Diagnostic Value of Salivary miRNA in Head and Neck Squamous Cell Cancer: Systematic Review and Meta-Analysis
Several studies have highlighted the diagnostic potential of salivary microRNA (miRNA) in head and neck squamous cell cancer (HNSCC). The purpose of this meta-analysis was to summarize published studies and evaluate the diagnostic accuracy of salivary miRNA in HNSCC detection. In this meta-analysis,...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/13/7026 |
| _version_ | 1797411441429446656 |
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| author | Jeong-Wook Kang Young-Gyu Eun Young-Chan Lee |
| author_facet | Jeong-Wook Kang Young-Gyu Eun Young-Chan Lee |
| author_sort | Jeong-Wook Kang |
| collection | DOAJ |
| description | Several studies have highlighted the diagnostic potential of salivary microRNA (miRNA) in head and neck squamous cell cancer (HNSCC). The purpose of this meta-analysis was to summarize published studies and evaluate the diagnostic accuracy of salivary miRNA in HNSCC detection. In this meta-analysis, we systematically searched PubMed, EMBASE, and Cochrane Library databases for studies on miRNA and HNSCC diagnosis. Pooled sensitivity, specificity, and diagnostic odds ratio (DOR) with a summary receiver-operating characteristic curve were calculated using a bivariate random-effect meta-analysis model. Furthermore, subgroup analyses were conducted to explore the main sources of heterogeneity. Seventeen studies from ten articles, including 23 miRNA and a total of 759 subjects, were included in this meta-analysis. The pooled sensitivity and specificity of salivary miRNA in the diagnosis of HNSCC were 0.697 (95% CI: 0.644–0.744) and 0.868 (95% CI: 0.811–0.910), respectively. The overall area under the curve was 0.803 with a DOR of 12.915 (95% CI: 9.512–17.534). Salivary miRNAs are a promising non-invasive diagnostic biomarker with moderate accuracy for HNSCC. These results must be verified by large-scale prospective studies. |
| first_indexed | 2024-03-09T04:46:07Z |
| format | Article |
| id | doaj.art-9042471c43334e21b1317883bdae7b8b |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T04:46:07Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-9042471c43334e21b1317883bdae7b8b2023-12-03T13:15:54ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-06-012213702610.3390/ijms22137026Diagnostic Value of Salivary miRNA in Head and Neck Squamous Cell Cancer: Systematic Review and Meta-AnalysisJeong-Wook Kang0Young-Gyu Eun1Young-Chan Lee2Department of Otolaryngology-Head and Neck Surgery, Kyung Hee University School of Medicine, Seoul 05278, KoreaDepartment of Otolaryngology-Head and Neck Surgery, Kyung Hee University School of Medicine, Seoul 05278, KoreaDepartment of Otolaryngology-Head and Neck Surgery, Kyung Hee University School of Medicine, Seoul 05278, KoreaSeveral studies have highlighted the diagnostic potential of salivary microRNA (miRNA) in head and neck squamous cell cancer (HNSCC). The purpose of this meta-analysis was to summarize published studies and evaluate the diagnostic accuracy of salivary miRNA in HNSCC detection. In this meta-analysis, we systematically searched PubMed, EMBASE, and Cochrane Library databases for studies on miRNA and HNSCC diagnosis. Pooled sensitivity, specificity, and diagnostic odds ratio (DOR) with a summary receiver-operating characteristic curve were calculated using a bivariate random-effect meta-analysis model. Furthermore, subgroup analyses were conducted to explore the main sources of heterogeneity. Seventeen studies from ten articles, including 23 miRNA and a total of 759 subjects, were included in this meta-analysis. The pooled sensitivity and specificity of salivary miRNA in the diagnosis of HNSCC were 0.697 (95% CI: 0.644–0.744) and 0.868 (95% CI: 0.811–0.910), respectively. The overall area under the curve was 0.803 with a DOR of 12.915 (95% CI: 9.512–17.534). Salivary miRNAs are a promising non-invasive diagnostic biomarker with moderate accuracy for HNSCC. These results must be verified by large-scale prospective studies.https://www.mdpi.com/1422-0067/22/13/7026miRNAhead and neckcancerbiomarkersalivasystemic review |
| spellingShingle | Jeong-Wook Kang Young-Gyu Eun Young-Chan Lee Diagnostic Value of Salivary miRNA in Head and Neck Squamous Cell Cancer: Systematic Review and Meta-Analysis International Journal of Molecular Sciences miRNA head and neck cancer biomarker saliva systemic review |
| title | Diagnostic Value of Salivary miRNA in Head and Neck Squamous Cell Cancer: Systematic Review and Meta-Analysis |
| title_full | Diagnostic Value of Salivary miRNA in Head and Neck Squamous Cell Cancer: Systematic Review and Meta-Analysis |
| title_fullStr | Diagnostic Value of Salivary miRNA in Head and Neck Squamous Cell Cancer: Systematic Review and Meta-Analysis |
| title_full_unstemmed | Diagnostic Value of Salivary miRNA in Head and Neck Squamous Cell Cancer: Systematic Review and Meta-Analysis |
| title_short | Diagnostic Value of Salivary miRNA in Head and Neck Squamous Cell Cancer: Systematic Review and Meta-Analysis |
| title_sort | diagnostic value of salivary mirna in head and neck squamous cell cancer systematic review and meta analysis |
| topic | miRNA head and neck cancer biomarker saliva systemic review |
| url | https://www.mdpi.com/1422-0067/22/13/7026 |
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