Cell adhesion molecules in the pathogenesis of the schizophrenia
The causes of schizophrenia remain obscure and complex to identify. Alterations in dopaminergic and serotonergic neurotransmission are, to date, the primary pharmacological targets in treatment. Underlying abnormalities in neural networks have been identified as cell adhesion molecules (CAMs) involv...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Pensoft Publishers
2023-10-01
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| Series: | Folia Medica |
| Online Access: | https://foliamedica.bg/article/101356/download/pdf/ |
| _version_ | 1797641763753558016 |
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| author | Antonino Messina Caterina Crescimanno Giuseppe Cuccì Filippo Caraci Maria Salvina Signorelli |
| author_facet | Antonino Messina Caterina Crescimanno Giuseppe Cuccì Filippo Caraci Maria Salvina Signorelli |
| author_sort | Antonino Messina |
| collection | DOAJ |
| description | The causes of schizophrenia remain obscure and complex to identify. Alterations in dopaminergic and serotonergic neurotransmission are, to date, the primary pharmacological targets in treatment. Underlying abnormalities in neural networks have been identified as cell adhesion molecules (CAMs) involved in synaptic remodeling and interplay between neurons-neurons and neurons-glial cells. Among the CAMs, several families have been identified, such as integrins, selectins, cadherins, immunoglobulins, nectins, and the neuroligin-neurexin complex. In this paper, cell adhesion molecules involved in the pathogenesis of schizophrenia will be described. |
| first_indexed | 2024-03-11T13:50:20Z |
| format | Article |
| id | doaj.art-9041ae923d404c1f9ce509a85b9e394e |
| institution | Directory Open Access Journal |
| issn | 1314-2143 |
| language | English |
| last_indexed | 2024-03-11T13:50:20Z |
| publishDate | 2023-10-01 |
| publisher | Pensoft Publishers |
| record_format | Article |
| series | Folia Medica |
| spelling | doaj.art-9041ae923d404c1f9ce509a85b9e394e2023-11-02T09:11:06ZengPensoft PublishersFolia Medica1314-21432023-10-0165570771210.3897/folmed.65.e101356101356Cell adhesion molecules in the pathogenesis of the schizophreniaAntonino Messina0Caterina Crescimanno1Giuseppe Cuccì2Filippo Caraci3Maria Salvina Signorelli4Mental Health Department of CataniaUniversity of Enna KoreMental Health Department of EnnaUniversity of CataniaPsychiatry Unit, University of CataniaThe causes of schizophrenia remain obscure and complex to identify. Alterations in dopaminergic and serotonergic neurotransmission are, to date, the primary pharmacological targets in treatment. Underlying abnormalities in neural networks have been identified as cell adhesion molecules (CAMs) involved in synaptic remodeling and interplay between neurons-neurons and neurons-glial cells. Among the CAMs, several families have been identified, such as integrins, selectins, cadherins, immunoglobulins, nectins, and the neuroligin-neurexin complex. In this paper, cell adhesion molecules involved in the pathogenesis of schizophrenia will be described.https://foliamedica.bg/article/101356/download/pdf/ |
| spellingShingle | Antonino Messina Caterina Crescimanno Giuseppe Cuccì Filippo Caraci Maria Salvina Signorelli Cell adhesion molecules in the pathogenesis of the schizophrenia Folia Medica |
| title | Cell adhesion molecules in the pathogenesis of the schizophrenia |
| title_full | Cell adhesion molecules in the pathogenesis of the schizophrenia |
| title_fullStr | Cell adhesion molecules in the pathogenesis of the schizophrenia |
| title_full_unstemmed | Cell adhesion molecules in the pathogenesis of the schizophrenia |
| title_short | Cell adhesion molecules in the pathogenesis of the schizophrenia |
| title_sort | cell adhesion molecules in the pathogenesis of the schizophrenia |
| url | https://foliamedica.bg/article/101356/download/pdf/ |
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