Outcome in a series of 1135 twin pregnancies: does the type of conception play a role?AJOG Global Reports at a Glance
BACKGROUND: The rate of twin pregnancies conceived via assisted reproductive technology has increased markedly in recent years. The elevated number of multiple pregnancies is the most serious and frequent complication of assisted reproductive technology. Twin pregnancies are associated with higher r...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-11-01
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| Series: | AJOG Global Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666577822000776 |
| _version_ | 1811177819550515200 |
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| author | Pilar Prats, MD, PhD Janire Zarragoitia, MD Maria Ángeles Rodríguez, MD, PhD Ignacio Rodriguez, Msc Francisca Martinez, MD, PhD Alberto Rodríguez-Melcon, MD Bernat Serra, MD |
| author_facet | Pilar Prats, MD, PhD Janire Zarragoitia, MD Maria Ángeles Rodríguez, MD, PhD Ignacio Rodriguez, Msc Francisca Martinez, MD, PhD Alberto Rodríguez-Melcon, MD Bernat Serra, MD |
| author_sort | Pilar Prats, MD, PhD |
| collection | DOAJ |
| description | BACKGROUND: The rate of twin pregnancies conceived via assisted reproductive technology has increased markedly in recent years. The elevated number of multiple pregnancies is the most serious and frequent complication of assisted reproductive technology. Twin pregnancies are associated with higher rates of obstetrical complications, preterm delivery, and perinatal morbidity and mortality than singleton pregnancies. OBJECTIVE: This study aimed to investigate the association between the mode of conception and obstetrical and perinatal outcomes in twin pregnancies, adjusting for parity, age, and chorionicity. STUDY DESIGN: This was a retrospective cohort study of 1135 twin pregnancies between May 2006 and April 2021. All spontaneous (n=369) and assisted reproductive technology–conceived (n=766) twin pregnancies with antenatal care and delivery in the Universitari Quiron-Dexeus Hospital, Barcelona, Spain, a tertiary obstetrical care center, were studied according to chorionicity. RESULTS: The mean maternal age was higher among assisted reproductive technology twin pregnancies than among naturally conceived ones, and there were also less parous women in the assisted reproductive technology twin group. The global survival rates in both groups of twins were practically identical, namely 744 of 766 (97.1%) assisted reproductive technology twins and 357 of 369 (96.8%) spontaneously conceived twins. Patients with dichorionic assisted reproductive technology twins had a higher incidence of gestational diabetes (relative risk, 1.69; 95% confidence interval, 1.10–2.59) and gestational hypertension or preeclampsia (relative risk, 2.75; 95% confidence interval, 1.60–4.729). Monochorionic diamniotic assisted reproductive technology twins had a higher risk for gestational diabetes (relative risk, 4.12; 95% confidence interval, 1.35–12.56). We analyzed the gestational age at delivery, onset of labor, type of delivery, rate of preterm births, weight discordance, rate of small for gestational age neonates and intrauterine growth restriction, and admission to the neonatal intensive care unit. We could not find any statistical differences between monochorionic diamniotic assisted reproductive technology twins and spontaneously conceived twins. Among dichorionic twins, those conceived by assisted reproductive technology had an earlier gestational age at delivery (36.3±2.29 vs 36.6±2; P<.05) and we found statistical differences in the onset of labor with more cesarean deliveries (relative risk, 1.27; 95% confidence interval, 1.06–1.51). When adjusting for cofounding factors (maternal age, parity, chorionicity), the type of conception remained an independent risk factor for gestational hypertension and preeclampsia but not for gestational diabetes or cesarean delivery. CONCLUSION: Pregnancy outcomes are comparable between assisted reproductive technology and spontaneously conceived twins, and when adjusted for confounding factors, only the risk for gestational hypertension and preeclampsia remained increased in the assisted reproductive technology group. |
| first_indexed | 2024-04-11T06:07:49Z |
| format | Article |
| id | doaj.art-905cd5c7ee004a11af784e500d94d570 |
| institution | Directory Open Access Journal |
| issn | 2666-5778 |
| language | English |
| last_indexed | 2024-04-11T06:07:49Z |
| publishDate | 2022-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | AJOG Global Reports |
| spelling | doaj.art-905cd5c7ee004a11af784e500d94d5702022-12-22T04:41:27ZengElsevierAJOG Global Reports2666-57782022-11-0124100129Outcome in a series of 1135 twin pregnancies: does the type of conception play a role?AJOG Global Reports at a GlancePilar Prats, MD, PhD0Janire Zarragoitia, MD1Maria Ángeles Rodríguez, MD, PhD2Ignacio Rodriguez, Msc3Francisca Martinez, MD, PhD4Alberto Rodríguez-Melcon, MD5Bernat Serra, MD6Obstetrics Service, Department of Obstetrics, Gynecology, and Reproductive Medicine, Institut Universitari Dexeus, Barcelona, Spain (Drs Prats, Zarragoitia, Rodríguez-Melcon, and Serra); Fetal Medicine Unit, Department of Obstetrics, Gynecology, and Reproductive Medicine, Institut Universitari Dexeus, Barcelona, Spain (Drs Prats and Rodríguez); Corresponding author: Pilar Prats, MD, PhD.Obstetrics Service, Department of Obstetrics, Gynecology, and Reproductive Medicine, Institut Universitari Dexeus, Barcelona, Spain (Drs Prats, Zarragoitia, Rodríguez-Melcon, and Serra)Fetal Medicine Unit, Department of Obstetrics, Gynecology, and Reproductive Medicine, Institut Universitari Dexeus, Barcelona, Spain (Drs Prats and Rodríguez)Epidemiological Unit, Department of Obstetrics, Gynecology, and Reproductive Medicine, Institut Universitari Dexeus, Barcelona, Spain (Mr Rodriguez)Reproductive Medicine Service, Department of Obstetrics, Gynecology, and Reproductive Medicine, Institut Universitari Dexeus, Barcelona, Spain (Dr Martinez).Obstetrics Service, Department of Obstetrics, Gynecology, and Reproductive Medicine, Institut Universitari Dexeus, Barcelona, Spain (Drs Prats, Zarragoitia, Rodríguez-Melcon, and Serra)Obstetrics Service, Department of Obstetrics, Gynecology, and Reproductive Medicine, Institut Universitari Dexeus, Barcelona, Spain (Drs Prats, Zarragoitia, Rodríguez-Melcon, and Serra)BACKGROUND: The rate of twin pregnancies conceived via assisted reproductive technology has increased markedly in recent years. The elevated number of multiple pregnancies is the most serious and frequent complication of assisted reproductive technology. Twin pregnancies are associated with higher rates of obstetrical complications, preterm delivery, and perinatal morbidity and mortality than singleton pregnancies. OBJECTIVE: This study aimed to investigate the association between the mode of conception and obstetrical and perinatal outcomes in twin pregnancies, adjusting for parity, age, and chorionicity. STUDY DESIGN: This was a retrospective cohort study of 1135 twin pregnancies between May 2006 and April 2021. All spontaneous (n=369) and assisted reproductive technology–conceived (n=766) twin pregnancies with antenatal care and delivery in the Universitari Quiron-Dexeus Hospital, Barcelona, Spain, a tertiary obstetrical care center, were studied according to chorionicity. RESULTS: The mean maternal age was higher among assisted reproductive technology twin pregnancies than among naturally conceived ones, and there were also less parous women in the assisted reproductive technology twin group. The global survival rates in both groups of twins were practically identical, namely 744 of 766 (97.1%) assisted reproductive technology twins and 357 of 369 (96.8%) spontaneously conceived twins. Patients with dichorionic assisted reproductive technology twins had a higher incidence of gestational diabetes (relative risk, 1.69; 95% confidence interval, 1.10–2.59) and gestational hypertension or preeclampsia (relative risk, 2.75; 95% confidence interval, 1.60–4.729). Monochorionic diamniotic assisted reproductive technology twins had a higher risk for gestational diabetes (relative risk, 4.12; 95% confidence interval, 1.35–12.56). We analyzed the gestational age at delivery, onset of labor, type of delivery, rate of preterm births, weight discordance, rate of small for gestational age neonates and intrauterine growth restriction, and admission to the neonatal intensive care unit. We could not find any statistical differences between monochorionic diamniotic assisted reproductive technology twins and spontaneously conceived twins. Among dichorionic twins, those conceived by assisted reproductive technology had an earlier gestational age at delivery (36.3±2.29 vs 36.6±2; P<.05) and we found statistical differences in the onset of labor with more cesarean deliveries (relative risk, 1.27; 95% confidence interval, 1.06–1.51). When adjusting for cofounding factors (maternal age, parity, chorionicity), the type of conception remained an independent risk factor for gestational hypertension and preeclampsia but not for gestational diabetes or cesarean delivery. CONCLUSION: Pregnancy outcomes are comparable between assisted reproductive technology and spontaneously conceived twins, and when adjusted for confounding factors, only the risk for gestational hypertension and preeclampsia remained increased in the assisted reproductive technology group.http://www.sciencedirect.com/science/article/pii/S2666577822000776assisted reproductive techniqueschorionicityobstetrical complicationsoutcomeperinatal morbiditytwins |
| spellingShingle | Pilar Prats, MD, PhD Janire Zarragoitia, MD Maria Ángeles Rodríguez, MD, PhD Ignacio Rodriguez, Msc Francisca Martinez, MD, PhD Alberto Rodríguez-Melcon, MD Bernat Serra, MD Outcome in a series of 1135 twin pregnancies: does the type of conception play a role?AJOG Global Reports at a Glance AJOG Global Reports assisted reproductive techniques chorionicity obstetrical complications outcome perinatal morbidity twins |
| title | Outcome in a series of 1135 twin pregnancies: does the type of conception play a role?AJOG Global Reports at a Glance |
| title_full | Outcome in a series of 1135 twin pregnancies: does the type of conception play a role?AJOG Global Reports at a Glance |
| title_fullStr | Outcome in a series of 1135 twin pregnancies: does the type of conception play a role?AJOG Global Reports at a Glance |
| title_full_unstemmed | Outcome in a series of 1135 twin pregnancies: does the type of conception play a role?AJOG Global Reports at a Glance |
| title_short | Outcome in a series of 1135 twin pregnancies: does the type of conception play a role?AJOG Global Reports at a Glance |
| title_sort | outcome in a series of 1135 twin pregnancies does the type of conception play a role ajog global reports at a glance |
| topic | assisted reproductive techniques chorionicity obstetrical complications outcome perinatal morbidity twins |
| url | http://www.sciencedirect.com/science/article/pii/S2666577822000776 |
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