Levels of HBV RNA in chronic HBV infected patients during first-line nucleos(t)ide analogues therapy
Abstract Background Serum HBV RNA has been considered a potential biomarker in monitoring the prognosis of chronic hepatitis B (CHB). However, Real-life cohort studies on the profile of HBV RNA in chronic HBV infected patients during first-line nucleos(t)ide analogues (NAs) are lacking. We aimed to...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-12-01
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| Series: | Infectious Agents and Cancer |
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| Online Access: | https://doi.org/10.1186/s13027-022-00473-9 |
| _version_ | 1811203979992891392 |
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| author | Bei Jiang Qinghai Dai Yamin Liu Guangxin Yu Yuqiang Mi |
| author_facet | Bei Jiang Qinghai Dai Yamin Liu Guangxin Yu Yuqiang Mi |
| author_sort | Bei Jiang |
| collection | DOAJ |
| description | Abstract Background Serum HBV RNA has been considered a potential biomarker in monitoring the prognosis of chronic hepatitis B (CHB). However, Real-life cohort studies on the profile of HBV RNA in chronic HBV infected patients during first-line nucleos(t)ide analogues (NAs) are lacking. We aimed to investigate HBV RNA dynamic pattern and clinical value chronic HBV infected patients under NA therapy. Methods HBV RNA and clinical assessments were measured in 82 treatment-naïve chronic HBV infected patients. These enrolled patients were categorized into HBeAg-positive chronic HBV infected (n = 53) and HBeAg-negative chronic HBV infected (n = 29). Of these, there were 59, 46, and 30 chronic HBV infected patients completed the follow-up clinical assessments at 12, 24, and 48 weeks of NAs therapy, respectively. Results In treatment-naïve patients, there was a positive correlation between HBV RNA and HBV DNA, HBsAg (r = 0.602 and 0.502. P < 0.05). The median level of HBV DNA was higher than HBV RNA by 1.64 log10 copies/mL. The mean level of serum HBV RNA was 4.62 (IQR: 3.05–5.82) log10 copies/mL at baseline, and the median level of HBV RNA was 2.88 (IQR: 0–4.67), 2.71 (IQR: 0–4.22), and 2.96 (IQR: 0–4.32) log10 copies/mL at week 12, 24, and 48, respectively. HBV RNA showed a positive linear correlation with HBV DNA at 12, 24, and 48 weeks of NA treatment (r = 0.640, 0.715, and 0.656 respectively, P < 0.05). In patients who were treated 48 weeks NAs, 67% had quantifiable HBV RNA while only 37% had quantifiable HBV DNA. Conclusion HBV RNA has signature profiles in different stages of chronic HBV infected patients receiving first-line NAs. During antiviral treatment, HBV RNA can still monitor the virus activity in patients whose serum HBV DNA cannot be detected. |
| first_indexed | 2024-04-12T03:05:04Z |
| format | Article |
| id | doaj.art-903e72921bf841b2927c394c7c0f9265 |
| institution | Directory Open Access Journal |
| issn | 1750-9378 |
| language | English |
| last_indexed | 2024-04-12T03:05:04Z |
| publishDate | 2022-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Infectious Agents and Cancer |
| spelling | doaj.art-903e72921bf841b2927c394c7c0f92652022-12-22T03:50:32ZengBMCInfectious Agents and Cancer1750-93782022-12-011711910.1186/s13027-022-00473-9Levels of HBV RNA in chronic HBV infected patients during first-line nucleos(t)ide analogues therapyBei Jiang0Qinghai Dai1Yamin Liu2Guangxin Yu3Yuqiang Mi4Tianjin Second People’s Hospital, Tianjin Medical UniversityTianjin Second People’s Hospital, Tianjin Medical UniversityTianjin Second People’s Hospital, Tianjin Medical UniversityDepartment of Microbiology and Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science CenterTianjin Second People’s Hospital, Tianjin Medical UniversityAbstract Background Serum HBV RNA has been considered a potential biomarker in monitoring the prognosis of chronic hepatitis B (CHB). However, Real-life cohort studies on the profile of HBV RNA in chronic HBV infected patients during first-line nucleos(t)ide analogues (NAs) are lacking. We aimed to investigate HBV RNA dynamic pattern and clinical value chronic HBV infected patients under NA therapy. Methods HBV RNA and clinical assessments were measured in 82 treatment-naïve chronic HBV infected patients. These enrolled patients were categorized into HBeAg-positive chronic HBV infected (n = 53) and HBeAg-negative chronic HBV infected (n = 29). Of these, there were 59, 46, and 30 chronic HBV infected patients completed the follow-up clinical assessments at 12, 24, and 48 weeks of NAs therapy, respectively. Results In treatment-naïve patients, there was a positive correlation between HBV RNA and HBV DNA, HBsAg (r = 0.602 and 0.502. P < 0.05). The median level of HBV DNA was higher than HBV RNA by 1.64 log10 copies/mL. The mean level of serum HBV RNA was 4.62 (IQR: 3.05–5.82) log10 copies/mL at baseline, and the median level of HBV RNA was 2.88 (IQR: 0–4.67), 2.71 (IQR: 0–4.22), and 2.96 (IQR: 0–4.32) log10 copies/mL at week 12, 24, and 48, respectively. HBV RNA showed a positive linear correlation with HBV DNA at 12, 24, and 48 weeks of NA treatment (r = 0.640, 0.715, and 0.656 respectively, P < 0.05). In patients who were treated 48 weeks NAs, 67% had quantifiable HBV RNA while only 37% had quantifiable HBV DNA. Conclusion HBV RNA has signature profiles in different stages of chronic HBV infected patients receiving first-line NAs. During antiviral treatment, HBV RNA can still monitor the virus activity in patients whose serum HBV DNA cannot be detected.https://doi.org/10.1186/s13027-022-00473-9HBV RNAHepatitis B virusNucleos(t)ide analoguesHBsAgHBV DNA |
| spellingShingle | Bei Jiang Qinghai Dai Yamin Liu Guangxin Yu Yuqiang Mi Levels of HBV RNA in chronic HBV infected patients during first-line nucleos(t)ide analogues therapy Infectious Agents and Cancer HBV RNA Hepatitis B virus Nucleos(t)ide analogues HBsAg HBV DNA |
| title | Levels of HBV RNA in chronic HBV infected patients during first-line nucleos(t)ide analogues therapy |
| title_full | Levels of HBV RNA in chronic HBV infected patients during first-line nucleos(t)ide analogues therapy |
| title_fullStr | Levels of HBV RNA in chronic HBV infected patients during first-line nucleos(t)ide analogues therapy |
| title_full_unstemmed | Levels of HBV RNA in chronic HBV infected patients during first-line nucleos(t)ide analogues therapy |
| title_short | Levels of HBV RNA in chronic HBV infected patients during first-line nucleos(t)ide analogues therapy |
| title_sort | levels of hbv rna in chronic hbv infected patients during first line nucleos t ide analogues therapy |
| topic | HBV RNA Hepatitis B virus Nucleos(t)ide analogues HBsAg HBV DNA |
| url | https://doi.org/10.1186/s13027-022-00473-9 |
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