Altered Nucleotide Insertion Mechanisms of Disease-Associated TERT Variants

Altered Nucleotide Insertion Mechanisms of Disease-Associated TERT Variants

Telomere biology disorders (TBDs) are a spectrum of diseases that arise from mutations in genes responsible for maintaining telomere integrity. Human telomerase reverse transcriptase (hTERT) adds nucleotides to chromosome ends and is frequently mutated in individuals with TBDs. Previous studies have...

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Bibliographic Details
Main Authors: Griffin A. Welfer, Veniamin A. Borin, Luis M. Cortez, Patricia L. Opresko, Pratul K. Agarwal, Bret D. Freudenthal
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Genes
Subjects:
telomeres
telomerase
telomere biology disorders
cancer
enzyme mechanisms
Online Access:https://www.mdpi.com/2073-4425/14/2/281

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