Incidence of Peripheral Arterial Disease and Its Association with Pulse Pressure: A Prospective Cohort Study
BackgroundThe association of pulse pressure and peripheral arterial disease (PAD) has seldom been examined using a prospective design. This study aimed to investigate the association of pulse pressure with PAD incidence in an elderly general population.MethodsWe utilized data from a cohort conducted...
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| Format: | Article |
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Frontiers Media S.A.
2017-11-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fendo.2017.00333/full |
| _version_ | 1818482830056882176 |
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| author | Yong Mao Yixiang Huang Haining Yu Peng Xu Guangping Yu Jinming Yu Yiqiang Zhan |
| author_facet | Yong Mao Yixiang Huang Haining Yu Peng Xu Guangping Yu Jinming Yu Yiqiang Zhan |
| author_sort | Yong Mao |
| collection | DOAJ |
| description | BackgroundThe association of pulse pressure and peripheral arterial disease (PAD) has seldom been examined using a prospective design. This study aimed to investigate the association of pulse pressure with PAD incidence in an elderly general population.MethodsWe utilized data from a cohort conducted in Beijing with additionally 2-year follow-up time. PAD was defined as an ankle brachial index value <0.9 in either leg. Cox proportional hazard regression model was used to quantify the magnitude of pulse pressure on PAD incidence.ResultsDuring a 2-year follow-up time, 357 of 4,201 (8.5%) participants developed PAD with 105 (6.9%) men and 252 (9.4%) women, respectively. After adjusting for baseline age, sex, body mass index, hypertension, diabetes, total cholesterol, and high-density lipoprotein cholesterol, and smoking, the hazard ratio and 95% confidence interval for people with pulse pressure greater than 60 mmHg was 2.20 (1.53, 3.15) compared with those whose pulse pressure was less than 40 mmHg. A linear trend was observed for the association of pulse pressure with PAD.ConclusionHigher pulse pressure was associated with higher PAD incidence. |
| first_indexed | 2024-12-10T11:51:52Z |
| format | Article |
| id | doaj.art-905743ff5ca44259a3cd19d9fd4f80ad |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-10T11:51:52Z |
| publishDate | 2017-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-905743ff5ca44259a3cd19d9fd4f80ad2022-12-22T01:49:55ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922017-11-01810.3389/fendo.2017.00333300215Incidence of Peripheral Arterial Disease and Its Association with Pulse Pressure: A Prospective Cohort StudyYong Mao0Yixiang Huang1Haining Yu2Peng Xu3Guangping Yu4Jinming Yu5Yiqiang Zhan6Department of Epidemiology and Health Statistics, School of Public Health, Kunming Medical University, Kunming, ChinaSchool of Public Health, Sun Yat-sen University, Guangzhou, ChinaShandong Cancer Hospital Affiliated to Shandong University, Shandong Academy of Medical Sciences, Jinan, ChinaShandong Cancer Hospital Affiliated to Shandong University, Shandong Academy of Medical Sciences, Jinan, ChinaWuqing Center for Disease Control and Prevention, Tianjin, ChinaDepartment of Health Education and Health Behavior, School of Public Health, Fudan University, Shanghai, ChinaKarolinska Institutet, Stockholm, SwedenBackgroundThe association of pulse pressure and peripheral arterial disease (PAD) has seldom been examined using a prospective design. This study aimed to investigate the association of pulse pressure with PAD incidence in an elderly general population.MethodsWe utilized data from a cohort conducted in Beijing with additionally 2-year follow-up time. PAD was defined as an ankle brachial index value <0.9 in either leg. Cox proportional hazard regression model was used to quantify the magnitude of pulse pressure on PAD incidence.ResultsDuring a 2-year follow-up time, 357 of 4,201 (8.5%) participants developed PAD with 105 (6.9%) men and 252 (9.4%) women, respectively. After adjusting for baseline age, sex, body mass index, hypertension, diabetes, total cholesterol, and high-density lipoprotein cholesterol, and smoking, the hazard ratio and 95% confidence interval for people with pulse pressure greater than 60 mmHg was 2.20 (1.53, 3.15) compared with those whose pulse pressure was less than 40 mmHg. A linear trend was observed for the association of pulse pressure with PAD.ConclusionHigher pulse pressure was associated with higher PAD incidence.http://journal.frontiersin.org/article/10.3389/fendo.2017.00333/fullpulse pressureperipheral arterial diseaseankle brachial indexblood pressurecohort study |
| spellingShingle | Yong Mao Yixiang Huang Haining Yu Peng Xu Guangping Yu Jinming Yu Yiqiang Zhan Incidence of Peripheral Arterial Disease and Its Association with Pulse Pressure: A Prospective Cohort Study Frontiers in Endocrinology pulse pressure peripheral arterial disease ankle brachial index blood pressure cohort study |
| title | Incidence of Peripheral Arterial Disease and Its Association with Pulse Pressure: A Prospective Cohort Study |
| title_full | Incidence of Peripheral Arterial Disease and Its Association with Pulse Pressure: A Prospective Cohort Study |
| title_fullStr | Incidence of Peripheral Arterial Disease and Its Association with Pulse Pressure: A Prospective Cohort Study |
| title_full_unstemmed | Incidence of Peripheral Arterial Disease and Its Association with Pulse Pressure: A Prospective Cohort Study |
| title_short | Incidence of Peripheral Arterial Disease and Its Association with Pulse Pressure: A Prospective Cohort Study |
| title_sort | incidence of peripheral arterial disease and its association with pulse pressure a prospective cohort study |
| topic | pulse pressure peripheral arterial disease ankle brachial index blood pressure cohort study |
| url | http://journal.frontiersin.org/article/10.3389/fendo.2017.00333/full |
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