Lomitapide, a cholesterol-lowering drug, is an anticancer agent that induces autophagic cell death via inhibiting mTOR

Lomitapide, a cholesterol-lowering drug, is an anticancer agent that induces autophagic cell death via inhibiting mTOR

Abstract Autophagy is a biological process that maintains cellular homeostasis and regulates the internal cellular environment. Hyperactivating autophagy to trigger cell death has been a suggested therapeutic strategy for cancer treatment. Mechanistic target of rapamycin (mTOR) is a crucial protein...

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Bibliographic Details
Main Authors: Boah Lee, Seung Ju Park, Seulgi Lee, Jinwook Lee, Eunbeol Lee, Eun-Seon Yoo, Won-Suk Chung, Jong-Woo Sohn, Byung-Chul Oh, Seyun Kim
Format: Article
Language:English
Published: Nature Publishing Group 2022-07-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-022-05039-6

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