Modafinil alleviates levodopa-induced excessive nighttime sleepiness and restores monoaminergic systems in a nocturnal animal model of Parkinson's disease
Treatment with dopaminergic agents result excessive daytime sleepiness (EDS) and some studies have shown the benefit of using modafinil for treating excessive daytime sleepiness of Parkinson's disease (PD) patient. We investigated whether modafinil have ameliorative properties against levodopa...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2018-04-01
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| Series: | Journal of Pharmacological Sciences |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1347861318300586 |
| _version_ | 1811199457330462720 |
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| author | Rina Ando Mohammed Emamussalehin Choudhury Yuki Yamanishi Win Thiri Kyaw Madoka Kubo Mariko Kannou Noriko Nishikawa Junya Tanaka Masahiro Nomoto Masahiro Nagai |
| author_facet | Rina Ando Mohammed Emamussalehin Choudhury Yuki Yamanishi Win Thiri Kyaw Madoka Kubo Mariko Kannou Noriko Nishikawa Junya Tanaka Masahiro Nomoto Masahiro Nagai |
| author_sort | Rina Ando |
| collection | DOAJ |
| description | Treatment with dopaminergic agents result excessive daytime sleepiness (EDS) and some studies have shown the benefit of using modafinil for treating excessive daytime sleepiness of Parkinson's disease (PD) patient. We investigated whether modafinil have ameliorative properties against levodopa induced excessive nighttime sleepiness (ENS) in MPTP-treated murine nocturnal PD model. Our EEG analyses of whole day recordings revealed that modafinil reduce ENS of this nocturnal PD models with levodopa medications. Therefore, we investigated whether, modafinil post-treatment followed by MPTP shows any effect on monoamine contents of brain and found to robustly increased noradrenaline (NA) concentration of MPTP treated mice. Modafinil post-treatment, in neurorestorative context (5 days post-lesion) led to increased striatal dopamine (DA) concentrations of MPTP-treated mice. Here, we first confirmed that modafinil ameliorates levodopa induced excessive sleepiness and restores monoaminergic systems. The arousal and anti-parkinsonian effects displayed by modafinil indicate that in combination with dopaminergic agents, modafinil co-administration may be worthwhile in trying to suppress the excessive daytime sleepiness and progressive dopaminergic neuron loss in PD. Keywords: Parkinson's disease, Excessive day time sleepiness, Monoamines, MPTP, Modafinil, Neurorestoration, Nocturnal |
| first_indexed | 2024-04-12T01:49:32Z |
| format | Article |
| id | doaj.art-905c855158434995a0937f980edf8a77 |
| institution | Directory Open Access Journal |
| issn | 1347-8613 |
| language | English |
| last_indexed | 2024-04-12T01:49:32Z |
| publishDate | 2018-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Pharmacological Sciences |
| spelling | doaj.art-905c855158434995a0937f980edf8a772022-12-22T03:52:59ZengElsevierJournal of Pharmacological Sciences1347-86132018-04-011364266271Modafinil alleviates levodopa-induced excessive nighttime sleepiness and restores monoaminergic systems in a nocturnal animal model of Parkinson's diseaseRina Ando0Mohammed Emamussalehin Choudhury1Yuki Yamanishi2Win Thiri Kyaw3Madoka Kubo4Mariko Kannou5Noriko Nishikawa6Junya Tanaka7Masahiro Nomoto8Masahiro Nagai9Department of Neurology and Clinical Pharmacology, Ehime University Graduate School of Medicine, 454 Shitsukawa, Toon, Ehime, 791-0295, JapanDepartment of Molecular and Cellular Physiology, Ehime University Graduate School of Medicine, 454 Shitsukawa, Toon, Ehime, 791-0295, Japan; Corresponding author. Department of Molecular and Cellular Physiology, Graduate School of Medicine, Ehime University, Toon, Ehime, 791-0295, Japan.Department of Neurology and Clinical Pharmacology, Ehime University Graduate School of Medicine, 454 Shitsukawa, Toon, Ehime, 791-0295, JapanDepartment of Neurology and Clinical Pharmacology, Ehime University Graduate School of Medicine, 454 Shitsukawa, Toon, Ehime, 791-0295, JapanDepartment of Neurology and Clinical Pharmacology, Ehime University Graduate School of Medicine, 454 Shitsukawa, Toon, Ehime, 791-0295, JapanDepartment of Neurology and Clinical Pharmacology, Ehime University Graduate School of Medicine, 454 Shitsukawa, Toon, Ehime, 791-0295, JapanDepartment of Neurology, National Center Hospital of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi, Kodaira, Tokyo, 187-8551, JapanDepartment of Molecular and Cellular Physiology, Ehime University Graduate School of Medicine, 454 Shitsukawa, Toon, Ehime, 791-0295, JapanDepartment of Neurology and Clinical Pharmacology, Ehime University Graduate School of Medicine, 454 Shitsukawa, Toon, Ehime, 791-0295, JapanDepartment of Neurology and Clinical Pharmacology, Ehime University Graduate School of Medicine, 454 Shitsukawa, Toon, Ehime, 791-0295, JapanTreatment with dopaminergic agents result excessive daytime sleepiness (EDS) and some studies have shown the benefit of using modafinil for treating excessive daytime sleepiness of Parkinson's disease (PD) patient. We investigated whether modafinil have ameliorative properties against levodopa induced excessive nighttime sleepiness (ENS) in MPTP-treated murine nocturnal PD model. Our EEG analyses of whole day recordings revealed that modafinil reduce ENS of this nocturnal PD models with levodopa medications. Therefore, we investigated whether, modafinil post-treatment followed by MPTP shows any effect on monoamine contents of brain and found to robustly increased noradrenaline (NA) concentration of MPTP treated mice. Modafinil post-treatment, in neurorestorative context (5 days post-lesion) led to increased striatal dopamine (DA) concentrations of MPTP-treated mice. Here, we first confirmed that modafinil ameliorates levodopa induced excessive sleepiness and restores monoaminergic systems. The arousal and anti-parkinsonian effects displayed by modafinil indicate that in combination with dopaminergic agents, modafinil co-administration may be worthwhile in trying to suppress the excessive daytime sleepiness and progressive dopaminergic neuron loss in PD. Keywords: Parkinson's disease, Excessive day time sleepiness, Monoamines, MPTP, Modafinil, Neurorestoration, Nocturnalhttp://www.sciencedirect.com/science/article/pii/S1347861318300586 |
| spellingShingle | Rina Ando Mohammed Emamussalehin Choudhury Yuki Yamanishi Win Thiri Kyaw Madoka Kubo Mariko Kannou Noriko Nishikawa Junya Tanaka Masahiro Nomoto Masahiro Nagai Modafinil alleviates levodopa-induced excessive nighttime sleepiness and restores monoaminergic systems in a nocturnal animal model of Parkinson's disease Journal of Pharmacological Sciences |
| title | Modafinil alleviates levodopa-induced excessive nighttime sleepiness and restores monoaminergic systems in a nocturnal animal model of Parkinson's disease |
| title_full | Modafinil alleviates levodopa-induced excessive nighttime sleepiness and restores monoaminergic systems in a nocturnal animal model of Parkinson's disease |
| title_fullStr | Modafinil alleviates levodopa-induced excessive nighttime sleepiness and restores monoaminergic systems in a nocturnal animal model of Parkinson's disease |
| title_full_unstemmed | Modafinil alleviates levodopa-induced excessive nighttime sleepiness and restores monoaminergic systems in a nocturnal animal model of Parkinson's disease |
| title_short | Modafinil alleviates levodopa-induced excessive nighttime sleepiness and restores monoaminergic systems in a nocturnal animal model of Parkinson's disease |
| title_sort | modafinil alleviates levodopa induced excessive nighttime sleepiness and restores monoaminergic systems in a nocturnal animal model of parkinson s disease |
| url | http://www.sciencedirect.com/science/article/pii/S1347861318300586 |
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