Considerations and Pitfalls in Selecting the Drug Vehicles for Evaluation of New Drug Candidates: Focus on in vivo Pharmaco-Toxicological Assays Based on the Rotarod Performance Test
Purpose - During the discovery and development of new drugs, compounds with low aqueous solubility pose special challenges in their pharmacological evaluation and, therefore, the selection of appropriate vehicles to administer the compounds of interest is determinant for the quality of the results g...
Main Authors: | Mariana Matias, Samuel Silvestre, Amílcar Falcão, Gilberto Alves |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2018-03-01
|
Series: | Journal of Pharmacy & Pharmaceutical Sciences |
Online Access: | https://journals.library.ualberta.ca/jpps/index.php/JPPS/article/view/29656 |
Similar Items
-
Pharmaco-toxicological Assessment of Antiparasitic Drug for Dogs and Cats "Gelmintal Mini Syrup"
by: G. B. Arisova, et al.
Published: (2020-10-01) -
Partial Reversible Inhibition of Enzymes and Its Metabolic and Pharmaco-Toxicological Implications
by: Patrick Masson, et al.
Published: (2023-08-01) -
Motor Behavioral Deficits in the Cuprizone Model: Validity of the Rotarod Test Paradigm
by: Concordia Lubrich, et al.
Published: (2022-09-01) -
Microfluidics as a Novel Tool for Biological and Toxicological Assays in Drug Discovery Processes: Focus on Microchip Electrophoresis
by: Giuseppe Caruso, et al.
Published: (2020-06-01) -
Antibiotics: Conventional Therapy and Natural Compounds with Antibacterial Activity—A Pharmaco-Toxicological Screening
by: Daniel Florin Pancu, et al.
Published: (2021-04-01)