The prevalence of HDV among HBsAg-positive populations with and without HIV-1 in China
Background: Existing research has provided evidence of changes in hepatitis delta virus (HDV) prevalence worldwide. This study aimed to investigate the prevalence and molecular characteristics of HDV to elucidate its spread in China. Methods: A total of 3,000 samples were collected from 2,241 HBV mo...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-03-01
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| Series: | International Journal of Infectious Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971223008172 |
| _version_ | 1827346898949767168 |
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| author | Yan Wang Guizhou Shen Ruichao Lu Jun Liu Feng Zhang Hui Wang Weiping Cai Fujie Zhang |
| author_facet | Yan Wang Guizhou Shen Ruichao Lu Jun Liu Feng Zhang Hui Wang Weiping Cai Fujie Zhang |
| author_sort | Yan Wang |
| collection | DOAJ |
| description | Background: Existing research has provided evidence of changes in hepatitis delta virus (HDV) prevalence worldwide. This study aimed to investigate the prevalence and molecular characteristics of HDV to elucidate its spread in China. Methods: A total of 3,000 samples were collected from 2,241 HBV monoinfections and 759 HBV/HIV-1 coinfections across 13 sites in northern, southern, western, and southwestern China. Serological and virological prevalence were determined by detecting anti-HDV antibodies and HDV RNA. Results: The study revealed a 2.63% (95% CI: 2.06–3.21) seroprevalence of HDV among HBV infections in China, exhibiting regional variation. HDV seroprevalence was notably higher at 7.91% (95% CI: 5.98–9.83) in HBV and HIV-1 coinfections. Region and HIV-1 infection were identified as risk factors for HDV infection. Virological prevalence was 0.67% (95% CI: 0.38–0.96) in HBV infections and 2.24% (95% CI: 1.18–3.29) in HBV/HIV-1 coinfections. The predominant HDV genotype in China was HDV-2a, followed by HDV-1. Participants with anti-HDV positivity demonstrated significantly higher proportions of abnormal liver dysfunction and elevated HBV DNA load (P < 0.001) compared to anti-HDV-negative participants. Conclusions: This study highlights the HDV epidemic in China, sheds light on its geographical distribution and high-risk populations, and provides insights for developing strategies to manage the spread of HDV in the country. |
| first_indexed | 2024-03-07T23:39:29Z |
| format | Article |
| id | doaj.art-904a9724289a40eb87b5de3ee483429f |
| institution | Directory Open Access Journal |
| issn | 1201-9712 |
| language | English |
| last_indexed | 2024-03-07T23:39:29Z |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-904a9724289a40eb87b5de3ee483429f2024-02-20T04:18:51ZengElsevierInternational Journal of Infectious Diseases1201-97122024-03-011407077The prevalence of HDV among HBsAg-positive populations with and without HIV-1 in ChinaYan Wang0Guizhou Shen1Ruichao Lu2Jun Liu3Feng Zhang4Hui Wang5Weiping Cai6Fujie Zhang7Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China; Clinical and Research Center for Infectious Diseases, Beijing Ditan Hospital, Beijing, ChinaThe first People's Hospital of Liangshan Yi Autonomous Prefecture, Sichuan, ChinaChest Hospital of Guangxi Zhuang Autonomous Region, Guangxi, ChinaDepartment of HIV/AIDS, Third People's Hospital of Kunming, Yunnan, ChinaHealth Commission, Xinjiang Uyghur Autonomous Region, Xinjiang, ChinaThird People's Hospital of Shenzhen, Second Affiliated Hospital of Southern University of Science and Technology, Guangdong, ChinaGuangzhou Eighth People's Hospital, Guangzhou Medical University, Guangdong, ChinaClinical and Research Center for Infectious Diseases, Beijing Ditan Hospital, Beijing, China; Corresponding author: Fujie Zhang, Beijing Ditan Hospital, Capital Medical University, No.8, Jingshun Dongjie, Chaoyang District, Beijing 100015, China, tel: +86 010 84322581/ fax: +86 010 84322581Background: Existing research has provided evidence of changes in hepatitis delta virus (HDV) prevalence worldwide. This study aimed to investigate the prevalence and molecular characteristics of HDV to elucidate its spread in China. Methods: A total of 3,000 samples were collected from 2,241 HBV monoinfections and 759 HBV/HIV-1 coinfections across 13 sites in northern, southern, western, and southwestern China. Serological and virological prevalence were determined by detecting anti-HDV antibodies and HDV RNA. Results: The study revealed a 2.63% (95% CI: 2.06–3.21) seroprevalence of HDV among HBV infections in China, exhibiting regional variation. HDV seroprevalence was notably higher at 7.91% (95% CI: 5.98–9.83) in HBV and HIV-1 coinfections. Region and HIV-1 infection were identified as risk factors for HDV infection. Virological prevalence was 0.67% (95% CI: 0.38–0.96) in HBV infections and 2.24% (95% CI: 1.18–3.29) in HBV/HIV-1 coinfections. The predominant HDV genotype in China was HDV-2a, followed by HDV-1. Participants with anti-HDV positivity demonstrated significantly higher proportions of abnormal liver dysfunction and elevated HBV DNA load (P < 0.001) compared to anti-HDV-negative participants. Conclusions: This study highlights the HDV epidemic in China, sheds light on its geographical distribution and high-risk populations, and provides insights for developing strategies to manage the spread of HDV in the country.http://www.sciencedirect.com/science/article/pii/S1201971223008172HDVHBVHIV-1Epidemiology |
| spellingShingle | Yan Wang Guizhou Shen Ruichao Lu Jun Liu Feng Zhang Hui Wang Weiping Cai Fujie Zhang The prevalence of HDV among HBsAg-positive populations with and without HIV-1 in China International Journal of Infectious Diseases HDV HBV HIV-1 Epidemiology |
| title | The prevalence of HDV among HBsAg-positive populations with and without HIV-1 in China |
| title_full | The prevalence of HDV among HBsAg-positive populations with and without HIV-1 in China |
| title_fullStr | The prevalence of HDV among HBsAg-positive populations with and without HIV-1 in China |
| title_full_unstemmed | The prevalence of HDV among HBsAg-positive populations with and without HIV-1 in China |
| title_short | The prevalence of HDV among HBsAg-positive populations with and without HIV-1 in China |
| title_sort | prevalence of hdv among hbsag positive populations with and without hiv 1 in china |
| topic | HDV HBV HIV-1 Epidemiology |
| url | http://www.sciencedirect.com/science/article/pii/S1201971223008172 |
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