Effects of sinoaortic denervation on hemodynamic perturbations of prolonged paradoxical sleep deprivation and rapid cold stress in rats
Background: Sleep disturbances and aversive cold stress (CS) are cardiovascular risk factors. This study investigates how homeostatic control autonomic baroreflex influences the hemodynamic perturbations evoked by paradoxical sleep deprivation (PSD) and CS.Methods: Conscious adult male rats were ran...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
IMR Press
2022-04-01
|
| Series: | Journal of Integrative Neuroscience |
| Subjects: | |
| Online Access: | https://www.imrpress.com/journal/JIN/21/3/10.31083/j.jin2103075 |
| _version_ | 1817976576548012032 |
|---|---|
| author | Yia-Ping Liu Chen-Cheng Lin Yu-Chieh Lin Shih-Hung Tsai Che-Se Tung |
| author_facet | Yia-Ping Liu Chen-Cheng Lin Yu-Chieh Lin Shih-Hung Tsai Che-Se Tung |
| author_sort | Yia-Ping Liu |
| collection | DOAJ |
| description | Background: Sleep disturbances and aversive cold stress (CS) are cardiovascular risk factors. This study investigates how homeostatic control autonomic baroreflex influences the hemodynamic perturbations evoked by paradoxical sleep deprivation (PSD) and CS.Methods: Conscious adult male rats were randomly divided into four groups (Sham/CON [control], Sham/PSD, sinoaortic denervation[SAD]/CON, and SAD/PSD). Spectral analysis and SAD were employed to evaluate the effects of a 72-hr PSD with 10-min CS onblood pressure variability and heart rate variability (BPV and HRV) at total power (TP) and three frequency power densities, very-low-frequency (VLF), low frequency (LF), and high frequency (HF). Results: Key findings showed: (I) Compared with the control shamsurgery (Sham/CON), in the natural baseline (PreCS) trial, SAD surgery (SAD/CON) causes high systolic blood pressure (SBP), heartrate (HR), increases LFBPV (low-frequency power of BPV), LF/HFHRV (the ratio LF/HF of HRV), and TPBPV (the total power ofBPV), but decreases HFHRV (high-frequency power of HRV) and VLFHRV (very-low-frequency power of HRV) than the Sham/CONdoes. In the CS trial, SAD/CON increases the CS-induced pressor, increases the CS-elicited spectral density, LF/HFHRV, but decreasesHFBPV than the Sham/CON does. (II) Compared with SAD/CON and Sham/PSD (PSD under sham surgery), in both PreCS and CStrials, SAD/PSD (PSD under SAD) causes high SBP and HR than both SAD/CON and Sham/PSD their SBP and HR. In PreCS, SAD-PSD also changes the spectral density, including increasing Sham-PSD’s LFBPV, LF/HFHRV, VLFBPV, and TPBPV but decreasingSham-PSD’s VLFHRV and TPHRV. However, in CS, SAD-PSD changes the CS-elicited spectral density, including increasing Sham-PSD’s VLFBPV, LF/HFHRV, and TPHRV but decreasing Sham-PSD’s HFBPV and LFBPV. Conclusion: The results suggest baroreflexcombined with other reflex pathways, such as inhibitory renorenal reflex, modulates the vascular and cardiorespiratory responses to PSDunder PreCS and subsequent CS trials. |
| first_indexed | 2024-04-13T22:04:09Z |
| format | Article |
| id | doaj.art-90426067543d4feaaa6c047ae0e2a3e9 |
| institution | Directory Open Access Journal |
| issn | 0219-6352 |
| language | English |
| last_indexed | 2024-04-13T22:04:09Z |
| publishDate | 2022-04-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Journal of Integrative Neuroscience |
| spelling | doaj.art-90426067543d4feaaa6c047ae0e2a3e92022-12-22T02:27:59ZengIMR PressJournal of Integrative Neuroscience0219-63522022-04-012137510.31083/j.jin2103075S0219-6352(22)00335-7Effects of sinoaortic denervation on hemodynamic perturbations of prolonged paradoxical sleep deprivation and rapid cold stress in ratsYia-Ping Liu0Chen-Cheng Lin1Yu-Chieh Lin2Shih-Hung Tsai3Che-Se Tung4Department of Psychiatry, Cheng Hsin General Hospital, 11280 Taipei, TaiwanDepartment of Physiology, National Defense Medical Center, 11490 Taipei, TaiwanDivision of Medical Research & Education, Cheng Hsin General Hospital, 11280 Taipei, TaiwanDepartment of Emergency Medicine, Tri-service General Hospital, National Defense Medical Center, 11490 Taipei, TaiwanDepartment of Physiology, National Defense Medical Center, 11490 Taipei, TaiwanBackground: Sleep disturbances and aversive cold stress (CS) are cardiovascular risk factors. This study investigates how homeostatic control autonomic baroreflex influences the hemodynamic perturbations evoked by paradoxical sleep deprivation (PSD) and CS.Methods: Conscious adult male rats were randomly divided into four groups (Sham/CON [control], Sham/PSD, sinoaortic denervation[SAD]/CON, and SAD/PSD). Spectral analysis and SAD were employed to evaluate the effects of a 72-hr PSD with 10-min CS onblood pressure variability and heart rate variability (BPV and HRV) at total power (TP) and three frequency power densities, very-low-frequency (VLF), low frequency (LF), and high frequency (HF). Results: Key findings showed: (I) Compared with the control shamsurgery (Sham/CON), in the natural baseline (PreCS) trial, SAD surgery (SAD/CON) causes high systolic blood pressure (SBP), heartrate (HR), increases LFBPV (low-frequency power of BPV), LF/HFHRV (the ratio LF/HF of HRV), and TPBPV (the total power ofBPV), but decreases HFHRV (high-frequency power of HRV) and VLFHRV (very-low-frequency power of HRV) than the Sham/CONdoes. In the CS trial, SAD/CON increases the CS-induced pressor, increases the CS-elicited spectral density, LF/HFHRV, but decreasesHFBPV than the Sham/CON does. (II) Compared with SAD/CON and Sham/PSD (PSD under sham surgery), in both PreCS and CStrials, SAD/PSD (PSD under SAD) causes high SBP and HR than both SAD/CON and Sham/PSD their SBP and HR. In PreCS, SAD-PSD also changes the spectral density, including increasing Sham-PSD’s LFBPV, LF/HFHRV, VLFBPV, and TPBPV but decreasingSham-PSD’s VLFHRV and TPHRV. However, in CS, SAD-PSD changes the CS-elicited spectral density, including increasing Sham-PSD’s VLFBPV, LF/HFHRV, and TPHRV but decreasing Sham-PSD’s HFBPV and LFBPV. Conclusion: The results suggest baroreflexcombined with other reflex pathways, such as inhibitory renorenal reflex, modulates the vascular and cardiorespiratory responses to PSDunder PreCS and subsequent CS trials.https://www.imrpress.com/journal/JIN/21/3/10.31083/j.jin2103075spectral analysisparadoxical sleep deprivationcold stressblood pressure variabilityheart rate variabilitysinoaortic denervation |
| spellingShingle | Yia-Ping Liu Chen-Cheng Lin Yu-Chieh Lin Shih-Hung Tsai Che-Se Tung Effects of sinoaortic denervation on hemodynamic perturbations of prolonged paradoxical sleep deprivation and rapid cold stress in rats Journal of Integrative Neuroscience spectral analysis paradoxical sleep deprivation cold stress blood pressure variability heart rate variability sinoaortic denervation |
| title | Effects of sinoaortic denervation on hemodynamic perturbations of prolonged paradoxical sleep deprivation and rapid cold stress in rats |
| title_full | Effects of sinoaortic denervation on hemodynamic perturbations of prolonged paradoxical sleep deprivation and rapid cold stress in rats |
| title_fullStr | Effects of sinoaortic denervation on hemodynamic perturbations of prolonged paradoxical sleep deprivation and rapid cold stress in rats |
| title_full_unstemmed | Effects of sinoaortic denervation on hemodynamic perturbations of prolonged paradoxical sleep deprivation and rapid cold stress in rats |
| title_short | Effects of sinoaortic denervation on hemodynamic perturbations of prolonged paradoxical sleep deprivation and rapid cold stress in rats |
| title_sort | effects of sinoaortic denervation on hemodynamic perturbations of prolonged paradoxical sleep deprivation and rapid cold stress in rats |
| topic | spectral analysis paradoxical sleep deprivation cold stress blood pressure variability heart rate variability sinoaortic denervation |
| url | https://www.imrpress.com/journal/JIN/21/3/10.31083/j.jin2103075 |
| work_keys_str_mv | AT yiapingliu effectsofsinoaorticdenervationonhemodynamicperturbationsofprolongedparadoxicalsleepdeprivationandrapidcoldstressinrats AT chenchenglin effectsofsinoaorticdenervationonhemodynamicperturbationsofprolongedparadoxicalsleepdeprivationandrapidcoldstressinrats AT yuchiehlin effectsofsinoaorticdenervationonhemodynamicperturbationsofprolongedparadoxicalsleepdeprivationandrapidcoldstressinrats AT shihhungtsai effectsofsinoaorticdenervationonhemodynamicperturbationsofprolongedparadoxicalsleepdeprivationandrapidcoldstressinrats AT chesetung effectsofsinoaorticdenervationonhemodynamicperturbationsofprolongedparadoxicalsleepdeprivationandrapidcoldstressinrats |