Simultaneous Improvement of Dissolution Behavior and Oral Bioavailability of Antifungal Miconazole via Cocrystal and Salt Formation

Simultaneous Improvement of Dissolution Behavior and Oral Bioavailability of Antifungal Miconazole via Cocrystal and Salt Formation

Miconazole shows low oral bioavailability in humans due to poor aqueous solubility, although it has demonstrated various pharmacological activities such as antifungal, anti-tubercular and anti-tumor effects. Cocrystal/salt formation is one of the effective methods for solving this problem. In this s...

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Bibliographic Details
Main Authors: Ksenia V. Drozd, Alex N. Manin, Denis E. Boycov, German L. Perlovich
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Pharmaceutics
Subjects:
antifungal
miconazole
dicarboxylic acids
grinding
slurry
lyophilization
Online Access:https://www.mdpi.com/1999-4923/14/5/1107

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