Comparison of Intravenous Ranitidine with Pantoprazole in Decreasing Gastric Fluid Acidity in Emergency Cesarean Section
Objectives: Peri-operative aspiration of gastric contents is a problem that causes certain respiratory problems including ARDS. Prophylaxis against aspiration of gastric contents is performed routinely in elective surgeries, but there is rare evidence on the efficacy of this method in emergency cesa...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2013-10-01
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| Series: | Patient Safety and Quality Improvement Journal |
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| Online Access: | http://psj.mums.ac.ir/pdf_1789_d25e38266e0a82c64f1db53cbbf5dc92.html |
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| author | Alipour M Soltani Gh Zirak N ParaviTorghabeh N Peivandi Yazdi A |
| author_facet | Alipour M Soltani Gh Zirak N ParaviTorghabeh N Peivandi Yazdi A |
| author_sort | Alipour M |
| collection | DOAJ |
| description | Objectives: Peri-operative aspiration of gastric contents is a problem that causes certain respiratory problems including ARDS. Prophylaxis against aspiration of gastric contents is performed routinely in elective surgeries, but there is rare evidence on the efficacy of this method in emergency cesarean section. Materials and Methods: This is a randomized, controlled, double-blinded clinical trial. 60 parturients undergoing emergency cesarean section were randomly assigned into three groups of 20 each. They were allocated into two study and one placebo groups. The study group one and two received intravenous ranitidine (IV) 50 mg or IV pantoprazole 40 mg, half an hour before induction of GA, respectively. The placebo group was administered just 5 ml of isotonic saline half an hour before GA induction. After intubation and confirmation of endotracheal tube insertion, the gastric contents were aspirated through a nasogastric tube for evaluation of acidity and volume. Results: A statistical difference between group one and two with the control group was observed in the acidity of gastric contents, but there was no difference in volume. Also, the PH level of gastric contents in patients receiving pantoprazole was significantly higher than the isotonic saline (p |
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| format | Article |
| id | doaj.art-9060898b53d34c7e9c0952abf1d16462 |
| institution | Directory Open Access Journal |
| issn | 2345-4482 2345-4490 |
| language | English |
| last_indexed | 2024-04-14T01:24:34Z |
| publishDate | 2013-10-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Patient Safety and Quality Improvement Journal |
| spelling | doaj.art-9060898b53d34c7e9c0952abf1d164622022-12-22T02:20:31ZengMashhad University of Medical SciencesPatient Safety and Quality Improvement Journal2345-44822345-44902013-10-0111141789Comparison of Intravenous Ranitidine with Pantoprazole in Decreasing Gastric Fluid Acidity in Emergency Cesarean SectionAlipour M0Soltani Gh1Zirak N2ParaviTorghabeh N3Peivandi Yazdi A4Assistant professor of Anesthesiology, Cardiac Anesthesia Research Center, Faculty of medicine, Mashhad University of Medical Sciences ,Mashhad, IranAssociated professor of Anesthesiology, Cardiac Anesthesia Research Center, Faculty of medicine, Mashhad University of Medical Sciences, Mashhad, IranAssociated professor of Anesthesiology, Cardiac Anesthesia Research Center, Faculty of medicine, Mashhad University of Medical Sciences, Mashhad, IranAssistant of Anesthesiology, Cardiac Anesthesia Research Center, Faculty of medicine, Mashhad University of Medical Sciences, Mashhad, IranAssistant professor of Anesthesiology, Research Center for Patient Safety, Mashhad University of Medical Sciences, Mashhad, IranObjectives: Peri-operative aspiration of gastric contents is a problem that causes certain respiratory problems including ARDS. Prophylaxis against aspiration of gastric contents is performed routinely in elective surgeries, but there is rare evidence on the efficacy of this method in emergency cesarean section. Materials and Methods: This is a randomized, controlled, double-blinded clinical trial. 60 parturients undergoing emergency cesarean section were randomly assigned into three groups of 20 each. They were allocated into two study and one placebo groups. The study group one and two received intravenous ranitidine (IV) 50 mg or IV pantoprazole 40 mg, half an hour before induction of GA, respectively. The placebo group was administered just 5 ml of isotonic saline half an hour before GA induction. After intubation and confirmation of endotracheal tube insertion, the gastric contents were aspirated through a nasogastric tube for evaluation of acidity and volume. Results: A statistical difference between group one and two with the control group was observed in the acidity of gastric contents, but there was no difference in volume. Also, the PH level of gastric contents in patients receiving pantoprazole was significantly higher than the isotonic saline (phttp://psj.mums.ac.ir/pdf_1789_d25e38266e0a82c64f1db53cbbf5dc92.htmlCaesarian sectionPantoprazolePulmonary aspirationRanitidine |
| spellingShingle | Alipour M Soltani Gh Zirak N ParaviTorghabeh N Peivandi Yazdi A Comparison of Intravenous Ranitidine with Pantoprazole in Decreasing Gastric Fluid Acidity in Emergency Cesarean Section Patient Safety and Quality Improvement Journal Caesarian section Pantoprazole Pulmonary aspiration Ranitidine |
| title | Comparison of Intravenous Ranitidine with Pantoprazole in Decreasing Gastric Fluid Acidity in Emergency Cesarean Section |
| title_full | Comparison of Intravenous Ranitidine with Pantoprazole in Decreasing Gastric Fluid Acidity in Emergency Cesarean Section |
| title_fullStr | Comparison of Intravenous Ranitidine with Pantoprazole in Decreasing Gastric Fluid Acidity in Emergency Cesarean Section |
| title_full_unstemmed | Comparison of Intravenous Ranitidine with Pantoprazole in Decreasing Gastric Fluid Acidity in Emergency Cesarean Section |
| title_short | Comparison of Intravenous Ranitidine with Pantoprazole in Decreasing Gastric Fluid Acidity in Emergency Cesarean Section |
| title_sort | comparison of intravenous ranitidine with pantoprazole in decreasing gastric fluid acidity in emergency cesarean section |
| topic | Caesarian section Pantoprazole Pulmonary aspiration Ranitidine |
| url | http://psj.mums.ac.ir/pdf_1789_d25e38266e0a82c64f1db53cbbf5dc92.html |
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