CVAM: CNA Profile Inference of the Spatial Transcriptome Based on the VGAE and HMM

Tumors are often polyclonal due to copy number alteration (CNA) events. Through the CNA profile, we can understand the tumor heterogeneity and consistency. CNA information is usually obtained through DNA sequencing. However, many existing studies have shown a positive correlation between the gene ex...

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Bibliographic Details
Main Authors: Jian Ma, Jingjing Guo, Zhiwei Fan, Weiling Zhao, Xiaobo Zhou
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Biomolecules
Subjects:
Online Access:https://www.mdpi.com/2218-273X/13/5/767