an essential enzyme in the folate pathway, is a potential target for new anti-tuberculosis drugs. Fifteen crystal structures of Mycobacterium tuberculosis DHFR complexed with NADPH and various inhibitors are available in the RCSB Protein Data Bank, but none of them is...

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Bibliographic Details
Main Authors:	Pimonluck Sittikornpaiboon, Pisanu Toochinda, Luckhana Lawtrakul
Format:	Article
Language:	English
Published:	MDPI AG 2017-09-01
Series:	Scientia Pharmaceutica
Subjects:	molecular dynamics simulations antifolates protein-ligand interactions
Online Access:	https://www.mdpi.com/2218-0532/85/3/31

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