Prenatal Exposure to Persistent Organic Pollutants and Maternal Folic Acid Supplementation: Their Impact on Glucose Homeostasis in Male Rat Descendants
Exposure to persistent organic pollutants (POPs) is associated with insulin resistance while folic acid (FA) may offer a protective effect. However, the paternal contribution to metabolic phenotypes in offspring is not well known yet. Hence, we investigated whether maternal exposure to POPs affects...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-03-01
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| Series: | Environments |
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| Online Access: | https://www.mdpi.com/2076-3298/8/3/24 |
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| author | Pauline Navarro Mathieu Dalvai Phanie L. Charest Pauline M. Herst Maryse Lessard Bruno Marcotte Nadine Leblanc Sarah Kimmins Jacquetta Trasler Amanda J. MacFarlane André Marette Janice L. Bailey Hélène Jacques |
| author_facet | Pauline Navarro Mathieu Dalvai Phanie L. Charest Pauline M. Herst Maryse Lessard Bruno Marcotte Nadine Leblanc Sarah Kimmins Jacquetta Trasler Amanda J. MacFarlane André Marette Janice L. Bailey Hélène Jacques |
| author_sort | Pauline Navarro |
| collection | DOAJ |
| description | Exposure to persistent organic pollutants (POPs) is associated with insulin resistance while folic acid (FA) may offer a protective effect. However, the paternal contribution to metabolic phenotypes in offspring is not well known yet. Hence, we investigated whether maternal exposure to POPs affects glucose homeostasis and whether maternal FA supplementation counteracts POP effects transmitted via male descendants. Sprague–Dawley founder dams (F0) were fed a diet containing 2 or 6 mg/kg of FA and were force-fed with either a POP mixture or corn oil for 9 weeks. Subsequent male descendants did not receive any treatment. Blood glucose, plasma insulin and C-peptide were measured during an oral glucose tolerance test in males aged 90 and 180 days from generation 1 (F1), 2 (F2) and 3 (F3). Prenatal POP exposure increased fasting glucose in 90-day-old F1 males and C-peptide in 90-day-old F2 males. Prenatal FA supplementation decreased C-peptide in 90 and 180-day-old F1 males. In 180-day-old F3 males, FA supplementation counteracted POPs on fasting and postglucose C-peptide, indicating reduced insulin secretion. Prenatal exposure to an environmentally relevant POP mixture caused abnormalities in glucose homeostasis that are transmitted from one generation to the next through the paternal lineage. Prenatal FA supplementation counteracted some of the deleterious effects of POPs on glucose homeostasis. |
| first_indexed | 2024-03-10T13:01:07Z |
| format | Article |
| id | doaj.art-905d99a06c7b4e5885ef9b65b7b34f6c |
| institution | Directory Open Access Journal |
| issn | 2076-3298 |
| language | English |
| last_indexed | 2024-03-10T13:01:07Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Environments |
| spelling | doaj.art-905d99a06c7b4e5885ef9b65b7b34f6c2023-11-21T11:29:07ZengMDPI AGEnvironments2076-32982021-03-01832410.3390/environments8030024Prenatal Exposure to Persistent Organic Pollutants and Maternal Folic Acid Supplementation: Their Impact on Glucose Homeostasis in Male Rat DescendantsPauline Navarro0Mathieu Dalvai1Phanie L. Charest2Pauline M. Herst3Maryse Lessard4Bruno Marcotte5Nadine Leblanc6Sarah Kimmins7Jacquetta Trasler8Amanda J. MacFarlane9André Marette10Janice L. Bailey11Hélène Jacques12School of Nutrition, Faculty of Agricultural and Food Sciences, Université Laval, 2425 rue de l’Agriculture, Quebec City, QC G1V 0A6, CanadaCentre de Recherche en Reproduction, Développement et Santé Intergénérationnelle, Université Laval, 2425 rue de l’Agriculture, Quebec City, QC G1V 0A6, CanadaCentre de Recherche en Reproduction, Développement et Santé Intergénérationnelle, Université Laval, 2425 rue de l’Agriculture, Quebec City, QC G1V 0A6, CanadaCentre de Recherche en Reproduction, Développement et Santé Intergénérationnelle, Université Laval, 2425 rue de l’Agriculture, Quebec City, QC G1V 0A6, CanadaCentre de Recherche en Reproduction, Développement et Santé Intergénérationnelle, Université Laval, 2425 rue de l’Agriculture, Quebec City, QC G1V 0A6, CanadaInstitute of Nutrition and Functional Foods, Université Laval, 2440 Boulevard Hochelaga, Quebec City, QC G1V 0A6, CanadaSchool of Nutrition, Faculty of Agricultural and Food Sciences, Université Laval, 2425 rue de l’Agriculture, Quebec City, QC G1V 0A6, CanadaDepartment of Pharmacology and Therapeutics, Faculty of Medicine, McGill University, 3655 Promenade Sir William Osler Room 1325, Montreal, QC H3G 1Y6, CanadaDepartment of Pediatrics, Montreal Children’s Hospital, McGill University Health Centre Research Institute, McGill University, 1001 Boulevard Décarie, Montreal, QC H4A 3J1, CanadaNutrition Research Division, Health Canada, 251 Promenade Sir Frederick Banting, Ottawa, ON K1A 0K9, CanadaInstitute of Nutrition and Functional Foods, Université Laval, 2440 Boulevard Hochelaga, Quebec City, QC G1V 0A6, CanadaCentre de Recherche en Reproduction, Développement et Santé Intergénérationnelle, Université Laval, 2425 rue de l’Agriculture, Quebec City, QC G1V 0A6, CanadaSchool of Nutrition, Faculty of Agricultural and Food Sciences, Université Laval, 2425 rue de l’Agriculture, Quebec City, QC G1V 0A6, CanadaExposure to persistent organic pollutants (POPs) is associated with insulin resistance while folic acid (FA) may offer a protective effect. However, the paternal contribution to metabolic phenotypes in offspring is not well known yet. Hence, we investigated whether maternal exposure to POPs affects glucose homeostasis and whether maternal FA supplementation counteracts POP effects transmitted via male descendants. Sprague–Dawley founder dams (F0) were fed a diet containing 2 or 6 mg/kg of FA and were force-fed with either a POP mixture or corn oil for 9 weeks. Subsequent male descendants did not receive any treatment. Blood glucose, plasma insulin and C-peptide were measured during an oral glucose tolerance test in males aged 90 and 180 days from generation 1 (F1), 2 (F2) and 3 (F3). Prenatal POP exposure increased fasting glucose in 90-day-old F1 males and C-peptide in 90-day-old F2 males. Prenatal FA supplementation decreased C-peptide in 90 and 180-day-old F1 males. In 180-day-old F3 males, FA supplementation counteracted POPs on fasting and postglucose C-peptide, indicating reduced insulin secretion. Prenatal exposure to an environmentally relevant POP mixture caused abnormalities in glucose homeostasis that are transmitted from one generation to the next through the paternal lineage. Prenatal FA supplementation counteracted some of the deleterious effects of POPs on glucose homeostasis.https://www.mdpi.com/2076-3298/8/3/24pollutantsfolic acidmetabolic defectsinsulin resistanceprenatal exposuremale lineage |
| spellingShingle | Pauline Navarro Mathieu Dalvai Phanie L. Charest Pauline M. Herst Maryse Lessard Bruno Marcotte Nadine Leblanc Sarah Kimmins Jacquetta Trasler Amanda J. MacFarlane André Marette Janice L. Bailey Hélène Jacques Prenatal Exposure to Persistent Organic Pollutants and Maternal Folic Acid Supplementation: Their Impact on Glucose Homeostasis in Male Rat Descendants Environments pollutants folic acid metabolic defects insulin resistance prenatal exposure male lineage |
| title | Prenatal Exposure to Persistent Organic Pollutants and Maternal Folic Acid Supplementation: Their Impact on Glucose Homeostasis in Male Rat Descendants |
| title_full | Prenatal Exposure to Persistent Organic Pollutants and Maternal Folic Acid Supplementation: Their Impact on Glucose Homeostasis in Male Rat Descendants |
| title_fullStr | Prenatal Exposure to Persistent Organic Pollutants and Maternal Folic Acid Supplementation: Their Impact on Glucose Homeostasis in Male Rat Descendants |
| title_full_unstemmed | Prenatal Exposure to Persistent Organic Pollutants and Maternal Folic Acid Supplementation: Their Impact on Glucose Homeostasis in Male Rat Descendants |
| title_short | Prenatal Exposure to Persistent Organic Pollutants and Maternal Folic Acid Supplementation: Their Impact on Glucose Homeostasis in Male Rat Descendants |
| title_sort | prenatal exposure to persistent organic pollutants and maternal folic acid supplementation their impact on glucose homeostasis in male rat descendants |
| topic | pollutants folic acid metabolic defects insulin resistance prenatal exposure male lineage |
| url | https://www.mdpi.com/2076-3298/8/3/24 |
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