Sustained Control of Pyruvate Carboxylase by the Essential Second Messenger Cyclic di-AMP in Bacillus subtilis

Sustained Control of Pyruvate Carboxylase by the Essential Second Messenger Cyclic di-AMP in Bacillus subtilis

ABSTRACT In Bacillus subtilis and other Gram-positive bacteria, cyclic di-AMP is an essential second messenger that signals potassium availability by binding to a variety of proteins. In some bacteria, c-di-AMP also binds to the pyruvate carboxylase to inhibit its activity. We have discovered that i...

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Bibliographic Details
Main Authors: Larissa Krüger, Christina Herzberg, Dennis Wicke, Patricia Scholz, Kerstin Schmitt, Asan Turdiev, Vincent T. Lee, Till Ischebeck, Jörg Stülke
Format: Article
Language:English
Published: American Society for Microbiology 2022-02-01
Series:mBio
Subjects:
Bacillus subtilis
cyclic di-AMP
TCA cycle
protein-protein interaction
pyruvate carboxylase
c-di-AMP
Online Access:https://journals.asm.org/doi/10.1128/mbio.03602-21

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