Regulation of Schwann cell proliferation and migration via miR-195-5p-induced Crebl2 downregulation upon peripheral nerve damage

Regulation of Schwann cell proliferation and migration via miR-195-5p-induced Crebl2 downregulation upon peripheral nerve damage

BackgroundSchwann cells acquire a repair phenotype upon peripheral nerve injury (PNI), generating an optimal microenvironment that drives nerve repair. Multiple microRNAs (miRNAs) show differential expression in the damaged peripheral nerve, with critical regulatory functions in Schwann cell feature...

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Bibliographic Details
Main Authors: Shiying Li, Wenshuang Wu, Jing Zhang, Yu Chen, Yumeng Wu, Xinghui Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Cellular Neuroscience
Subjects:
miR-195-5p
Crebl2
Schwann cell
proliferation
migration
peripheral nerve injury
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2023.1173086/full

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