Iron metabolism and cardiovascular disease: Basic to translational purviews and therapeutical approach
Iron interactions with the cardiovascular system were proposed about half a century ago, yet a clear-cut understanding of this micronutrient and its intricacies with acute and chronic events is still lacking. In chronic heart failure, patients with decreased iron stores appear to benefit from intrav...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | Revista Portuguesa de Cardiologia |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0870255122004565 |
| _version_ | 1811201413360910336 |
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| author | Mihai Lupu Diana Tudor Adriana Filip |
| author_facet | Mihai Lupu Diana Tudor Adriana Filip |
| author_sort | Mihai Lupu |
| collection | DOAJ |
| description | Iron interactions with the cardiovascular system were proposed about half a century ago, yet a clear-cut understanding of this micronutrient and its intricacies with acute and chronic events is still lacking. In chronic heart failure, patients with decreased iron stores appear to benefit from intravenous administration of metallic formulations, whereas acute diseases (e.g., myocardial infarction, stroke) are barely studied in randomized controlled trials in humans. However, proof-of-concept studies have indicated that the dual redox characteristics of iron could be involved in atherosclerosis, necrosis, and ferroptosis. To this end, we sought to review the currently available body of literature pertaining to these temporal profiles of heart diseases, as well as the pathophysiologic mechanism by which iron enacts, underlining key points related to treatment options. Resumo: As interações do ferro com o sistema cardiovascular foram propostas há cerca de meio século; falta ainda, no entanto, uma perceção clara sobre esse micronutriente e sobre as suas complexidades nos eventos agudos e crónicos. Na insuficiência cardíaca crónica os doentes com diminuição das reservas de ferro parecem beneficiar da administração intravenosa de formulações metálicas, enquanto as patologias agudas (por exemplo, enfarte do miocárdio, AVC) são pouco estudadas em ensaios controlados aleatorizados em humanos. No entanto, estudos de prova de conceito indicaram que a dupla característica redox do ferro poderia estar implicada na inaterosclerose, necrose e ferroptose. Para tal, procurámos rever o atual conjunto de literatura disponível sobre estes perfis temporais de doenças cardíacas, bem como o mecanismo fisiopatológico pelo qual o ferro exerce os seus efeitos, sublinhando pontos-chave relacionados com as opções de tratamento. |
| first_indexed | 2024-04-12T02:20:08Z |
| format | Article |
| id | doaj.art-905b17d0c5024837978ddfe49eb6d256 |
| institution | Directory Open Access Journal |
| issn | 0870-2551 |
| language | English |
| last_indexed | 2024-04-12T02:20:08Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Revista Portuguesa de Cardiologia |
| spelling | doaj.art-905b17d0c5024837978ddfe49eb6d2562022-12-22T03:52:08ZengElsevierRevista Portuguesa de Cardiologia0870-25512022-12-01411210371046Iron metabolism and cardiovascular disease: Basic to translational purviews and therapeutical approachMihai Lupu0Diana Tudor1Adriana Filip2Corresponding author.; Iuliu Hatieganu University of Medicine and Pharmacy, Department of Physiology, Cluj-Napoca, RomaniaIuliu Hatieganu University of Medicine and Pharmacy, Department of Physiology, Cluj-Napoca, RomaniaIuliu Hatieganu University of Medicine and Pharmacy, Department of Physiology, Cluj-Napoca, RomaniaIron interactions with the cardiovascular system were proposed about half a century ago, yet a clear-cut understanding of this micronutrient and its intricacies with acute and chronic events is still lacking. In chronic heart failure, patients with decreased iron stores appear to benefit from intravenous administration of metallic formulations, whereas acute diseases (e.g., myocardial infarction, stroke) are barely studied in randomized controlled trials in humans. However, proof-of-concept studies have indicated that the dual redox characteristics of iron could be involved in atherosclerosis, necrosis, and ferroptosis. To this end, we sought to review the currently available body of literature pertaining to these temporal profiles of heart diseases, as well as the pathophysiologic mechanism by which iron enacts, underlining key points related to treatment options. Resumo: As interações do ferro com o sistema cardiovascular foram propostas há cerca de meio século; falta ainda, no entanto, uma perceção clara sobre esse micronutriente e sobre as suas complexidades nos eventos agudos e crónicos. Na insuficiência cardíaca crónica os doentes com diminuição das reservas de ferro parecem beneficiar da administração intravenosa de formulações metálicas, enquanto as patologias agudas (por exemplo, enfarte do miocárdio, AVC) são pouco estudadas em ensaios controlados aleatorizados em humanos. No entanto, estudos de prova de conceito indicaram que a dupla característica redox do ferro poderia estar implicada na inaterosclerose, necrose e ferroptose. Para tal, procurámos rever o atual conjunto de literatura disponível sobre estes perfis temporais de doenças cardíacas, bem como o mecanismo fisiopatológico pelo qual o ferro exerce os seus efeitos, sublinhando pontos-chave relacionados com as opções de tratamento.http://www.sciencedirect.com/science/article/pii/S0870255122004565Insuficiência cardíacaFerroptoseMetabolismo do ferroEnfarte do miocárdioQuelação |
| spellingShingle | Mihai Lupu Diana Tudor Adriana Filip Iron metabolism and cardiovascular disease: Basic to translational purviews and therapeutical approach Revista Portuguesa de Cardiologia Insuficiência cardíaca Ferroptose Metabolismo do ferro Enfarte do miocárdio Quelação |
| title | Iron metabolism and cardiovascular disease: Basic to translational purviews and therapeutical approach |
| title_full | Iron metabolism and cardiovascular disease: Basic to translational purviews and therapeutical approach |
| title_fullStr | Iron metabolism and cardiovascular disease: Basic to translational purviews and therapeutical approach |
| title_full_unstemmed | Iron metabolism and cardiovascular disease: Basic to translational purviews and therapeutical approach |
| title_short | Iron metabolism and cardiovascular disease: Basic to translational purviews and therapeutical approach |
| title_sort | iron metabolism and cardiovascular disease basic to translational purviews and therapeutical approach |
| topic | Insuficiência cardíaca Ferroptose Metabolismo do ferro Enfarte do miocárdio Quelação |
| url | http://www.sciencedirect.com/science/article/pii/S0870255122004565 |
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