The ubiquitin system and Kaposi’s sarcoma-associated herpesvirus
Ubiquitination is a post-translational modification in which one or more ubiquitin molecules are covalently linked to lysine residues of target proteins. The ubiquitin system plays a key role in the regulation of protein degradation, including cell signaling, endocytosis, vesicle trafficking, apopto...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2012-02-01
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| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fmicb.2012.00066/full |
| _version_ | 1811199457128087552 |
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| author | Akira eAshizawa Chizuka eHigashi Kazuki eMasuda Rie eOhga Takahiro eTaira Masahiro eFujimuro Masahiro eFujimuro |
| author_facet | Akira eAshizawa Chizuka eHigashi Kazuki eMasuda Rie eOhga Takahiro eTaira Masahiro eFujimuro Masahiro eFujimuro |
| author_sort | Akira eAshizawa |
| collection | DOAJ |
| description | Ubiquitination is a post-translational modification in which one or more ubiquitin molecules are covalently linked to lysine residues of target proteins. The ubiquitin system plays a key role in the regulation of protein degradation, including cell signaling, endocytosis, vesicle trafficking, apoptosis, and immune responses. Bacterial and viral pathogens exploit the cellular ubiquitin system by encoding their own proteins to serve their survival and replication in infected cells. Recent studies have revealed that Kaposi’s sarcoma-associated herpesvirus (KSHV) manipulates the ubiquitin system of infected cells to facilitate cell proliferation, anti-apoptosis, and evasion from immunity. This review summarizes recent developments in our understanding of the molecular mechanisms used by KSHV to interact with the cellular ubiquitin machinery. |
| first_indexed | 2024-04-12T01:49:32Z |
| format | Article |
| id | doaj.art-90599917c8bf486796fab9c328703c92 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-04-12T01:49:32Z |
| publishDate | 2012-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-90599917c8bf486796fab9c328703c922022-12-22T03:52:59ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2012-02-01310.3389/fmicb.2012.0006619002The ubiquitin system and Kaposi’s sarcoma-associated herpesvirusAkira eAshizawa0Chizuka eHigashi1Kazuki eMasuda2Rie eOhga3Takahiro eTaira4Masahiro eFujimuro5Masahiro eFujimuro6University of YamanashiUniversity of YamanashiUniversity of YamanashiUniversity of YamanashiUniversity of YamanashiUniversity of YamanashiKyoto Pharmaceutical UniversityUbiquitination is a post-translational modification in which one or more ubiquitin molecules are covalently linked to lysine residues of target proteins. The ubiquitin system plays a key role in the regulation of protein degradation, including cell signaling, endocytosis, vesicle trafficking, apoptosis, and immune responses. Bacterial and viral pathogens exploit the cellular ubiquitin system by encoding their own proteins to serve their survival and replication in infected cells. Recent studies have revealed that Kaposi’s sarcoma-associated herpesvirus (KSHV) manipulates the ubiquitin system of infected cells to facilitate cell proliferation, anti-apoptosis, and evasion from immunity. This review summarizes recent developments in our understanding of the molecular mechanisms used by KSHV to interact with the cellular ubiquitin machinery.http://journal.frontiersin.org/Journal/10.3389/fmicb.2012.00066/fullPolyubiquitinUbiquitinKSHVHHV-8ProteasomeKaposi’s sarcoma-associated herpesvirus |
| spellingShingle | Akira eAshizawa Chizuka eHigashi Kazuki eMasuda Rie eOhga Takahiro eTaira Masahiro eFujimuro Masahiro eFujimuro The ubiquitin system and Kaposi’s sarcoma-associated herpesvirus Frontiers in Microbiology Polyubiquitin Ubiquitin KSHV HHV-8 Proteasome Kaposi’s sarcoma-associated herpesvirus |
| title | The ubiquitin system and Kaposi’s sarcoma-associated herpesvirus |
| title_full | The ubiquitin system and Kaposi’s sarcoma-associated herpesvirus |
| title_fullStr | The ubiquitin system and Kaposi’s sarcoma-associated herpesvirus |
| title_full_unstemmed | The ubiquitin system and Kaposi’s sarcoma-associated herpesvirus |
| title_short | The ubiquitin system and Kaposi’s sarcoma-associated herpesvirus |
| title_sort | ubiquitin system and kaposi s sarcoma associated herpesvirus |
| topic | Polyubiquitin Ubiquitin KSHV HHV-8 Proteasome Kaposi’s sarcoma-associated herpesvirus |
| url | http://journal.frontiersin.org/Journal/10.3389/fmicb.2012.00066/full |
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