Metabolite profiling of foslevodopa/foscarbidopa in plasma of healthy human participants by LC‐HRMS indicates no major differences compared to administration of levodopa/carbidopa intestinal gel

Metabolite profiling of foslevodopa/foscarbidopa in plasma of healthy human participants by LC‐HRMS indicates no major differences compared to administration of levodopa/carbidopa intestinal gel

Abstract Analysis was conducted to compare levodopa/carbidopa pharmacokinetics and drug‐related material in plasma of healthy participants after receiving a continuous infusion of Levodopa/Carbidopa Intestinal Gel (LCIG) to a continuous subcutaneous infusion of foslevodopa/foscarbidopa. Study sample...

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Bibliographic Details
Main Authors: John P. Savaryn, Richard L. Smith, Matthew Rosebraugh, Melina Neenan, Richard Burton, Kennan Marsh, David Wagner
Format: Article
Language:English
Published: Wiley 2024-04-01
Series:Pharmacology Research & Perspectives
Subjects:
carbidopa
foslevodopa
foscarbidopa
human
levodopa
metabolite profiling
Online Access:https://doi.org/10.1002/prp2.1190

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