Induction of Proteasome Subunit Low Molecular Weight Protein (LMP)-2 Is Required to Induce Active Remodeling in Adult Rat Ventricular Cardiomyocytes

Induction of Proteasome Subunit Low Molecular Weight Protein (LMP)-2 Is Required to Induce Active Remodeling in Adult Rat Ventricular Cardiomyocytes

Isolated adult rat ventricular cardiomyocytes (ARVC) adapt to the two-dimensional surface of culture dishes once they are isolated from the three-dimensional heart tissue. This process mimics aspects of cardiac adaptation to pressure overload and requires an initial breakdown of sarcomeric structure...

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Bibliographic Details
Main Authors: Antonia Petersen, Hanna Sarah Kutsche, Franziska Nippert, Rolf Schreckenberg, Rainer Schulz, Klaus-Dieter Schlüter
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Medical Sciences
Subjects:
cardiac remodeling
cardiac hypertrophy
proteasome
Online Access:https://www.mdpi.com/2076-3271/8/2/21

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