In Vitro/Ex Vivo Models for the Study of Ischemia Reperfusion Injury during Kidney Perfusion
Oxidative stress is a key element of ischemia–reperfusion injury, occurring during kidney preservation and transplantation. Current options for kidney graft preservation prior to transplantation are static cold storage (CS) and hypothermic machine perfusion (HMP), the latter demonstrating clear impr...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-10-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/21/21/8156 |
| _version_ | 1797549184228786176 |
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| author | Sebastien Giraud Raphaël Thuillier Jérome Cau Thierry Hauet |
| author_facet | Sebastien Giraud Raphaël Thuillier Jérome Cau Thierry Hauet |
| author_sort | Sebastien Giraud |
| collection | DOAJ |
| description | Oxidative stress is a key element of ischemia–reperfusion injury, occurring during kidney preservation and transplantation. Current options for kidney graft preservation prior to transplantation are static cold storage (CS) and hypothermic machine perfusion (HMP), the latter demonstrating clear improvement of preservation quality, particularly for marginal donors, such as extended criteria donors (ECDs) and donation after circulatory death (DCDs). Nevertheless, complications still exist, fostering the need to improve kidney preservation. This review highlights the most promising avenues of in kidney perfusion improvement on two critical aspects: ex vivo and in vitro evaluation. |
| first_indexed | 2024-03-10T15:11:05Z |
| format | Article |
| id | doaj.art-9045f146a7b6445b93fbfbdf59847ceb |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T15:11:05Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-9045f146a7b6445b93fbfbdf59847ceb2023-11-20T19:22:01ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-10-012121815610.3390/ijms21218156In Vitro/Ex Vivo Models for the Study of Ischemia Reperfusion Injury during Kidney PerfusionSebastien Giraud0Raphaël Thuillier1Jérome Cau2Thierry Hauet3INSERM U1082 (IRTOMIT), F-86000 Poitiers, FranceINSERM U1082 (IRTOMIT), F-86000 Poitiers, FranceINSERM U1082 (IRTOMIT), F-86000 Poitiers, FranceINSERM U1082 (IRTOMIT), F-86000 Poitiers, FranceOxidative stress is a key element of ischemia–reperfusion injury, occurring during kidney preservation and transplantation. Current options for kidney graft preservation prior to transplantation are static cold storage (CS) and hypothermic machine perfusion (HMP), the latter demonstrating clear improvement of preservation quality, particularly for marginal donors, such as extended criteria donors (ECDs) and donation after circulatory death (DCDs). Nevertheless, complications still exist, fostering the need to improve kidney preservation. This review highlights the most promising avenues of in kidney perfusion improvement on two critical aspects: ex vivo and in vitro evaluation.https://www.mdpi.com/1422-0067/21/21/8156kidneyin vitrooxidative stressperfusionoxygenation |
| spellingShingle | Sebastien Giraud Raphaël Thuillier Jérome Cau Thierry Hauet In Vitro/Ex Vivo Models for the Study of Ischemia Reperfusion Injury during Kidney Perfusion International Journal of Molecular Sciences kidney in vitro oxidative stress perfusion oxygenation |
| title | In Vitro/Ex Vivo Models for the Study of Ischemia Reperfusion Injury during Kidney Perfusion |
| title_full | In Vitro/Ex Vivo Models for the Study of Ischemia Reperfusion Injury during Kidney Perfusion |
| title_fullStr | In Vitro/Ex Vivo Models for the Study of Ischemia Reperfusion Injury during Kidney Perfusion |
| title_full_unstemmed | In Vitro/Ex Vivo Models for the Study of Ischemia Reperfusion Injury during Kidney Perfusion |
| title_short | In Vitro/Ex Vivo Models for the Study of Ischemia Reperfusion Injury during Kidney Perfusion |
| title_sort | in vitro ex vivo models for the study of ischemia reperfusion injury during kidney perfusion |
| topic | kidney in vitro oxidative stress perfusion oxygenation |
| url | https://www.mdpi.com/1422-0067/21/21/8156 |
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