Selective Engagement of FcγRIV by a M2e-Specific Single Domain Antibody Construct Protects Against Influenza A Virus Infection

Selective Engagement of FcγRIV by a M2e-Specific Single Domain Antibody Construct Protects Against Influenza A Virus Infection

Lower respiratory tract infections, such as infections caused by influenza A viruses, are a constant threat for public health. Antivirals are indispensable to control disease caused by epidemic as well as pandemic influenza A. We developed a novel anti-influenza A virus approach based on an engineer...

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Bibliographic Details
Main Authors: Dorien De Vlieger, Katja Hoffmann, Inge Van Molle, Wim Nerinckx, Lien Van Hoecke, Marlies Ballegeer, Sarah Creytens, Han Remaut, Hartmut Hengel, Bert Schepens, Xavier Saelens
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Immunology
Subjects:
influenza
matrix protein 2 ectodomain
single domain antibody
Fcγ receptor
effector functions
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02920/full

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