Orthostatic stability with intravenous levodopa
Intravenous levodopa has been used in a multitude of research studies due to its more predictable pharmacokinetics compared to the oral form, which is used frequently as a treatment for Parkinson’s disease (PD). Levodopa is the precursor for dopamine, and intravenous dopamine would strongly affect v...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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PeerJ Inc.
2015-08-01
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| Series: | PeerJ |
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| Online Access: | https://peerj.com/articles/1198.pdf |
| _version_ | 1797425687631495168 |
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| author | Shan H. Siddiqi Mary L. Creech Kevin J. Black |
| author_facet | Shan H. Siddiqi Mary L. Creech Kevin J. Black |
| author_sort | Shan H. Siddiqi |
| collection | DOAJ |
| description | Intravenous levodopa has been used in a multitude of research studies due to its more predictable pharmacokinetics compared to the oral form, which is used frequently as a treatment for Parkinson’s disease (PD). Levodopa is the precursor for dopamine, and intravenous dopamine would strongly affect vascular tone, but peripheral decarboxylase inhibitors are intended to block such effects. Pulse and blood pressure, with orthostatic changes, were recorded before and after intravenous levodopa or placebo—after oral carbidopa—in 13 adults with a chronic tic disorder and 16 tic-free adult control subjects. Levodopa caused no statistically or clinically significant changes in blood pressure or pulse. These data add to previous data that support the safety of i.v. levodopa when given with adequate peripheral inhibition of DOPA decarboxylase. |
| first_indexed | 2024-03-09T08:19:46Z |
| format | Article |
| id | doaj.art-904d1af465094a108db34b4a314cfa61 |
| institution | Directory Open Access Journal |
| issn | 2167-8359 |
| language | English |
| last_indexed | 2024-03-09T08:19:46Z |
| publishDate | 2015-08-01 |
| publisher | PeerJ Inc. |
| record_format | Article |
| series | PeerJ |
| spelling | doaj.art-904d1af465094a108db34b4a314cfa612023-12-02T21:53:49ZengPeerJ Inc.PeerJ2167-83592015-08-013e119810.7717/peerj.1198Orthostatic stability with intravenous levodopaShan H. Siddiqi0Mary L. Creech1Kevin J. Black2Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USADepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USADepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USAIntravenous levodopa has been used in a multitude of research studies due to its more predictable pharmacokinetics compared to the oral form, which is used frequently as a treatment for Parkinson’s disease (PD). Levodopa is the precursor for dopamine, and intravenous dopamine would strongly affect vascular tone, but peripheral decarboxylase inhibitors are intended to block such effects. Pulse and blood pressure, with orthostatic changes, were recorded before and after intravenous levodopa or placebo—after oral carbidopa—in 13 adults with a chronic tic disorder and 16 tic-free adult control subjects. Levodopa caused no statistically or clinically significant changes in blood pressure or pulse. These data add to previous data that support the safety of i.v. levodopa when given with adequate peripheral inhibition of DOPA decarboxylase.https://peerj.com/articles/1198.pdfCarbidopaLevodopaTourette syndromeHeart rateRandomized controlled trialBlood pressure |
| spellingShingle | Shan H. Siddiqi Mary L. Creech Kevin J. Black Orthostatic stability with intravenous levodopa PeerJ Carbidopa Levodopa Tourette syndrome Heart rate Randomized controlled trial Blood pressure |
| title | Orthostatic stability with intravenous levodopa |
| title_full | Orthostatic stability with intravenous levodopa |
| title_fullStr | Orthostatic stability with intravenous levodopa |
| title_full_unstemmed | Orthostatic stability with intravenous levodopa |
| title_short | Orthostatic stability with intravenous levodopa |
| title_sort | orthostatic stability with intravenous levodopa |
| topic | Carbidopa Levodopa Tourette syndrome Heart rate Randomized controlled trial Blood pressure |
| url | https://peerj.com/articles/1198.pdf |
| work_keys_str_mv | AT shanhsiddiqi orthostaticstabilitywithintravenouslevodopa AT marylcreech orthostaticstabilitywithintravenouslevodopa AT kevinjblack orthostaticstabilitywithintravenouslevodopa |