The Relationship of Maternal KIR and Parental HLA-C Genes With Risk of Recurrent Spontaneous Abortion: A Regional Study in Lorestan Province, Iran
Objectives: Natural killer cells (NKs) are one of the most important cells which play a key role in fetomaternal immune tolerance. This immune tolerance is induced by the interaction of fetal human leucocyte antigens (HLAs) and maternal killer-cell immunoglobulin-like receptors (KIRs). Hence, we int...
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| Format: | Article |
| Language: | English |
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Aras Part Medical International Press
2018-07-01
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| Series: | Crescent Journal of Medical and Biological Sciences |
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| Online Access: | http://cjmb.org/uploads/pdf/pdf_CJMB_186.pdf |
| _version_ | 1819087657118990336 |
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| author | Soheila Akbari Seyyed Amir Yasin Ahmadi Farhad Shahsavar |
| author_facet | Soheila Akbari Seyyed Amir Yasin Ahmadi Farhad Shahsavar |
| author_sort | Soheila Akbari |
| collection | DOAJ |
| description | Objectives: Natural killer cells (NKs) are one of the most important cells which play a key role in fetomaternal immune tolerance. This immune tolerance is induced by the interaction of fetal human leucocyte antigens (HLAs) and maternal killer-cell immunoglobulin-like receptors (KIRs). Hence, we intended to investigate the relationship of maternal KIR, parental HLA-C, and maternal-parental KIR+HLA-C with the risk of recurrent spontaneous abortion (RSA).
Materials and Methods: The present regional study in Lorestan province of Iran was conducted as a case-control study on 200 couples. Polymerase chain reaction with sequence-specifc primers (PCR-SSP) was used in order to detect genes.
Results: A signifcant correlation was found for maternal KIR2DS1 in combination with paternal HLA-C2 (P=0.0089; OR=2.25). Likewise, a signifcant relation was found for maternal C1C2 in combination with paternal C1 or C2 (P=0.0289; OR=2.25). No signifcant relation was found for KIR genes alone.
Conclusions: Our study showed a signifcant relation for maternal KIR2DS1 in combination with paternal HLA-C2 as a risk factor in our region. Investigations on this combination for increasing the success rate of assisted reproduction, for frst trimester abortions occurring after implantation and early placentation, for stillbirth groups, and for successful and unsuccessful pregnancies with malformed embryos and fetuses are suggested. |
| first_indexed | 2024-12-21T21:39:37Z |
| format | Article |
| id | doaj.art-905cea4bb46b4c78899deb3fcb72b6d4 |
| institution | Directory Open Access Journal |
| issn | 2148-9696 2148-9696 |
| language | English |
| last_indexed | 2024-12-21T21:39:37Z |
| publishDate | 2018-07-01 |
| publisher | Aras Part Medical International Press |
| record_format | Article |
| series | Crescent Journal of Medical and Biological Sciences |
| spelling | doaj.art-905cea4bb46b4c78899deb3fcb72b6d42022-12-21T18:49:24ZengAras Part Medical International PressCrescent Journal of Medical and Biological Sciences2148-96962148-96962018-07-0153194197The Relationship of Maternal KIR and Parental HLA-C Genes With Risk of Recurrent Spontaneous Abortion: A Regional Study in Lorestan Province, IranSoheila Akbari0Seyyed Amir Yasin Ahmadi1 Farhad Shahsavar2Department of Obstetrics and Gynecology, Lorestan University of Medical Sciences, Khorramabad, IranPediatric Growth and Development Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, IranDepartment of Immunology, Lorestan University of Medical Sciences, Khorramabad, IranDepartment of Immunology, Lorestan University of Medical Sciences, Khorramabad, IranObjectives: Natural killer cells (NKs) are one of the most important cells which play a key role in fetomaternal immune tolerance. This immune tolerance is induced by the interaction of fetal human leucocyte antigens (HLAs) and maternal killer-cell immunoglobulin-like receptors (KIRs). Hence, we intended to investigate the relationship of maternal KIR, parental HLA-C, and maternal-parental KIR+HLA-C with the risk of recurrent spontaneous abortion (RSA). Materials and Methods: The present regional study in Lorestan province of Iran was conducted as a case-control study on 200 couples. Polymerase chain reaction with sequence-specifc primers (PCR-SSP) was used in order to detect genes. Results: A signifcant correlation was found for maternal KIR2DS1 in combination with paternal HLA-C2 (P=0.0089; OR=2.25). Likewise, a signifcant relation was found for maternal C1C2 in combination with paternal C1 or C2 (P=0.0289; OR=2.25). No signifcant relation was found for KIR genes alone. Conclusions: Our study showed a signifcant relation for maternal KIR2DS1 in combination with paternal HLA-C2 as a risk factor in our region. Investigations on this combination for increasing the success rate of assisted reproduction, for frst trimester abortions occurring after implantation and early placentation, for stillbirth groups, and for successful and unsuccessful pregnancies with malformed embryos and fetuses are suggested.http://cjmb.org/uploads/pdf/pdf_CJMB_186.pdfRecurrent spontaneous abortionKIRHLA-C |
| spellingShingle | Soheila Akbari Seyyed Amir Yasin Ahmadi Farhad Shahsavar The Relationship of Maternal KIR and Parental HLA-C Genes With Risk of Recurrent Spontaneous Abortion: A Regional Study in Lorestan Province, Iran Crescent Journal of Medical and Biological Sciences Recurrent spontaneous abortion KIR HLA-C |
| title | The Relationship of Maternal KIR and Parental HLA-C Genes With Risk of Recurrent Spontaneous Abortion: A Regional Study in Lorestan Province, Iran |
| title_full | The Relationship of Maternal KIR and Parental HLA-C Genes With Risk of Recurrent Spontaneous Abortion: A Regional Study in Lorestan Province, Iran |
| title_fullStr | The Relationship of Maternal KIR and Parental HLA-C Genes With Risk of Recurrent Spontaneous Abortion: A Regional Study in Lorestan Province, Iran |
| title_full_unstemmed | The Relationship of Maternal KIR and Parental HLA-C Genes With Risk of Recurrent Spontaneous Abortion: A Regional Study in Lorestan Province, Iran |
| title_short | The Relationship of Maternal KIR and Parental HLA-C Genes With Risk of Recurrent Spontaneous Abortion: A Regional Study in Lorestan Province, Iran |
| title_sort | relationship of maternal kir and parental hla c genes with risk of recurrent spontaneous abortion a regional study in lorestan province iran |
| topic | Recurrent spontaneous abortion KIR HLA-C |
| url | http://cjmb.org/uploads/pdf/pdf_CJMB_186.pdf |
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