MHC class I-dressing is mediated via phosphatidylserine recognition and is enhanced by polyI:C
Summary: In addition to cross-presentation, cross-dressing plays an important role in the induction of CD8+ T cell immunity. In the process of cross-dressing, conventional dendritic cells (DCs) acquire major histocompatibility complex class I (MHCI) from other cells and subsequently prime CD8+ T cel...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-05-01
|
| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S258900422400926X |
| _version_ | 1797199842382970880 |
|---|---|
| author | Arisa Hori Saori Toyoura Miyu Fujiwara Ren Taniguchi Yasutaka Kano Tomoyoshi Yamano Rikinari Hanayama Masafumi Nakayama |
| author_facet | Arisa Hori Saori Toyoura Miyu Fujiwara Ren Taniguchi Yasutaka Kano Tomoyoshi Yamano Rikinari Hanayama Masafumi Nakayama |
| author_sort | Arisa Hori |
| collection | DOAJ |
| description | Summary: In addition to cross-presentation, cross-dressing plays an important role in the induction of CD8+ T cell immunity. In the process of cross-dressing, conventional dendritic cells (DCs) acquire major histocompatibility complex class I (MHCI) from other cells and subsequently prime CD8+ T cells via the pre-formed antigen-MHCI complexes without antigen processing. However, the mechanisms underlying the cross-dressing pathway, as well as the relative contributions of cross-presentation and cross-dressing to CD8+ T cell priming are not fully understood. Here, we demonstrate that DCs rapidly acquire MHCI-containing membrane fragments from dead cells via the phosphatidylserine recognition-dependent mechanism for cross-dressing. The MHCI dressing is enhanced by a TLR3 ligand polyinosinic-polycytidylic acid (polyI:C). Further, polyI:C promotes not only cross-presentation but also cross-dressing in vivo. Taken together, these results suggest that cross-dressing as well as cross-presentation is involved in inflammatory diseases associated with cell death and type I IFN production. |
| first_indexed | 2024-04-24T07:22:11Z |
| format | Article |
| id | doaj.art-905083a5f50048b1ad59d8b3cc304867 |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-04-24T07:22:11Z |
| publishDate | 2024-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-905083a5f50048b1ad59d8b3cc3048672024-04-21T04:14:30ZengElsevieriScience2589-00422024-05-01275109704MHC class I-dressing is mediated via phosphatidylserine recognition and is enhanced by polyI:CArisa Hori0Saori Toyoura1Miyu Fujiwara2Ren Taniguchi3Yasutaka Kano4Tomoyoshi Yamano5Rikinari Hanayama6Masafumi Nakayama7Laboratory of Immunology and Microbiology, College of Pharmaceutical Sciences, Ritsumeikan University, Kusatsu, Shiga 525-8577, JapanLaboratory of Immunology and Microbiology, College of Pharmaceutical Sciences, Ritsumeikan University, Kusatsu, Shiga 525-8577, JapanLaboratory of Immunology and Microbiology, College of Pharmaceutical Sciences, Ritsumeikan University, Kusatsu, Shiga 525-8577, JapanLaboratory of Immunology and Microbiology, College of Pharmaceutical Sciences, Ritsumeikan University, Kusatsu, Shiga 525-8577, JapanLaboratory of Immunology and Microbiology, College of Pharmaceutical Sciences, Ritsumeikan University, Kusatsu, Shiga 525-8577, JapanDepartment of Immunology, Kanazawa University Graduate School of Medical Sciences, 13-1 Takara-machi, Kanazawa, Ishikawa 920-8640, Japan; WPI Nano Life Science Institute (NanoLSI), Kanazawa University, Kakuma-machi, Kanazawa, Ishikawa 920-1192, JapanDepartment of Immunology, Kanazawa University Graduate School of Medical Sciences, 13-1 Takara-machi, Kanazawa, Ishikawa 920-8640, Japan; WPI Nano Life Science Institute (NanoLSI), Kanazawa University, Kakuma-machi, Kanazawa, Ishikawa 920-1192, JapanLaboratory of Immunology and Microbiology, College of Pharmaceutical Sciences, Ritsumeikan University, Kusatsu, Shiga 525-8577, Japan; Research Center for Animal Life Science, Shiga University of Medical Sciences, Seta, Tsukinowa-cho, Otsu, Shiga 520-2192, Japan; Corresponding authorSummary: In addition to cross-presentation, cross-dressing plays an important role in the induction of CD8+ T cell immunity. In the process of cross-dressing, conventional dendritic cells (DCs) acquire major histocompatibility complex class I (MHCI) from other cells and subsequently prime CD8+ T cells via the pre-formed antigen-MHCI complexes without antigen processing. However, the mechanisms underlying the cross-dressing pathway, as well as the relative contributions of cross-presentation and cross-dressing to CD8+ T cell priming are not fully understood. Here, we demonstrate that DCs rapidly acquire MHCI-containing membrane fragments from dead cells via the phosphatidylserine recognition-dependent mechanism for cross-dressing. The MHCI dressing is enhanced by a TLR3 ligand polyinosinic-polycytidylic acid (polyI:C). Further, polyI:C promotes not only cross-presentation but also cross-dressing in vivo. Taken together, these results suggest that cross-dressing as well as cross-presentation is involved in inflammatory diseases associated with cell death and type I IFN production.http://www.sciencedirect.com/science/article/pii/S258900422400926XImmunologyComponents of the immune systemCell biology |
| spellingShingle | Arisa Hori Saori Toyoura Miyu Fujiwara Ren Taniguchi Yasutaka Kano Tomoyoshi Yamano Rikinari Hanayama Masafumi Nakayama MHC class I-dressing is mediated via phosphatidylserine recognition and is enhanced by polyI:C iScience Immunology Components of the immune system Cell biology |
| title | MHC class I-dressing is mediated via phosphatidylserine recognition and is enhanced by polyI:C |
| title_full | MHC class I-dressing is mediated via phosphatidylserine recognition and is enhanced by polyI:C |
| title_fullStr | MHC class I-dressing is mediated via phosphatidylserine recognition and is enhanced by polyI:C |
| title_full_unstemmed | MHC class I-dressing is mediated via phosphatidylserine recognition and is enhanced by polyI:C |
| title_short | MHC class I-dressing is mediated via phosphatidylserine recognition and is enhanced by polyI:C |
| title_sort | mhc class i dressing is mediated via phosphatidylserine recognition and is enhanced by polyi c |
| topic | Immunology Components of the immune system Cell biology |
| url | http://www.sciencedirect.com/science/article/pii/S258900422400926X |
| work_keys_str_mv | AT arisahori mhcclassidressingismediatedviaphosphatidylserinerecognitionandisenhancedbypolyic AT saoritoyoura mhcclassidressingismediatedviaphosphatidylserinerecognitionandisenhancedbypolyic AT miyufujiwara mhcclassidressingismediatedviaphosphatidylserinerecognitionandisenhancedbypolyic AT rentaniguchi mhcclassidressingismediatedviaphosphatidylserinerecognitionandisenhancedbypolyic AT yasutakakano mhcclassidressingismediatedviaphosphatidylserinerecognitionandisenhancedbypolyic AT tomoyoshiyamano mhcclassidressingismediatedviaphosphatidylserinerecognitionandisenhancedbypolyic AT rikinarihanayama mhcclassidressingismediatedviaphosphatidylserinerecognitionandisenhancedbypolyic AT masafuminakayama mhcclassidressingismediatedviaphosphatidylserinerecognitionandisenhancedbypolyic |