Increased risk of stroke in patients with diffuse idiopathic skeletal hyperostosis: a nationwide population-based cohort study
Abstract Diffuse idiopathic skeletal hyperostosis (DISH) is frequently an incidental finding during X-ray examination. Although it has been shown to be associated with several chronic diseases, the hazard of cerebrovascular disease has seldom been explored. Our study aimed at determining the risk of...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-11-01
|
| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-00798-2 |
| _version_ | 1819040979759398912 |
|---|---|
| author | Yuan-Yang Cheng Ching-Heng Lin Po-Yi Tsai Yi-Huei Chen Shih-Yi Lin Shin-Tsu Chang |
| author_facet | Yuan-Yang Cheng Ching-Heng Lin Po-Yi Tsai Yi-Huei Chen Shih-Yi Lin Shin-Tsu Chang |
| author_sort | Yuan-Yang Cheng |
| collection | DOAJ |
| description | Abstract Diffuse idiopathic skeletal hyperostosis (DISH) is frequently an incidental finding during X-ray examination. Although it has been shown to be associated with several chronic diseases, the hazard of cerebrovascular disease has seldom been explored. Our study aimed at determining the risk of stroke conferred by DISH, which is a retrospective cohort study adopting the largest medical database in Taiwan. Patients with a diagnosis of DISH at least three times from 2005 to 2010 were identified as the study group, and those in the control group were selected by matching age and gender. Patients were followed up until the end of 2015 to trace the incidence of stroke. Cox regression analysis was performed to compute the hazard ratio of stroke. Among the included 5300 patients, 1060 had a diagnosis of DISH. Significantly higher prevalence rates of stroke, hypertension, diabetes, and hyperlipidemia were noted in these patients. Overall, DISH conferred a 1.68 times higher risk of developing stroke. The significantly higher hazard ratio could be identified in both genders whether hypertension existed or not. Even in those without comorbidities, DISH still conferred a significantly higher risk of cerebrovascular disease in the future, which should never be ignored when encountered during clinical practice. |
| first_indexed | 2024-12-21T09:17:42Z |
| format | Article |
| id | doaj.art-905a9b4b4d0547f1a55d6edd45eee930 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-21T09:17:42Z |
| publishDate | 2021-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-905a9b4b4d0547f1a55d6edd45eee9302022-12-21T19:09:07ZengNature PortfolioScientific Reports2045-23222021-11-011111710.1038/s41598-021-00798-2Increased risk of stroke in patients with diffuse idiopathic skeletal hyperostosis: a nationwide population-based cohort studyYuan-Yang Cheng0Ching-Heng Lin1Po-Yi Tsai2Yi-Huei Chen3Shih-Yi Lin4Shin-Tsu Chang5Department of Physical Medicine and Rehabilitation, Taichung Veterans General HospitalDepartment of Medical Research, Taichung Veterans General HospitalSchool of Medicine, National Yang Ming Chiao Tung UniversityDepartment of Medical Research, Taichung Veterans General HospitalSchool of Medicine, National Yang Ming Chiao Tung UniversityDepartment of Physical Medicine and Rehabilitation, Taichung Veterans General HospitalAbstract Diffuse idiopathic skeletal hyperostosis (DISH) is frequently an incidental finding during X-ray examination. Although it has been shown to be associated with several chronic diseases, the hazard of cerebrovascular disease has seldom been explored. Our study aimed at determining the risk of stroke conferred by DISH, which is a retrospective cohort study adopting the largest medical database in Taiwan. Patients with a diagnosis of DISH at least three times from 2005 to 2010 were identified as the study group, and those in the control group were selected by matching age and gender. Patients were followed up until the end of 2015 to trace the incidence of stroke. Cox regression analysis was performed to compute the hazard ratio of stroke. Among the included 5300 patients, 1060 had a diagnosis of DISH. Significantly higher prevalence rates of stroke, hypertension, diabetes, and hyperlipidemia were noted in these patients. Overall, DISH conferred a 1.68 times higher risk of developing stroke. The significantly higher hazard ratio could be identified in both genders whether hypertension existed or not. Even in those without comorbidities, DISH still conferred a significantly higher risk of cerebrovascular disease in the future, which should never be ignored when encountered during clinical practice.https://doi.org/10.1038/s41598-021-00798-2 |
| spellingShingle | Yuan-Yang Cheng Ching-Heng Lin Po-Yi Tsai Yi-Huei Chen Shih-Yi Lin Shin-Tsu Chang Increased risk of stroke in patients with diffuse idiopathic skeletal hyperostosis: a nationwide population-based cohort study Scientific Reports |
| title | Increased risk of stroke in patients with diffuse idiopathic skeletal hyperostosis: a nationwide population-based cohort study |
| title_full | Increased risk of stroke in patients with diffuse idiopathic skeletal hyperostosis: a nationwide population-based cohort study |
| title_fullStr | Increased risk of stroke in patients with diffuse idiopathic skeletal hyperostosis: a nationwide population-based cohort study |
| title_full_unstemmed | Increased risk of stroke in patients with diffuse idiopathic skeletal hyperostosis: a nationwide population-based cohort study |
| title_short | Increased risk of stroke in patients with diffuse idiopathic skeletal hyperostosis: a nationwide population-based cohort study |
| title_sort | increased risk of stroke in patients with diffuse idiopathic skeletal hyperostosis a nationwide population based cohort study |
| url | https://doi.org/10.1038/s41598-021-00798-2 |
| work_keys_str_mv | AT yuanyangcheng increasedriskofstrokeinpatientswithdiffuseidiopathicskeletalhyperostosisanationwidepopulationbasedcohortstudy AT chinghenglin increasedriskofstrokeinpatientswithdiffuseidiopathicskeletalhyperostosisanationwidepopulationbasedcohortstudy AT poyitsai increasedriskofstrokeinpatientswithdiffuseidiopathicskeletalhyperostosisanationwidepopulationbasedcohortstudy AT yihueichen increasedriskofstrokeinpatientswithdiffuseidiopathicskeletalhyperostosisanationwidepopulationbasedcohortstudy AT shihyilin increasedriskofstrokeinpatientswithdiffuseidiopathicskeletalhyperostosisanationwidepopulationbasedcohortstudy AT shintsuchang increasedriskofstrokeinpatientswithdiffuseidiopathicskeletalhyperostosisanationwidepopulationbasedcohortstudy |