Emerging agents that target signaling pathways to eradicate colorectal cancer stem cells
Abstract Colorectal cancer (CRC) represents the third most commonly diagnosed cancer and the second leading cause of cancer death worldwide. The modern concept of cancer biology indicates that cancer is formed of a small population of cells called cancer stem cells (CSCs), which present both pluripo...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-12-01
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| Series: | Cancer Communications |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/cac2.12235 |
| _version_ | 1818270345906356224 |
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| author | Valdenizia R. Silva Luciano de S. Santos Rosane B. Dias Claudio A. Quadros Daniel P. Bezerra |
| author_facet | Valdenizia R. Silva Luciano de S. Santos Rosane B. Dias Claudio A. Quadros Daniel P. Bezerra |
| author_sort | Valdenizia R. Silva |
| collection | DOAJ |
| description | Abstract Colorectal cancer (CRC) represents the third most commonly diagnosed cancer and the second leading cause of cancer death worldwide. The modern concept of cancer biology indicates that cancer is formed of a small population of cells called cancer stem cells (CSCs), which present both pluripotency and self‐renewal properties. These cells are considered responsible for the progression of the disease, recurrence and tumor resistance. Interestingly, some cell signaling pathways participate in CRC survival, proliferation, and self‐renewal properties, and most of them are dysregulated in CSCs, including the Wingless (Wnt)/β‐catenin, Notch, Hedgehog, nuclear factor kappa B (NF‐κB), Janus kinase/signal transducer and activator of transcription (JAK/STAT), peroxisome proliferator‐activated receptor (PPAR), phosphatidyl‐inositol‐3‐kinase/Akt/mechanistic target of rapamycin (PI3K/Akt/mTOR), and transforming growth factor‐β (TGF‐β)/Smad pathways. In this review, we summarize the strategies for eradicating CRC stem cells by modulating these dysregulated pathways, which will contribute to the study of potential therapeutic schemes, combining conventional drugs with CSC‐targeting drugs, and allowing better cure rates in anti‐CRC therapy. |
| first_indexed | 2024-12-12T21:08:49Z |
| format | Article |
| id | doaj.art-9051fb6a26894dee851e4a001c0e533b |
| institution | Directory Open Access Journal |
| issn | 2523-3548 |
| language | English |
| last_indexed | 2024-12-12T21:08:49Z |
| publishDate | 2021-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Communications |
| spelling | doaj.art-9051fb6a26894dee851e4a001c0e533b2022-12-22T00:11:57ZengWileyCancer Communications2523-35482021-12-0141121275131310.1002/cac2.12235Emerging agents that target signaling pathways to eradicate colorectal cancer stem cellsValdenizia R. Silva0Luciano de S. Santos1Rosane B. Dias2Claudio A. Quadros3Daniel P. Bezerra4Gonçalo Moniz Institute Oswaldo Cruz Foundation (IGM‐FIOCRUZ/BA) Salvador Bahia 40296‐710 BrazilGonçalo Moniz Institute Oswaldo Cruz Foundation (IGM‐FIOCRUZ/BA) Salvador Bahia 40296‐710 BrazilGonçalo Moniz Institute Oswaldo Cruz Foundation (IGM‐FIOCRUZ/BA) Salvador Bahia 40296‐710 BrazilSão Rafael Hospital Rede D'Or/São Luiz Salvador Bahia 41253‐190 BrazilGonçalo Moniz Institute Oswaldo Cruz Foundation (IGM‐FIOCRUZ/BA) Salvador Bahia 40296‐710 BrazilAbstract Colorectal cancer (CRC) represents the third most commonly diagnosed cancer and the second leading cause of cancer death worldwide. The modern concept of cancer biology indicates that cancer is formed of a small population of cells called cancer stem cells (CSCs), which present both pluripotency and self‐renewal properties. These cells are considered responsible for the progression of the disease, recurrence and tumor resistance. Interestingly, some cell signaling pathways participate in CRC survival, proliferation, and self‐renewal properties, and most of them are dysregulated in CSCs, including the Wingless (Wnt)/β‐catenin, Notch, Hedgehog, nuclear factor kappa B (NF‐κB), Janus kinase/signal transducer and activator of transcription (JAK/STAT), peroxisome proliferator‐activated receptor (PPAR), phosphatidyl‐inositol‐3‐kinase/Akt/mechanistic target of rapamycin (PI3K/Akt/mTOR), and transforming growth factor‐β (TGF‐β)/Smad pathways. In this review, we summarize the strategies for eradicating CRC stem cells by modulating these dysregulated pathways, which will contribute to the study of potential therapeutic schemes, combining conventional drugs with CSC‐targeting drugs, and allowing better cure rates in anti‐CRC therapy.https://doi.org/10.1002/cac2.12235colorectalcancer stem cellscell signalingWnt/β‐catenin pathwayNotchHedgehog |
| spellingShingle | Valdenizia R. Silva Luciano de S. Santos Rosane B. Dias Claudio A. Quadros Daniel P. Bezerra Emerging agents that target signaling pathways to eradicate colorectal cancer stem cells Cancer Communications colorectal cancer stem cells cell signaling Wnt/β‐catenin pathway Notch Hedgehog |
| title | Emerging agents that target signaling pathways to eradicate colorectal cancer stem cells |
| title_full | Emerging agents that target signaling pathways to eradicate colorectal cancer stem cells |
| title_fullStr | Emerging agents that target signaling pathways to eradicate colorectal cancer stem cells |
| title_full_unstemmed | Emerging agents that target signaling pathways to eradicate colorectal cancer stem cells |
| title_short | Emerging agents that target signaling pathways to eradicate colorectal cancer stem cells |
| title_sort | emerging agents that target signaling pathways to eradicate colorectal cancer stem cells |
| topic | colorectal cancer stem cells cell signaling Wnt/β‐catenin pathway Notch Hedgehog |
| url | https://doi.org/10.1002/cac2.12235 |
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