Comparison of the genomic alterations present in tumor samples from patients with metastatic inflammatory versus non-inflammatory breast cancer reveals AURKA as a potential treatment target
Inflammatory breast cancer (IBC) is a rare but aggressive subtype of breast cancer, mainly characterized using primary tumor samples. Here, using public datasets, we compared the genomic alterations in primary and metastatic samples from patients with metastatic IBC versus patients with metastatic n...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-06-01
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| Series: | Breast |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0960977623000103 |
| _version_ | 1797804677332467712 |
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| author | François Richard Maxim De Schepper Marion Maetens Sophia Leduc Edoardo Isnaldi Tatjana Geukens Karen Van Baelen Ha-Linh Nguyen Peter Vermeulen Steven Van Laere François Bertucci Naoto Ueno Luc Dirix Giuseppe Floris Elia Biganzoli Christine Desmedt |
| author_facet | François Richard Maxim De Schepper Marion Maetens Sophia Leduc Edoardo Isnaldi Tatjana Geukens Karen Van Baelen Ha-Linh Nguyen Peter Vermeulen Steven Van Laere François Bertucci Naoto Ueno Luc Dirix Giuseppe Floris Elia Biganzoli Christine Desmedt |
| author_sort | François Richard |
| collection | DOAJ |
| description | Inflammatory breast cancer (IBC) is a rare but aggressive subtype of breast cancer, mainly characterized using primary tumor samples. Here, using public datasets, we compared the genomic alterations in primary and metastatic samples from patients with metastatic IBC versus patients with metastatic non-IBC. We observed a higher frequency of AURKA amplification in IBC. We further showed that AURKA amplification was associated with increased AURKA mRNA expression, which we demonstrated was higher in IBC. Finally, higher protein expression of AURKA was associated with worse prognosis in patients with IBC. These findings deserve further investigation given the existence of AURKA-inhibitors. |
| first_indexed | 2024-03-13T05:40:49Z |
| format | Article |
| id | doaj.art-904f298b2a5b4c66929aaedde7ed6e65 |
| institution | Directory Open Access Journal |
| issn | 1532-3080 |
| language | English |
| last_indexed | 2024-03-13T05:40:49Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Breast |
| spelling | doaj.art-904f298b2a5b4c66929aaedde7ed6e652023-06-14T04:32:38ZengElsevierBreast1532-30802023-06-0169476480Comparison of the genomic alterations present in tumor samples from patients with metastatic inflammatory versus non-inflammatory breast cancer reveals AURKA as a potential treatment targetFrançois Richard0Maxim De Schepper1Marion Maetens2Sophia Leduc3Edoardo Isnaldi4Tatjana Geukens5Karen Van Baelen6Ha-Linh Nguyen7Peter Vermeulen8Steven Van Laere9François Bertucci10Naoto Ueno11Luc Dirix12Giuseppe Floris13Elia Biganzoli14Christine Desmedt15Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, 3000, Leuven, BelgiumLaboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, 3000, Leuven, BelgiumLaboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, 3000, Leuven, BelgiumLaboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, 3000, Leuven, BelgiumLaboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, 3000, Leuven, Belgium; Department of Internal Medicine and Medical Specialties, University of Genoa, IT-16132, Genoa, ItalyLaboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, 3000, Leuven, BelgiumLaboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, 3000, Leuven, BelgiumLaboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, 3000, Leuven, BelgiumTranslational Cancer Research Unit, GZA Hospitals & CORE, MIPRO, University of Antwerp, Antwerp, Belgium; Department of Oncological Research, Oncology Center, GZA Hospitals Sint-Augustinus, Antwerp, BelgiumCenter for Oncological Research (CORE), Integrated Personalized and Precision Oncology Network (IPPON), University of Antwerp, BelgiumInstitut Paoli Calmettes, CRCM, INSERM U1068, CNRS UMR7258, Aix-Marseille Université, Marseille, FranceDepartment of Breast Medical Oncology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USATranslational Cancer Research Unit, GZA Hospitals & CORE, MIPRO, University of Antwerp, Antwerp, Belgium; Department of Oncological Research, Oncology Center, GZA Hospitals Sint-Augustinus, Antwerp, BelgiumDepartment of Imaging and Pathology, Laboratory of Translational Cell & Tissue Research and University Hospitals Leuven, KU Leuven, 3000, Leuven, BelgiumUnit of Medical Statistics, Biometry and Epidemiology, Department of Biomedical and Clinical Sciences (DIBIC) & DSRC, Ospedale “L. Sacco” LITA Campus, Università degli Studi di Milano, 20157, Milan, ItalyLaboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, 3000, Leuven, Belgium; Corresponding author. Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Herestraat 49, box 810, 3000, Leuven, Belgium.Inflammatory breast cancer (IBC) is a rare but aggressive subtype of breast cancer, mainly characterized using primary tumor samples. Here, using public datasets, we compared the genomic alterations in primary and metastatic samples from patients with metastatic IBC versus patients with metastatic non-IBC. We observed a higher frequency of AURKA amplification in IBC. We further showed that AURKA amplification was associated with increased AURKA mRNA expression, which we demonstrated was higher in IBC. Finally, higher protein expression of AURKA was associated with worse prognosis in patients with IBC. These findings deserve further investigation given the existence of AURKA-inhibitors.http://www.sciencedirect.com/science/article/pii/S0960977623000103Inflammatory breast cancerMetastatic breast cancerGenomic alterationsAURKA-Inhibitors |
| spellingShingle | François Richard Maxim De Schepper Marion Maetens Sophia Leduc Edoardo Isnaldi Tatjana Geukens Karen Van Baelen Ha-Linh Nguyen Peter Vermeulen Steven Van Laere François Bertucci Naoto Ueno Luc Dirix Giuseppe Floris Elia Biganzoli Christine Desmedt Comparison of the genomic alterations present in tumor samples from patients with metastatic inflammatory versus non-inflammatory breast cancer reveals AURKA as a potential treatment target Breast Inflammatory breast cancer Metastatic breast cancer Genomic alterations AURKA-Inhibitors |
| title | Comparison of the genomic alterations present in tumor samples from patients with metastatic inflammatory versus non-inflammatory breast cancer reveals AURKA as a potential treatment target |
| title_full | Comparison of the genomic alterations present in tumor samples from patients with metastatic inflammatory versus non-inflammatory breast cancer reveals AURKA as a potential treatment target |
| title_fullStr | Comparison of the genomic alterations present in tumor samples from patients with metastatic inflammatory versus non-inflammatory breast cancer reveals AURKA as a potential treatment target |
| title_full_unstemmed | Comparison of the genomic alterations present in tumor samples from patients with metastatic inflammatory versus non-inflammatory breast cancer reveals AURKA as a potential treatment target |
| title_short | Comparison of the genomic alterations present in tumor samples from patients with metastatic inflammatory versus non-inflammatory breast cancer reveals AURKA as a potential treatment target |
| title_sort | comparison of the genomic alterations present in tumor samples from patients with metastatic inflammatory versus non inflammatory breast cancer reveals aurka as a potential treatment target |
| topic | Inflammatory breast cancer Metastatic breast cancer Genomic alterations AURKA-Inhibitors |
| url | http://www.sciencedirect.com/science/article/pii/S0960977623000103 |
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