The pan-inhibitor of Aurora kinases danusertib induces apoptosis and autophagy and suppresses epithelial-to-mesenchymal transition in human breast cancer cells

The pan-inhibitor of Aurora kinases danusertib induces apoptosis and autophagy and suppresses epithelial-to-mesenchymal transition in human breast cancer cells

Jin-Ping Li,1,2 Yin-Xue Yang,3 Qi-Lun Liu,1 Zhi-Wei Zhou,2,4 Shu-Ting Pan,2,5 Zhi-Xu He,4 Xueji Zhang,6 Tianxin Yang,7 Si-Yuan Pan,8 Wei Duan,9 Shu-Ming He,10 Xiao-Wu Chen,11 Jia-Xuan Qiu,5 Shu-Feng Zhou2,41Department of Surgical Oncology, General Hospital of Ningxia Medical University, Yinchuan, Ni...

Full description

Bibliographic Details
Main Authors:	Li JP, Yang YX, Liu QL, Zhou ZW, Pan ST, He ZX, Zhang X, Yang T, Pan SY, Duan W, He SM, Chen XW, Qiu JX, Zhou SF
Format:	Article
Language:	English
Published:	Dove Medical Press 2015-02-01
Series:	Drug Design, Development and Therapy
Online Access:	http://www.dovepress.com/the-pan-inhibitor-of-aurora-kinases-danusertib-induces-apoptosis-and-a-peer-reviewed-article-DDDT

Similar Items

Danusertib, a potent pan-Aurora kinase and ABL kinase inhibitor, induces cell cycle arrest and programmed cell death and inhibits epithelial to mesenchymal transition involving the PI3K/Akt/mTOR-mediated signaling pathway in human gastric cancer AGS and NCI-N78 cells
by: Yuan CX, et al.
Published: (2015-03-01)

Schisandrin B inhibits cell growth and induces cellular apoptosis and autophagy in mouse hepatocytes and macrophages: implications for its hepatotoxicity
by: Zhang Y, et al.
Published: (2015-04-01)

Alisertib, an Aurora kinase A inhibitor, induces apoptosis and autophagy but inhibits epithelial to mesenchymal transition in human epithelial ovarian cancer cells
by: Ding YH, et al.
Published: (2015-01-01)

Injectable long-acting systems for Radix Ophiopogonis polysaccharide based on mono-PEGylation and in situ formation of a PLGA depot
by: Shi XL, et al.
Published: (2014-11-01)

Plumbagin induces G2/M arrest, apoptosis, and autophagy via p38 MAPK- and PI3K/Akt/mTOR-mediated pathways in human tongue squamous cell carcinoma cells
by: Pan ST, et al.
Published: (2015-03-01)

Pro-apoptotic and pro-autophagic effects of the Aurora kinase A inhibitor alisertib (MLN8237) on human osteosarcoma U-2 OS and MG-63 cells through the activation of mitochondria-mediated pathway and inhibition of p38 MAPK/PI3K/Akt/mTOR signaling pathway
by: Niu NK, et al.
Published: (2015-03-01)

Enhancement of osseointegration of polyethylene terephthalate artificial ligament by coating of silk fibroin and depositing of hydroxyapatite
by: Jiang J, et al.
Published: (2014-09-01)

Effect of particle size on oral absorption of carvedilol nanosuspensions: in vitro and in vivo evaluation
by: Liu DD, et al.
Published: (2015-10-01)

Medical cannabis ‒ the Canadian perspective 
by: Ko GD, et al.
Published: (2016-09-01)

Proteomic response to 5,6-dimethylxanthenone 4-acetic acid (DMXAA, vadimezan) in human non-small cell lung cancer A549 cells determined by the stable-isotope labeling by amino acids in cell culture (SILAC) approach
by: Pan ST, et al.
Published: (2015-02-01)

MicroRNAs and Exosomal microRNAs May Be Possible Targets to Investigate in Gestational Diabetes Mellitus
by: Yang X, et al.
Published: (2022-02-01)

Bioethics in Correlation with the Principle of Human Dignity
by: Sanita Osipova
Published: (2020-10-01)

Treatment of human pre-B acute lymphoblastic leukemia with the Aurora kinase inhibitor PHA-739358 (Danusertib)
by: Fei Fei, et al.
Published: (2012-06-01)

Schisandra chinensis regulates drug metabolizing enzymes and drug transporters via activation of Nrf2-mediated signaling pathway
by: He JL, et al.
Published: (2014-12-01)

A computational and functional study elicits the ameliorating effect of the Chinese herbal formula Huo Luo Xiao Ling Dan on experimental ischemia-induced myocardial injury in rats via inhibition of apoptosis
by: Han XD, et al.
Published: (2015-02-01)

Emergence of Almost Identical F36:A-:B32 Plasmids Carrying blaNDM-5 and qepA in Escherichia coli from Both Pakistan and Canada
by: Baloch Z, et al.
Published: (2019-12-01)

Patient-reported treatment satisfaction and choice of dosing frequency with biologic treatment for moderate to severe plaque psoriasis
by: Zhang M, et al.
Published: (2015-06-01)

Association analysis of polymorphisms in STARD6 and near ECHDC3 in Alzheimer’s disease patients carrying the APOE ε4 Allele
by: Yin J, et al.
Published: (2019-01-01)

The analyses of risk factors for COPD in the Li ethnic group in Hainan, People’s Republic of China
by: Ding YP, et al.
Published: (2015-11-01)

Plumbagin suppresses epithelial to mesenchymal transition and stemness via inhibiting Nrf2-mediated signaling pathway in human tongue squamous cell carcinoma cells
by: Pan ST, et al.
Published: (2015-10-01)

A toxic organic solvent-free technology for the preparation of PEGylated paclitaxel nanosuspension based on human serum albumin for effective cancer therapy
by: Yin TJ, et al.
Published: (2015-12-01)

Alisertib induces cell cycle arrest and autophagy and suppresses epithelial-to-mesenchymal transition involving PI3K/Akt/mTOR and sirtuin 1-mediated signaling pathways in human pancreatic cancer cells
by: Wang F, et al.
Published: (2015-01-01)

Cervical Ossification of Ligamentum Flavum: Elaborating an Underappreciated but Occasional Contributor to Myeloradiculopathy in Aging Population Based on Synthesis of Individual Participant Data
by: Zhang B, et al.
Published: (2021-05-01)

An integrated study on antimicrobial activity and ecotoxicity of quantum dots and quantum dots coated with the antimicrobial peptide indolicidin
by: Galdiero E, et al.
Published: (2016-08-01)

Aminaphtone in the control of gingival bleeding in children
by: Pereira de Godoy JM, et al.
Published: (2014-09-01)

Nordisk barnelitteratur  ̶  et nytt kunstforskningsspørsmål?
by: Kristin Ørjasæter, et al.
Published: (2013-05-01)

The N6-Methyladenosine (m6A) Methylation Gene YTHDF1 Reveals a Potential Diagnostic Role for Gastric Cancer
by: Liu T, et al.
Published: (2020-11-01)

Comparison of blood gas analysis parameters, biochemical tests and hematological parameters in geriatric patients admitted to the emergency department
by: Ayşegül Bilge, et al.
Published: (2023-04-01)

Incident Management for Explainable and Automated Root Cause Analysis in Cloud Data Centers&nbsp;&nbsp;&nbsp;&nbsp;
by: Arnak Poghosyan, et al.
Published: (2021-11-01)

Optimal management of pulmonary arterial hypertension: prognostic indicators to determine treatment course
by: Baldi F, et al.
Published: (2014-10-01)

Operative management of intracerebral hemorrhage: 3 year experience in multidisciplinary city hospital
by: Iroda Mammadinova, et al.
Published: (2022-10-01)

Design, synthesis, and antitumor evaluation of histone deacetylase inhibitors with L-phenylglycine scaffold
by: Zhang Y, et al.
Published: (2015-10-01)

Use of electrical impedance spectroscopy to detect malignant and potentially malignant oral lesions
by: Murdoch C, et al.
Published: (2014-09-01)

Delivery of DNAzyme targeting aurora kinase A to inhibit the proliferation and migration of human prostate cancer
by: Xing Z, et al.
Published: (2015-09-01)

The inspiratory capacity/total lung capacity ratio as a predictor of survival in an emphysematous phenotype of chronic obstructive pulmonary disease
by: French A, et al.
Published: (2015-07-01)

Profile of netupitant/palonosetron (NEPA) fixed dose combination and its potential in the treatment of chemotherapy-induced nausea and vomiting (CINV)
by: Navari RM
Published: (2014-12-01)

Overexpression of miR-100 inhibits cell proliferation, migration, and chemosensitivity in human glioblastoma through FGFR3
by: Luan YX, et al.
Published: (2015-11-01)

Association of metabotropic glutamate receptor 3 gene polymorphisms with schizophrenia risk: evidence from a meta-analysis
by: Yang X, et al.
Published: (2015-03-01)

Application of the Concept of Indirect Discrimination by Latvian Courts
by: Kristīne Dupate
Published: (2020-10-01)

Clinical utility of exemestane in the treatment of breast cancer 
by: Zucchini G, et al.
Published: (2015-05-01)