Clinical Characteristics, Treatment Modalities, and Potential Contributing and Prognostic Factors in Patients with Bone Metastases from Gynecological Cancers: A Systematic Review
The purpose of this study is to review the clinical characteristics, treatment modalities, and potential contributing and prognostic factors of bone metastases from gynecological cancers (GCs). A systematic literature search on PubMed, Scopus, Web of Science Core Collection and Cochrane Central Regi...
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MDPI AG
2021-09-01
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Online Access: | https://www.mdpi.com/2075-4418/11/9/1626 |
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author | Francesca Salamanna Anna Myriam Perrone Deyanira Contartese Veronica Borsari Alessandro Gasbarrini Silvia Terzi Pierandrea De Iaco Milena Fini |
author_facet | Francesca Salamanna Anna Myriam Perrone Deyanira Contartese Veronica Borsari Alessandro Gasbarrini Silvia Terzi Pierandrea De Iaco Milena Fini |
author_sort | Francesca Salamanna |
collection | DOAJ |
description | The purpose of this study is to review the clinical characteristics, treatment modalities, and potential contributing and prognostic factors of bone metastases from gynecological cancers (GCs). A systematic literature search on PubMed, Scopus, Web of Science Core Collection and Cochrane Central Register of Controlled Trials databases was conducted. Thirty-one studies, all retrospective, were included in this review, for a total of 2880 patients with GC bone metastases. Primary tumors leading to bone metastases included endometrial cancer (EC), cervical cancer (CC), ovarian cancer (OC), uterine sarcoma (US) and vulvar cancer (VuC), mainly with an International Federation of Gynecology and Obstetrics (FIGO) Stage of III and IV. The main bone metastatic lesion site was the vertebral column, followed by the pelvic bone and lower extremity bones. The median survival rate after bone metastases diagnosis ranged from 3.0 to 45 months. The most frequent treatments were palliative and included radiotherapy and chemotherapy, followed by surgery. The findings of this review give a first dataset for a greater understanding of GC bone metastases that could help clinicians move toward a more “personalized” and thus more effective patient management. |
first_indexed | 2024-03-10T07:46:35Z |
format | Article |
id | doaj.art-904821b64e0c4911979c7c8e98a585e0 |
institution | Directory Open Access Journal |
issn | 2075-4418 |
language | English |
last_indexed | 2024-03-10T07:46:35Z |
publishDate | 2021-09-01 |
publisher | MDPI AG |
record_format | Article |
series | Diagnostics |
spelling | doaj.art-904821b64e0c4911979c7c8e98a585e02023-11-22T12:39:56ZengMDPI AGDiagnostics2075-44182021-09-01119162610.3390/diagnostics11091626Clinical Characteristics, Treatment Modalities, and Potential Contributing and Prognostic Factors in Patients with Bone Metastases from Gynecological Cancers: A Systematic ReviewFrancesca Salamanna0Anna Myriam Perrone1Deyanira Contartese2Veronica Borsari3Alessandro Gasbarrini4Silvia Terzi5Pierandrea De Iaco6Milena Fini7Complex Structure Surgical Sciences and Technologies, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, ItalyDivision of Oncologic Gynecology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, ItalyComplex Structure Surgical Sciences and Technologies, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, ItalyComplex Structure Surgical Sciences and Technologies, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, ItalyDepartment of Oncologic and Degenerative Spine Surgery, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, ItalyDepartment of Oncologic and Degenerative Spine Surgery, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, ItalyDivision of Oncologic Gynecology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, ItalyComplex Structure Surgical Sciences and Technologies, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, ItalyThe purpose of this study is to review the clinical characteristics, treatment modalities, and potential contributing and prognostic factors of bone metastases from gynecological cancers (GCs). A systematic literature search on PubMed, Scopus, Web of Science Core Collection and Cochrane Central Register of Controlled Trials databases was conducted. Thirty-one studies, all retrospective, were included in this review, for a total of 2880 patients with GC bone metastases. Primary tumors leading to bone metastases included endometrial cancer (EC), cervical cancer (CC), ovarian cancer (OC), uterine sarcoma (US) and vulvar cancer (VuC), mainly with an International Federation of Gynecology and Obstetrics (FIGO) Stage of III and IV. The main bone metastatic lesion site was the vertebral column, followed by the pelvic bone and lower extremity bones. The median survival rate after bone metastases diagnosis ranged from 3.0 to 45 months. The most frequent treatments were palliative and included radiotherapy and chemotherapy, followed by surgery. The findings of this review give a first dataset for a greater understanding of GC bone metastases that could help clinicians move toward a more “personalized” and thus more effective patient management.https://www.mdpi.com/2075-4418/11/9/1626bone metastasesgynecological cancerclinical studiessystematic review |
spellingShingle | Francesca Salamanna Anna Myriam Perrone Deyanira Contartese Veronica Borsari Alessandro Gasbarrini Silvia Terzi Pierandrea De Iaco Milena Fini Clinical Characteristics, Treatment Modalities, and Potential Contributing and Prognostic Factors in Patients with Bone Metastases from Gynecological Cancers: A Systematic Review Diagnostics bone metastases gynecological cancer clinical studies systematic review |
title | Clinical Characteristics, Treatment Modalities, and Potential Contributing and Prognostic Factors in Patients with Bone Metastases from Gynecological Cancers: A Systematic Review |
title_full | Clinical Characteristics, Treatment Modalities, and Potential Contributing and Prognostic Factors in Patients with Bone Metastases from Gynecological Cancers: A Systematic Review |
title_fullStr | Clinical Characteristics, Treatment Modalities, and Potential Contributing and Prognostic Factors in Patients with Bone Metastases from Gynecological Cancers: A Systematic Review |
title_full_unstemmed | Clinical Characteristics, Treatment Modalities, and Potential Contributing and Prognostic Factors in Patients with Bone Metastases from Gynecological Cancers: A Systematic Review |
title_short | Clinical Characteristics, Treatment Modalities, and Potential Contributing and Prognostic Factors in Patients with Bone Metastases from Gynecological Cancers: A Systematic Review |
title_sort | clinical characteristics treatment modalities and potential contributing and prognostic factors in patients with bone metastases from gynecological cancers a systematic review |
topic | bone metastases gynecological cancer clinical studies systematic review |
url | https://www.mdpi.com/2075-4418/11/9/1626 |
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