Gray matter reduction in bilateral insula mediating adverse psychiatric effects of body mass index in schizophrenia
Abstract Background Both schizophrenia (SZ) and overweight/obesity (OWB) have shown some structural alterations in similar brain regions. As higher body mass index (BMI) often contributes to worse psychiatric outcomes in SZ, this study was designed to examine the effects of OWB on gray matter volume...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-10-01
|
| Series: | BMC Psychiatry |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12888-022-04285-4 |
| _version_ | 1817983827695370240 |
|---|---|
| author | Hui Wu Guochao Dai Muyeseer Aizezi Juan Tang Ke Zou Yuhua Wu Xiaoli Wu |
| author_facet | Hui Wu Guochao Dai Muyeseer Aizezi Juan Tang Ke Zou Yuhua Wu Xiaoli Wu |
| author_sort | Hui Wu |
| collection | DOAJ |
| description | Abstract Background Both schizophrenia (SZ) and overweight/obesity (OWB) have shown some structural alterations in similar brain regions. As higher body mass index (BMI) often contributes to worse psychiatric outcomes in SZ, this study was designed to examine the effects of OWB on gray matter volume (GMV) in patients with SZ. Methods Two hundred fifty subjects were included and stratified into four groups (n = 69, SZ patients with OWB, SZ-OWB; n = 74, SZ patients with normal weight, SZ-NW; n = 54, healthy controls with OWB, HC-OWB; and n = 53, HC with NW, HC-NW). All participants were scanned using high-resolution T1-weighted sequence. The whole-brain voxel-based morphometry was applied to examine the GMV alterations, and a 2 × 2 full factorial analysis of variance was performed to identify the main effects of diagnosis (SZ vs HC), BMI (NW vs OWB) factors, and their interactions. Further, the post hoc analysis was conducted to compare the pairwise differences in GMV alterations. Results The main effects of diagnosis were located in right hippocampus, bilateral insula, rectus, median cingulate/paracingulate gyri and thalamus (SZ < HC); while the main effects of BMI were displayed in right amygdala, left hippocampus, bilateral insula, left lingual gyrus, and right superior temporal gyrus (OWB < NW). There were no significant diagnosis-by-BMI interaction effects in the present study, but the results showed that both SZ and OWB were additively associated with lower GMV in bilateral insula. Moreover, mediation analyses revealed the indirect effect of BMI on negative symptom via GMV reduction in bilateral insula. Conclusion This study further supports that higher BMI is associated with lower GMV, which may increase the risk of unfavourable disease courses in SZ. |
| first_indexed | 2024-04-13T23:38:09Z |
| format | Article |
| id | doaj.art-905bf0ca54d24d4e9f53a350018ec818 |
| institution | Directory Open Access Journal |
| issn | 1471-244X |
| language | English |
| last_indexed | 2024-04-13T23:38:09Z |
| publishDate | 2022-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Psychiatry |
| spelling | doaj.art-905bf0ca54d24d4e9f53a350018ec8182022-12-22T02:24:39ZengBMCBMC Psychiatry1471-244X2022-10-0122111210.1186/s12888-022-04285-4Gray matter reduction in bilateral insula mediating adverse psychiatric effects of body mass index in schizophreniaHui Wu0Guochao Dai1Muyeseer Aizezi2Juan Tang3Ke Zou4Yuhua Wu5Xiaoli Wu6Psychiatry Department, The Third Affiliated Hospital of Sun Yat-Sen UniversityThe Affiliated Kashi Hospital of Sun Yat-Sen UniversityThe Affiliated Kashi Hospital of Sun Yat-Sen UniversityThe Affiliated Kashi Hospital of Sun Yat-Sen UniversityThe Affiliated Kashi Hospital of Sun Yat-Sen UniversityThe Affiliated Kashi Hospital of Sun Yat-Sen UniversityPsychiatry Department, The Third Affiliated Hospital of Sun Yat-Sen UniversityAbstract Background Both schizophrenia (SZ) and overweight/obesity (OWB) have shown some structural alterations in similar brain regions. As higher body mass index (BMI) often contributes to worse psychiatric outcomes in SZ, this study was designed to examine the effects of OWB on gray matter volume (GMV) in patients with SZ. Methods Two hundred fifty subjects were included and stratified into four groups (n = 69, SZ patients with OWB, SZ-OWB; n = 74, SZ patients with normal weight, SZ-NW; n = 54, healthy controls with OWB, HC-OWB; and n = 53, HC with NW, HC-NW). All participants were scanned using high-resolution T1-weighted sequence. The whole-brain voxel-based morphometry was applied to examine the GMV alterations, and a 2 × 2 full factorial analysis of variance was performed to identify the main effects of diagnosis (SZ vs HC), BMI (NW vs OWB) factors, and their interactions. Further, the post hoc analysis was conducted to compare the pairwise differences in GMV alterations. Results The main effects of diagnosis were located in right hippocampus, bilateral insula, rectus, median cingulate/paracingulate gyri and thalamus (SZ < HC); while the main effects of BMI were displayed in right amygdala, left hippocampus, bilateral insula, left lingual gyrus, and right superior temporal gyrus (OWB < NW). There were no significant diagnosis-by-BMI interaction effects in the present study, but the results showed that both SZ and OWB were additively associated with lower GMV in bilateral insula. Moreover, mediation analyses revealed the indirect effect of BMI on negative symptom via GMV reduction in bilateral insula. Conclusion This study further supports that higher BMI is associated with lower GMV, which may increase the risk of unfavourable disease courses in SZ.https://doi.org/10.1186/s12888-022-04285-4SchizophreniaObesityGray matterInsulaNegative symptom |
| spellingShingle | Hui Wu Guochao Dai Muyeseer Aizezi Juan Tang Ke Zou Yuhua Wu Xiaoli Wu Gray matter reduction in bilateral insula mediating adverse psychiatric effects of body mass index in schizophrenia BMC Psychiatry Schizophrenia Obesity Gray matter Insula Negative symptom |
| title | Gray matter reduction in bilateral insula mediating adverse psychiatric effects of body mass index in schizophrenia |
| title_full | Gray matter reduction in bilateral insula mediating adverse psychiatric effects of body mass index in schizophrenia |
| title_fullStr | Gray matter reduction in bilateral insula mediating adverse psychiatric effects of body mass index in schizophrenia |
| title_full_unstemmed | Gray matter reduction in bilateral insula mediating adverse psychiatric effects of body mass index in schizophrenia |
| title_short | Gray matter reduction in bilateral insula mediating adverse psychiatric effects of body mass index in schizophrenia |
| title_sort | gray matter reduction in bilateral insula mediating adverse psychiatric effects of body mass index in schizophrenia |
| topic | Schizophrenia Obesity Gray matter Insula Negative symptom |
| url | https://doi.org/10.1186/s12888-022-04285-4 |
| work_keys_str_mv | AT huiwu graymatterreductioninbilateralinsulamediatingadversepsychiatriceffectsofbodymassindexinschizophrenia AT guochaodai graymatterreductioninbilateralinsulamediatingadversepsychiatriceffectsofbodymassindexinschizophrenia AT muyeseeraizezi graymatterreductioninbilateralinsulamediatingadversepsychiatriceffectsofbodymassindexinschizophrenia AT juantang graymatterreductioninbilateralinsulamediatingadversepsychiatriceffectsofbodymassindexinschizophrenia AT kezou graymatterreductioninbilateralinsulamediatingadversepsychiatriceffectsofbodymassindexinschizophrenia AT yuhuawu graymatterreductioninbilateralinsulamediatingadversepsychiatriceffectsofbodymassindexinschizophrenia AT xiaoliwu graymatterreductioninbilateralinsulamediatingadversepsychiatriceffectsofbodymassindexinschizophrenia |