Type-specific prevalence of Human Papillomavirus infection among women in the Northwest Territories, Canada
Summary: Background: Certain types of Human Papillomavirus (HPV) are highly associated with cervical cancer and precursor lesions (dysplasia), but the distribution of HPVs in Northern Canada is largely unknown. This study determined the prevalences of HPV infection due to different virus types and...
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| Format: | Article |
| Language: | English |
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Elsevier
2011-11-01
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| Series: | Journal of Infection and Public Health |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1876034111001018 |
| _version_ | 1831690376378843136 |
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| author | Y. Jiang P. Brassard A. Severini V. Goleski M. Santos A. Leamon S. Chatwood C. Lys G. Johnson T. Wong A. Kotaska K. Kandola Y. Mao |
| author_facet | Y. Jiang P. Brassard A. Severini V. Goleski M. Santos A. Leamon S. Chatwood C. Lys G. Johnson T. Wong A. Kotaska K. Kandola Y. Mao |
| author_sort | Y. Jiang |
| collection | DOAJ |
| description | Summary: Background: Certain types of Human Papillomavirus (HPV) are highly associated with cervical cancer and precursor lesions (dysplasia), but the distribution of HPVs in Northern Canada is largely unknown. This study determined the prevalences of HPV infection due to different virus types and the association of different virus types with cervical dysplasia in the Northwest Territories (NWT). Methods: Between April 2008 and March 2009, women who underwent routine Pap testing in the NWT were included in the study. An in-house Luminex assay detected type-specific HPV infections. The HPV prevalence rates and population attributable risk fractions were calculated. Results: In 5725 bio-samples, the overall HPV prevalence was 24.2%, and of the HPV-positive samples, 76.6% harbored high-risk types, 35.2% harbored multi-type infections, and 21.6% harbored HPV16 or 18 infections. The HPV prevalence was approximately 50% higher among Aboriginal than non-Aboriginal women. The age-specific HPV prevalence exhibited a U-shape distribution in the Aboriginal group. The prevalence of HPV16 or 18 infections found in high-grade lesions was 34.1%. Among this study population, 89.5% of the cases with cervical dysplasia were attributable to HPV infection, with 27.1% attributable to HPV16/18. Conclusion: The high prevalence of high-risk HPV in this population, particularly in the Aboriginal group, will require further studies to identify specific predictors of infection. Keywords: Human Papillomavirus, Type-specific, Prevalence |
| first_indexed | 2024-12-20T11:10:30Z |
| format | Article |
| id | doaj.art-9048e719558c45a9abcaeb64d3adef9f |
| institution | Directory Open Access Journal |
| issn | 1876-0341 |
| language | English |
| last_indexed | 2024-12-20T11:10:30Z |
| publishDate | 2011-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Infection and Public Health |
| spelling | doaj.art-9048e719558c45a9abcaeb64d3adef9f2022-12-21T19:42:47ZengElsevierJournal of Infection and Public Health1876-03412011-11-0145219227Type-specific prevalence of Human Papillomavirus infection among women in the Northwest Territories, CanadaY. Jiang0P. Brassard1A. Severini2V. Goleski3M. Santos4A. Leamon5S. Chatwood6C. Lys7G. Johnson8T. Wong9A. Kotaska10K. Kandola11Y. Mao12Centre for Chronic Disease Prevention and Control, Public Health Agency of Canada (PHAC), 785 Carling Ave., Ottawa, ON, Canada K1A 0K9Division of Clinical Epidemiology, McGill University Health Center, 687 Des Pins West, Montreal, QC, Canada H3A 1A1National Microbiology Laboratory, PHAC, 1015 Arlington Street, Winnipeg, MB, Canada R3E 3R2National Microbiology Laboratory, PHAC, 1015 Arlington Street, Winnipeg, MB, Canada R3E 3R2Department of Health and Social Services, CST-6, Yellowknife, NWT, Canada X1A 2L9Department of Health and Social Services, CST-6, Yellowknife, NWT, Canada X1A 2L9Institute for Circumpolar Health Research, 102-5405 49 Ave., Yellowknife, NWT, Canada X1A 3X7; University of Toronto, 155 College Street, Toronto, ON, Canada M5T 3M7Institute for Circumpolar Health Research, 102-5405 49 Ave., Yellowknife, NWT, Canada X1A 3X7Dynacare Kasper Medical Laboratories, 200.10150 102 Street, Edmonton, AB, Canada T5J 5E2University of Toronto, 155 College Street, Toronto, ON, Canada M5T 3M7; Centre for Communicable Diseases and Infection Control, PHAC, 200 Eglantine Driveway, Tunney's Pasture, Ottawa, ON, Canada K1A 0K9Department of Obstetrics and Gynaecology, Stanton Territorial Hospital, BOX 10, Yellowknife, NWT, Canada X1A 2N1Department of Health and Social Services, CST-6, Yellowknife, NWT, Canada X1A 2L9Centre for Chronic Disease Prevention and Control, Public Health Agency of Canada (PHAC), 785 Carling Ave., Ottawa, ON, Canada K1A 0K9; Corresponding author. Tel.: +1 61 3 957 1765; fax: +1 61 3 941 2633.Summary: Background: Certain types of Human Papillomavirus (HPV) are highly associated with cervical cancer and precursor lesions (dysplasia), but the distribution of HPVs in Northern Canada is largely unknown. This study determined the prevalences of HPV infection due to different virus types and the association of different virus types with cervical dysplasia in the Northwest Territories (NWT). Methods: Between April 2008 and March 2009, women who underwent routine Pap testing in the NWT were included in the study. An in-house Luminex assay detected type-specific HPV infections. The HPV prevalence rates and population attributable risk fractions were calculated. Results: In 5725 bio-samples, the overall HPV prevalence was 24.2%, and of the HPV-positive samples, 76.6% harbored high-risk types, 35.2% harbored multi-type infections, and 21.6% harbored HPV16 or 18 infections. The HPV prevalence was approximately 50% higher among Aboriginal than non-Aboriginal women. The age-specific HPV prevalence exhibited a U-shape distribution in the Aboriginal group. The prevalence of HPV16 or 18 infections found in high-grade lesions was 34.1%. Among this study population, 89.5% of the cases with cervical dysplasia were attributable to HPV infection, with 27.1% attributable to HPV16/18. Conclusion: The high prevalence of high-risk HPV in this population, particularly in the Aboriginal group, will require further studies to identify specific predictors of infection. Keywords: Human Papillomavirus, Type-specific, Prevalencehttp://www.sciencedirect.com/science/article/pii/S1876034111001018 |
| spellingShingle | Y. Jiang P. Brassard A. Severini V. Goleski M. Santos A. Leamon S. Chatwood C. Lys G. Johnson T. Wong A. Kotaska K. Kandola Y. Mao Type-specific prevalence of Human Papillomavirus infection among women in the Northwest Territories, Canada Journal of Infection and Public Health |
| title | Type-specific prevalence of Human Papillomavirus infection among women in the Northwest Territories, Canada |
| title_full | Type-specific prevalence of Human Papillomavirus infection among women in the Northwest Territories, Canada |
| title_fullStr | Type-specific prevalence of Human Papillomavirus infection among women in the Northwest Territories, Canada |
| title_full_unstemmed | Type-specific prevalence of Human Papillomavirus infection among women in the Northwest Territories, Canada |
| title_short | Type-specific prevalence of Human Papillomavirus infection among women in the Northwest Territories, Canada |
| title_sort | type specific prevalence of human papillomavirus infection among women in the northwest territories canada |
| url | http://www.sciencedirect.com/science/article/pii/S1876034111001018 |
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