Human papillomavirus prevalence and risk factors among HIV-negative and HIV-positive women residing in rural Eastern Cape, South Africa
Objectives: To investigate the prevalence of high-risk (HR) human papillomavirus (HPV) and factors associated with HR-HPV infection among women from rural Eastern Cape, South Africa. Methods: HPV prevalence was determined by Hybrid Capture 2 assay in cervical specimens from 417 women aged ≥30 years...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-06-01
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| Series: | International Journal of Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971220301090 |
| _version_ | 1818243368610693120 |
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| author | Ongeziwe Taku Charles B. Businge Mana L. Mdaka Keletso Phohlo Wisdom Basera Mirta Garcia-Jardon Tracy L. Meiring Ulf Gyllensten Anna-Lise Williamson Zizipho Z.A. Mbulawa |
| author_facet | Ongeziwe Taku Charles B. Businge Mana L. Mdaka Keletso Phohlo Wisdom Basera Mirta Garcia-Jardon Tracy L. Meiring Ulf Gyllensten Anna-Lise Williamson Zizipho Z.A. Mbulawa |
| author_sort | Ongeziwe Taku |
| collection | DOAJ |
| description | Objectives: To investigate the prevalence of high-risk (HR) human papillomavirus (HPV) and factors associated with HR-HPV infection among women from rural Eastern Cape, South Africa. Methods: HPV prevalence was determined by Hybrid Capture 2 assay in cervical specimens from 417 women aged ≥30 years (median 46 years) recruited from the community health clinic in the Eastern Cape. Results: HR-HPV prevalence was 28.5% (119/417), and HIV-positive women had significantly higher HR-HPV prevalence than HIV-negative women (40.6%, 63/155 vs 21.4%, 56/262, respectively; p = 0.001). HIV-positive status (odds ratio (OR) 2.52, 95% confidence interval (CI) 1.63–3.90), having ≥3 lifetime sexual partners (OR 2.12, 95% CI 1.16–3.89), having ≥1 sexual partner in the last month (OR 1.89, 95% CI 1.21–2.92), ≥4 times frequency of vaginal sex in the past 1 month (OR 2.40, 95% CI 1.32–4.35), and having a vaginal discharge currently/in the previous week (OR 2.13, 95% CI 1.18–3.85) increased the risk of HR-HPV infection. In the multivariate analysis, HIV positivity remained strongly associated with HR-HPV infection (OR 1.94, 95% CI 1.17–3.22). Conclusions: Risk factors related to sexual behaviors play a significant role in HR-HPV infection in this population. This report will inform health policymakers on HPV prevalence and contribute to discussions on the use of HPV testing as the primary cervical cancer screening test in South Africa. |
| first_indexed | 2024-12-12T14:00:01Z |
| format | Article |
| id | doaj.art-9055bf16fdfd49569a6a7e15dc7b9105 |
| institution | Directory Open Access Journal |
| issn | 1201-9712 |
| language | English |
| last_indexed | 2024-12-12T14:00:01Z |
| publishDate | 2020-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-9055bf16fdfd49569a6a7e15dc7b91052022-12-22T00:22:23ZengElsevierInternational Journal of Infectious Diseases1201-97122020-06-0195176182Human papillomavirus prevalence and risk factors among HIV-negative and HIV-positive women residing in rural Eastern Cape, South AfricaOngeziwe Taku0Charles B. Businge1Mana L. Mdaka2Keletso Phohlo3Wisdom Basera4Mirta Garcia-Jardon5Tracy L. Meiring6Ulf Gyllensten7Anna-Lise Williamson8Zizipho Z.A. Mbulawa9Division of Medical Virology, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South AfricaDepartment of Obstetrics and Gynaecology, Nelson Mandela Academic Hospital, Mthatha, South Africa; Department of Obstetrics and Gynaecology, Faculty of Health Sciences, Walter Sisulu University, Mthatha, South AfricaDepartment of Obstetrics and Gynaecology, Nelson Mandela Academic Hospital, Mthatha, South Africa; Department of Obstetrics and Gynaecology, Faculty of Health Sciences, Walter Sisulu University, Mthatha, South AfricaDivision of Medical Virology, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South AfricaSchool of Public Health and Family Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South AfricaDepartment of Pathology at Walter Sisulu University and National Health Laboratory Service, Mthatha, South AfricaDivision of Medical Virology, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South AfricaDepartment of Immunology, Genetics, and Pathology, Biomedical Centre, Science for Life Laboratory, Uppsala University, Uppsala, SwedenDivision of Medical Virology, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa; SAMRC Gynaecological Cancer Research Centre, University of Cape Town, Cape Town, South AfricaDivision of Medical Virology, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa; SAMRC Gynaecological Cancer Research Centre, University of Cape Town, Cape Town, South Africa; Centre for HIV and STIs, National Institute for Communicable Diseases, NHLS, Groote Schuur Hospital, Cape Town, South Africa; Department of Laboratory Medicine and Pathology, Faculty of Health Sciences, Walter Sisulu University, Mthatha, South Africa; National Health Laboratory Service, Nelson Mandela Academic Hospital, Mthatha, South Africa; Corresponding author at: Department of Laboratory Medicine and Pathology, National Health Laboratory Service and Walter Sisulu University, Nelson Mandela Academic Hospital, Fort Gale, Mthatha, South Africa.Objectives: To investigate the prevalence of high-risk (HR) human papillomavirus (HPV) and factors associated with HR-HPV infection among women from rural Eastern Cape, South Africa. Methods: HPV prevalence was determined by Hybrid Capture 2 assay in cervical specimens from 417 women aged ≥30 years (median 46 years) recruited from the community health clinic in the Eastern Cape. Results: HR-HPV prevalence was 28.5% (119/417), and HIV-positive women had significantly higher HR-HPV prevalence than HIV-negative women (40.6%, 63/155 vs 21.4%, 56/262, respectively; p = 0.001). HIV-positive status (odds ratio (OR) 2.52, 95% confidence interval (CI) 1.63–3.90), having ≥3 lifetime sexual partners (OR 2.12, 95% CI 1.16–3.89), having ≥1 sexual partner in the last month (OR 1.89, 95% CI 1.21–2.92), ≥4 times frequency of vaginal sex in the past 1 month (OR 2.40, 95% CI 1.32–4.35), and having a vaginal discharge currently/in the previous week (OR 2.13, 95% CI 1.18–3.85) increased the risk of HR-HPV infection. In the multivariate analysis, HIV positivity remained strongly associated with HR-HPV infection (OR 1.94, 95% CI 1.17–3.22). Conclusions: Risk factors related to sexual behaviors play a significant role in HR-HPV infection in this population. This report will inform health policymakers on HPV prevalence and contribute to discussions on the use of HPV testing as the primary cervical cancer screening test in South Africa.http://www.sciencedirect.com/science/article/pii/S1201971220301090High-risk human papillomavirusPrevalenceRisk factorsHIVSouth African women |
| spellingShingle | Ongeziwe Taku Charles B. Businge Mana L. Mdaka Keletso Phohlo Wisdom Basera Mirta Garcia-Jardon Tracy L. Meiring Ulf Gyllensten Anna-Lise Williamson Zizipho Z.A. Mbulawa Human papillomavirus prevalence and risk factors among HIV-negative and HIV-positive women residing in rural Eastern Cape, South Africa International Journal of Infectious Diseases High-risk human papillomavirus Prevalence Risk factors HIV South African women |
| title | Human papillomavirus prevalence and risk factors among HIV-negative and HIV-positive women residing in rural Eastern Cape, South Africa |
| title_full | Human papillomavirus prevalence and risk factors among HIV-negative and HIV-positive women residing in rural Eastern Cape, South Africa |
| title_fullStr | Human papillomavirus prevalence and risk factors among HIV-negative and HIV-positive women residing in rural Eastern Cape, South Africa |
| title_full_unstemmed | Human papillomavirus prevalence and risk factors among HIV-negative and HIV-positive women residing in rural Eastern Cape, South Africa |
| title_short | Human papillomavirus prevalence and risk factors among HIV-negative and HIV-positive women residing in rural Eastern Cape, South Africa |
| title_sort | human papillomavirus prevalence and risk factors among hiv negative and hiv positive women residing in rural eastern cape south africa |
| topic | High-risk human papillomavirus Prevalence Risk factors HIV South African women |
| url | http://www.sciencedirect.com/science/article/pii/S1201971220301090 |
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